全文获取类型
收费全文 | 1274篇 |
免费 | 52篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 87篇 |
妇产科学 | 23篇 |
基础医学 | 140篇 |
口腔科学 | 18篇 |
临床医学 | 150篇 |
内科学 | 384篇 |
皮肤病学 | 9篇 |
神经病学 | 39篇 |
特种医学 | 19篇 |
外科学 | 146篇 |
综合类 | 4篇 |
预防医学 | 158篇 |
眼科学 | 7篇 |
药学 | 90篇 |
肿瘤学 | 48篇 |
出版年
2022年 | 13篇 |
2021年 | 43篇 |
2020年 | 10篇 |
2019年 | 22篇 |
2018年 | 31篇 |
2017年 | 21篇 |
2016年 | 21篇 |
2015年 | 19篇 |
2014年 | 28篇 |
2013年 | 44篇 |
2012年 | 55篇 |
2011年 | 44篇 |
2010年 | 35篇 |
2009年 | 18篇 |
2008年 | 36篇 |
2007年 | 55篇 |
2006年 | 46篇 |
2005年 | 54篇 |
2004年 | 55篇 |
2003年 | 53篇 |
2002年 | 49篇 |
2001年 | 39篇 |
2000年 | 49篇 |
1999年 | 33篇 |
1998年 | 6篇 |
1995年 | 8篇 |
1994年 | 6篇 |
1993年 | 6篇 |
1992年 | 23篇 |
1991年 | 30篇 |
1990年 | 31篇 |
1989年 | 34篇 |
1988年 | 29篇 |
1987年 | 19篇 |
1986年 | 24篇 |
1985年 | 23篇 |
1984年 | 22篇 |
1983年 | 19篇 |
1982年 | 14篇 |
1981年 | 8篇 |
1980年 | 14篇 |
1979年 | 25篇 |
1978年 | 9篇 |
1977年 | 7篇 |
1976年 | 10篇 |
1975年 | 10篇 |
1973年 | 11篇 |
1972年 | 20篇 |
1971年 | 6篇 |
1969年 | 9篇 |
排序方式: 共有1330条查询结果,搜索用时 31 毫秒
991.
992.
993.
Male pseudohermaphroditism: long-term quality of life outcome in five 46,XY individuals reared female 总被引:1,自引:0,他引:1
Mazur T Sandberg DE Perrin MA Gallagher JA MacGilliivray MH 《Journal of pediatric endocrinology & metabolism : JPEM》2004,17(6):809-823
We assessed the adult quality of life of five medical chart-selected genetic males (ages 29-34 years) assigned and reared as females due to ambiguity of the external genitalia. All five were treated following the traditional method proposed by John Money and colleagues in 1955, commonly referred to as the "optimal gender policy". The adult follow-up assessment included physical and endocrinological evaluation, completion of self-report questionnaires, and a semi-structured interview assessing gender identity, sexual experience and orientation. Quality of life domains assessed by questionnaire included health-related issues, satisfaction with health-care management, emotional distress, and relationship satisfaction. Vaginoplasty in four out of five patients was initially unsuccessful. Four patients had periodic lapses in adherence to hormone replacement therapy. Gender role behavior across development was masculine relative to norms for women. All participants reported a female gender identity without a history of gender dysphoria. The majority of participants (four of five) reported being sexually active and in long-term relationships (three heterosexual, one homosexual). Current emotional adaptation and health-related quality of life are within the normal range for four participants. Sex assignment of 46,XY individuals with ambiguous genitalia as females is compatible with a positive quality of life. 相似文献
994.
Heresi GP Mancias P Mazur LJ Butler IJ Murphy JR Cleary TG 《The Pediatric infectious disease journal》2004,23(8):788-789
West Nile virus (WNV) infections of the central nervous system are very uncommon in U.S. children. We report a child with a poliomyelitis-like presentation in which WNV was the only detected pathogen. WNV has not previously been associated with a poliomyelitis-like presentation in children. 相似文献
995.
Todurov BM Zakharova VP Onishchenko VF Mazur AP Kovtun HI Kuz'mych IM 《Klinichna khirurhiia / Ministerstvo okhorony zdorov'ia Ukra?ny, Naukove tovarystvo khirurhiv Ukra?ny》2005,(7):38-41
Basing on results of pathologoanatomical investigations, performed in 26 cases, the lungs changes in pulmonary thromboembolism were analyzed. It was shown, that an acute thromboembolism of a. pulmonalis main branches did not cause an acute necrosis of pulmonary alveolar tissue, but induces progressive diffuse changes of their microcircular bed, concomitant with pulmonary hypertension. In cases of chronical pulmonary thromboembolism the diffuse vascular sclerosis of the nonaffected lung and the alveolar tissue emphysema are formed, and in such cases the signs of pulmonary hypertension showing hypertrophy of the muscular vessels middle layer as well as their intima hyperplasia are revealed. This determines the expediency of earlier start of thrombolytic therapy conduction as well as surgical intervention in an acute pulmonary thromboembolism. 相似文献
996.
