全文获取类型
收费全文 | 1804篇 |
免费 | 177篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 15篇 |
妇产科学 | 8篇 |
基础医学 | 203篇 |
口腔科学 | 13篇 |
临床医学 | 188篇 |
内科学 | 749篇 |
皮肤病学 | 29篇 |
神经病学 | 154篇 |
特种医学 | 76篇 |
外科学 | 337篇 |
综合类 | 5篇 |
预防医学 | 46篇 |
眼科学 | 6篇 |
药学 | 61篇 |
中国医学 | 2篇 |
肿瘤学 | 88篇 |
出版年
2023年 | 14篇 |
2022年 | 39篇 |
2021年 | 111篇 |
2020年 | 62篇 |
2019年 | 107篇 |
2018年 | 112篇 |
2017年 | 53篇 |
2016年 | 63篇 |
2015年 | 64篇 |
2014年 | 98篇 |
2013年 | 93篇 |
2012年 | 170篇 |
2011年 | 159篇 |
2010年 | 68篇 |
2009年 | 70篇 |
2008年 | 90篇 |
2007年 | 99篇 |
2006年 | 86篇 |
2005年 | 82篇 |
2004年 | 62篇 |
2003年 | 56篇 |
2002年 | 47篇 |
2001年 | 32篇 |
2000年 | 11篇 |
1999年 | 30篇 |
1998年 | 11篇 |
1997年 | 4篇 |
1996年 | 7篇 |
1995年 | 13篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 9篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1988年 | 7篇 |
1987年 | 6篇 |
1986年 | 3篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 4篇 |
1981年 | 3篇 |
1979年 | 3篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1969年 | 1篇 |
1968年 | 1篇 |
排序方式: 共有1989条查询结果,搜索用时 15 毫秒
71.
72.
Dougados M Braun J Szanto S Combe B Geher P Leblanc V Logeart I 《Rheumatology (Oxford, England)》2012,51(9):1687-1696
Objective. To evaluate the longer-term efficacy of etanercept in patients with severe and advanced active AS. Methods. Seventy-seven patients who completed the randomized, double-blind, placebo-controlled 12-week SPINE study enrolled in a 12-week open-label extension and received s.c. etanercept 50?mg once weekly. The etanercept/etanercept group received a total of 24 weeks treatment with etanercept (n?=?38); the placebo/etanercept group received placebo during the double-blind study then 12 weeks' etanercept treatment during the open-label extension (n?=?39). Results. At the end of the open-label extension, BASDAI scores in the etanercept/etanercept group had further decreased beyond reductions observed during the double-blind study [mean (s.d.) change from baseline -37.6 (22.4) at end of extension vs -27.4 (23.8) at end of double-blind study]. Mean (s.d.) BASDAI scores also improved in the placebo/etanercept group once switched to etanercept [-28.6 (24.3) vs -15.0 (20.0)]. Similar trends were observed in BASFI and BASMI scores. In the placebo/etanercept group, total back pain decreased to similar levels achieved in the etanercept group in the double-blind study. Pain levels continued to decrease with longer-term etanercept therapy in the etanercept/etanercept group. Conclusion. Despite the improvements in symptoms and inflammatory markers observed shortly after initiation of once-weekly etanercept, there was no notable plateauing effect on patient-reported outcomes. Indeed, signs and symptoms of severe and advanced active AS continued to improve after up to 24 weeks, treatment with etanercept. Trial registration: ClinicalTrials.gov, http://clinicaltrials.gov/ct2/home, NCT00420238. 相似文献
73.
D van der Heijde J Braun M Dougados J Sieper R Pedersen A Szumski AS Koenig 《Rheumatology (Oxford, England)》2012,51(10):1894-1905
Objectives. The Ankylosing Spondylitis Disease Activity Score (ASDAS) is a new composite clinical tool combining subjective and objective measures. Using data from the randomized double-blind Ankylosing Spondylitis Study Comparing Enbrel with Sulfasalazine Dosed Weekly (ASCEND) trial, we tested ASDAS validity and assessed its capacity to discriminate between treatment effects and change-from-baseline improvements. Methods. These post hoc analyses were conducted in patients who received etanercept (50?mg/week) or SSZ (≤3?g/day) for 16 weeks. The ASDAS was tested for its capacity to discriminate between those who achieved and did not achieve Assessment of Spondyloarthritis International Society (ASAS) partial remission and ASAS20. Week 16 adjusted treatment differences and effect sizes of improvement from baseline of 42 outcomes were calculated. Results. Means for ASDAS were less than half in patients with ASAS partial remission compared with patients without partial remission across the entire study population (1.2 vs 2.6; P?0.0001). Patients who achieved ASAS20 had greater mean changes from baseline in ASDAS than those who did not (-1.8 vs -0.3; P?0.0001). ASDAS was consistently shown to have one of the highest discriminatory capacities compared with other measurements (including subjective measurements) regardless of normal vs high CRP, presence or absence of peripheral arthritis and high vs very high ASDAS at baseline. As a dichotomous variable using different thresholds for improvement and disease severity, ASDAS had slightly better discriminatory capacity than all corresponding ASAS measures. Conclusion. ASDAS is a validated and highly discriminatory tool for the detection of significant differences between treatments for AS as well as for detecting a significant improvement from baseline with etanercept and SSZ. 相似文献
74.
