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101.
David B. Reuben MD Thomas M. Gill MD Alan Stevens PhD Jeff Williamson MD Elena Volpi MD PhD Maya Lichtenstein MD Lee A. Jennings MD MSHS Zaldy Tan MD Leslie Evertson DNP RN GNP-BC David Bass PhD Lisa Weitzman MSSA LISW-S ASW-G C-ASWCM Martie Carnie Nancy Wilson MA MSW Katy Araujo MPH Peter Charpentier MPH Can Meng MS MPH Erich J. Greene PhD James Dziura PhD Jodi Liu PhD MSPH MSE BSE Erin Unger Mia Yang MD Katherine Currie BSPH MAT Kristin M. Lenoir MPH Aval-NaʼRee S. Green MD Sitara Abraham MPH Ashley Vernon MPH Rafael Samper-Ternent MD PhD Mukaila Raji MD MSc Roxana M. Hirst MS Rebecca Galloway PT PhD Glen R. Finney MD Ilene Ladd MS Alanna Kulchak Rahm PhD MS CGC Pamela Borek MSN RN-C Peter Peduzzi PhD 《Journal of the American Geriatrics Society》2020,68(11):2492-2499
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Norman Jones Maya Twardzicki John Ryan Theresa Jackson Mohammed Fertout Claire Henderson Neil Greenberg 《Social psychiatry and psychiatric epidemiology》2014,49(10):1667-1676
Purpose
Beliefs about other people’s potential views or reactions may be powerful determinants of mental health help-seeking behaviours. United Kingdom Armed Forces (UK AF) have made considerable efforts to promote appropriate help seeking though it is often suggested that military personnel remain reluctant to seek help. This study evaluated a novel stigma-reduction method, stand-up comedy, in service personnel.Method
Personnel viewed a regular comedy show or a show containing mental health information. Pre, immediately post-show and 3 months later, military stigmatisation, potential discrimination, mental health knowledge, help-seeking and coping behaviour, talking about mental health, current mental health and alcohol use were measured.Results
Response rates were 81.3 % pre-show, 67.6 % post-show and 18.9 % at follow-up. Inclusion of mental health material did not appear to detract from show satisfaction. Post-show, intervention group (IG) participants reported significantly less stigmatisation and accurately answered mental health-related questions; in the small numbers followed up, neither difference was maintained, however, IG personnel were statistically significantly more likely to discuss mental health and to advise others about mental health; adjusted analyses suggested that this was related to factors other than the show.Conclusion
In UK AF personnel, embedding mental health awareness within a comedy show format had a short-term positive effect upon military stigmatisation regarding mental health. The low rate of follow-up limited our ability to assess whether this effect was durable. If the longevity of change can be adequately assessed and demonstrated in further research, comedy could potentially form a component of a comprehensive stigma-reduction strategy. 相似文献106.
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Objective
Nasal obstruction during growth changes craniofacial morphology and function. However, the etiological mechanisms of these changes are unknown. The aim of the present study was to investigate the effects of nasal obstruction during growth on the maturation of the jaw-opening reflex (JOR) using an electrophysiological technique. We focused on the oral sensory receptors that regulate the activities and reflexes of the orofacial muscles.Design
Sixty 6-day-old male Wistar rats were randomly divided into control and experimental groups (n = 30 each). The experimental group underwent unilateral nasal obstruction at 8 days of age. The JOR was evoked by bilateral, low-intensity electrical stimulation of the inferior alveolar nerve. The electromyographic responses were recorded bilaterally from the digastric muscles at 5, 7, and 9 weeks of age.Results
The latency of the JOR was significantly longer and the peak-to-peak amplitude was significantly smaller in the experimental group than in the control group at each age, while the duration was not significantly different. Intragroup comparison of the latency, peak-to-peak amplitude, and duration at 5, 7, and 9 weeks of age revealed no significant differences in either the control or experimental groups.Conclusions
Unilateral nasal obstruction during growth may have significant effects on maturation of craniofacial function. 相似文献108.