Heilman RL Mazur MJ Reddy KS Moss A Post D Mulligan D 《Transplantation proceedings》2005,37(4):1785-1788
Recent clinical trials have documented the short-term safety of steroid avoidance (SA) in kidney transplant recipients. Since July 2003, we have used a SA immunosuppression protocol for low-risk kidney transplant recipients. Eligibility criteria are age > or = 18, primary transplant (living or deceased donor), and tacrolimus started by postoperative day 3. Recipients were excluded if peak/current PRA was >50%/20%, or if they had a positive flow crossmatch, or if they had the recent use of corticosteroids (<6 months). All recipients received induction with rabbit anti-thymocyte globulin, total dose 6 mg/kg, or basiliximab. Recipients received 5 daily doses of corticosteroid and mycophenolate mofetil 1 gm twice daily starting on the day of transplantation. Tacrolimus was started when the serum creatinine level decreased by 20%, or by postoperative day 3. The goal for trough tacrolimus levels was 10-15 ng/mL for the first month, 8-12 ng/mL for months 2-3, and 5-10 ng/mL after month 3. Protocol biopsies (bx) were performed at reperfusion, 1 month, 4 months, and 12 months. Ninety-four kidney transplantations were performed during the study period. Sixty-seven recipients (71%) were eligible and enrolled in SA. Characteristics of the 67 SA recipients: mean age, 53 years (range, 26-70); 41% female; 67% Caucasian; 24% Hispanic; 15% African American; and 5% Native American. Also, 77% received a living donor kidney. The mean follow-up was 180 days (range, 10-360). At last follow-up, 91% remained steroid-free. Biopsy-proven acute rejection (BPAR) occurred in 5 recipients (7.5%). Three recipients (4.5%) had clinical BPAR and 2 had subclinical. One recipient died with pneumonia 4 months following transplantation. Posttransplantation diabetes mellitus (PTDM) occurred in 2 (5%) of 38 recipients. In the initial 41 recipients, 27 had protocol bx at 1 month and 13 at 4 months available for analysis. Chronic allograft nephropathy (CAN) was present on protocol bx in 48% at 1 month and 69% at 4 month. Actuarial (Kaplan-Meier method) patient and graft survival rates at 351 days were 97.8% and 96.8%, respectively. SA with anti-thymocyte globulin induction in low-immunologic risk kidney transplant recipients is safe and is associated with a low risk of BPAR. The incidence of PTDM appears to be lower. 相似文献
997.
998.
999.
Stress echocardiography (SE) is currently a widely accepted method for the diagnostic and prognostic assessment of coronary
artery disease. This article reviews new concepts in SE, such as new stress techniques, new methods of endocardial border
detection, strain, tissue Doppler velocities, and others. Although some of these techniques are in their infancy, we believe
that they will become widely accepted. 相似文献
1000.
G. T. Berry T. Fukao G. A. Mitchell A. Mazur M. Ciafre J. Gibson N. Kondo M. J. Palmieri 《Journal of inherited metabolic disease》2001,24(5):587-595
Succinyl-CoA:3-oxoacid CoA-transferase (SCOT) deficiency is an inborn error of ketone body utilization, characterized by intermittent ketoacidotic crises and persistent ketosis. The diagnosis was suspected in a patient who presented with hypoglycaemia, ketoacidosis and coma at 4 days of age. The hypoglycaemic tendency was only observed during the first month of life. A novel macromolecular labelling assay in cultured skin fibroblasts using D-3-hydroxy[3-14C]butyrate supported the diagnosis. Subsequently, 9% residual SCOT activity and undetectable cross-reactive protein were noted in fibroblasts and the patient was found to be homozygous for the G324E SCOT gene mutation. By 7 years of age, recurrent episodes of ketoacidosis superimposed on persistent hyperketonaemia had resulted in over 25 hospitalizations requiring intravenous fluid, glucose and sodium bicarbonate therapy. He has had normal growth but developmental delay and attention deficit–hyperactivity disorder. A continuous intravenous glucose infusion at 38 mol (6.8 mg)/kg per min reduced plasma total ketone levels from greater than 1.5 mmol/L to less than 0.5 mmol/L after 48 h. This indicates that patients with SCOT deficiency do not always manifest ketosis with administration of a sufficient amount of carbohydrates, but that even under such conditions hyperketonaemia is difficult to eliminate completely. The presence of hypoglycaemia does not exclude the diagnosis of SCOT deficiency in infancy. 相似文献