Gemma Rojo Christian Castillo Juan Duaso Ana Liempi Daniel Droguett Norbel Galanti Juan Diego Maya Rodrigo López-Muñoz Ulrike Kemmerling 《Acta tropica》2014
Nifurtimox (Nfx) and Benznidazole (Bnz) are the only available drugs in use for the treatment of Chagas disease. These drugs are recommended but not fully validated in evidence-based medicine and reports about the differential toxicity of both drugs are controversial. Here, we evaluated the toxic and therapeutic effects of Nfx and Bnz on human placental chorionic villi explants (HPCVE) during ex vivo infection of Trypanosoma cruzi, performing histopathological, histochemical, immunohistochemical as well as immunofluorescence analysis of the tissue. Additionally, we determined the effect of both drugs on parasite load by real time PCR. Bnz prevents the parasite induced tissue damage in ex vivo infected HPCVE compared to Nfx, which is toxic per se. The presence of T. cruzi antigens and DNA in infected explants suggests that these drugs do not impair parasite invasion into the HPCVE. Additionally, our results confirm reports suggesting that Bnz is less toxic than Nfx and support the need for the development of more effective and better-tolerated drugs. 相似文献
109.
Santiago Nava Amalia M. Barbieri Leticia Maya Rodney Colina Atilio J. Mangold Marcelo B. Labruna José M. Venzal 《Acta tropica》2014
The aim of this work was to describe for the first time the presence of Borrelia burgdorferi sensu lato infecting ticks in Argentina. Unfed specimens of Ixodes pararicinus collected from vegetation in Jujuy Province were tested for Borrelia infection by PCR targeting the gene flagellin (fla), the rrfA-rrlB intergenic spacer region (IGS) and the 16S rDNA (rrs) gene. One male and one female of I. pararicinus collected in Jujuy were found to be positive to Borrelia infection with the three molecular markers tested. Phylogenetically, the Borrelia found in I. pararicinus from Jujuy belongs to the B. burgdorferi s.l complex, and it was similar to one of the genospecies detected in I. aragaoi from Uruguay. Also, this genospecies is closely related to two genospecies known from USA, Borrelia americana and the Borrelia sp. genospecies 1. The epidemiological risk that implies the infection with Borrelia in I. paracinus ticks from Argentina appears to be low because the genospecies detected is not suspected of having clinical relevance and there are no records of Ixodes ticks biting humans in the southern cone of South America. Further studies are needed to assess accurately if there is risk of borreliosis transmitted by ticks in South America. 相似文献
110.
Caterina Favaretti Alain Vandormael Violetta Hachaturyan Merlin Greuel Jennifer Gates Till Brnighausen Maya Adam 《JMIR Public Health and Surveillance》2022,8(1)
BackgroundShort, animated story-based (SAS) videos are a novel and promising strategy for promoting health behaviors. To gain traction as an effective health communication tool, SAS videos must demonstrate their potential to engage a diverse and global audience. In this study, we evaluate engagement with a SAS video about the consumption of added sugars, which is narrated by a child (a nonthreatening character), a mother (a neutral layperson), or a physician (a medical expert).ObjectiveThis study aims to (1) assess whether engagement with the sugar intervention video differs by narrator type (child, mother, physician) and trait proneness to reactance and (2) assess whether the demographic characteristics of the participants (age, gender, education status) are associated with different engagement profiles with the sugar intervention video.MethodsIn December 2020, after 4013 participants from the United Kingdom completed our randomized controlled trial, we offered participants assigned to the placebo arms (n=1591, 39.65%) the choice to watch the sugar intervention video (without additional compensation) as posttrial access to treatment. We measured engagement as the time that participants chose to watch the 3.42-minute video and collected data on age, gender, education status, and trait reactance proneness. Using ordinary least squares regression, we quantified the association of the demographic characteristics and trait reactance proneness with the sugar video view time.ResultsOverall, 66.43% (n=1047) of the 1576 participants in the 2 placebo arms voluntarily watched the sugar intervention video. The mean view time was 116.35 (52.4%) of 222 seconds. Results show that view times did not differ by narrator (child, mother, physician) and that older participants (aged 25-59 years, mean = 125.2 seconds) watched the sugar video longer than younger adults (aged 18-25 years, mean = 83.4 seconds). View time remained consistent across education levels. Participants with low trait reactance (mean = 119.3 seconds) watched the intervention video longer than high-trait-reactance participants (mean = 95.3 seconds), although this association did not differ by narrator type.ConclusionsThe majority of participants in our study voluntarily watched more than half of the sugar intervention video, which is a promising finding. Our results suggest that SAS videos may need to be shorter than 2 minutes to engage people who are young or have high trait proneness to reactance. We also found that the choice of narrator (child, mother, or physician) for our video did not significantly affect participant engagement. Future videos, aimed at reaching diverse audiences, could be customized for different age groups, where appropriate.Trial RegistrationGerman Clinical Trials Register DRKS00022340; https://www.drks.de/drks_web/navigate.do?navigationId=trial.HTML&TRIAL_ID=DRKS00022340International Registered Report Identifier (IRRID)RR2-10.2196/25343 相似文献