Philippe Mahaudens Xavier Banse Maryline Mousny Maxime Raison Christine Detrembleur 《European spine journal》2013,22(11):2399-2406
Purpose
Adolescent idiopathic scoliotic (AIS) deformity induces excessive oxygen consumption correlated to a bilateral increase of lumbo-pelvic muscles timing activity (EMG) during gait. Wearing a brace, the usual treatment for AIS, by supporting the spine and the pelvis, would generate lumbo-pelvic muscular relaxation and consequently reduce excessive oxygen consumption. The purpose of this study was to evaluate the short-term effect of bracing on gait biomechanics in scoliotic spine when compared with normal braced spine.Methods
Thirteen healthy volunteers were compared to 13 AIS girls. In both samples, gait analysis was assessed using a three-dimensional motion analysis, including synchronous kinematic, electromyographic, mechanical and energy measurements, first without brace, then wearing a brace.Results
For scoliotic patients, comparison of in-brace and out-brace situations revealed a significant decrease of frontal pelvis (p < 0.001), hip (p < 0.001) and shoulder (p = 0.004) motion in brace associated with a significant reduction of pelvis rotation (p = 0.003). However, the brace did not change significantly the lumbo-pelvic muscle activity duration (EMG) or the mechanical and energetic parameters. Transversal pelvis motion was reduced by 39 % (p = 0.04), frontal hip and shoulder motions by 23 % (p = 0.004) and 30 % (p = 0.01) respectively, and energy cost of walking remained increased by 37 % in braced AIS girls relatively to braced healthy subjects. Mechanical and electromyographic variables were not significantly different between the two braced populations during gait except for the gluteus medius muscle that showed bilaterally an increase of duration of electrical activity in healthy subjects and contrarily a decrease in AIS patients (healthy: −3.5 ± 9.6 % of gait cycle vs. scoliotic: 3.7 ± 7.7 % of gait cycle; p = 0.04).Conclusions
Bracing changed neither the oxygen consumption nor the timing of the lumbo-pelvic muscles activity in both groups during gait. However, in brace the timing activity of bilateral gluteus medius muscles tended to decrease in AIS patients and increase in healthy subjects. Moreover, braced AIS patients had more restricted frontal hips and shoulder motion as well as pelvis rotation than braced healthy subjects. 相似文献75.
Arthroplasty for ochronotic arthritisNo failure of 11 replacements in 3 patients followed 6–12 years
Jonathan Spencer C L Maxime Gibbons Robert Sharp Andrew Carr Nicholas Athanasou 《Acta orthopaedica》2013,84(3):355-358
Background?Alkaptonuria is a rare single-gene disorder characterized by black pigmentation of cartilage and other connective tissues. Premature degenerative arthritis affects the large joints in many of these of patients. Medical treatment is limited to a protein-restricted diet (phenylalanine and tyrosine) with surgery reserved for end-stage joint disease. As in other metabolic bone diseases, there are concerns about the quality and strength of affected bones and therefore the suitability and longevity of replacement arthroplasty. The histopathology and outcome of joint replacement for alkaptonuric arthritis is unknown and limited to sporadic case reports.Patients and results?We describe 11 joint replacements in 3 patients with alkaptonuric polyarthropathy, including shoulder and elbow replacements not previously reported. No prosthetic failures occurred in up to 12 years of follow-up.Interpretation?Total joint replacement is an acceptable treatment for degenerative joint disease in alkaptonuric patients, with implant survival comparable to that found in patients with osteoarthritis. 相似文献
76.
Benoit Mesnard Maxime Leroy James Hunter Delphine Kervella Marc-Olivier Timsit Lionel Badet Pascal Glemain Emmanuel Morelon Fanny Buron Moglie Le Quintrec-Donnette Vincent Pernin Marc Ladriere Sophie Girerd Christophe Legendre Antoine Sicard Laeticia Albano Stephane De Vergie Clarisse Kerleau Thomas Prudhomme Jérôme Rigaud Diego Cantarovich Gilles Blancho Georges Karam Magali Giral Simon Ville Julien Branchereau For the Données Informatisées et VAlidées en Transplantation/Computerized VAlidated Data in Transplantation Consortium Affiliations† 《BJU international》2022,129(2):225-233
77.
Metabolic voxel‐based analysis of the complete human brain using fast 3D‐MRSI: Proof of concept in multiple sclerosis
下载免费PDF全文
![点击此处可从《Journal of magnetic resonance imaging : JMRI》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Maxime Donadieu MS Yann Le Fur PhD Angèle Lecocq PhD Andrew A. Maudsley PhD Soraya Gherib MS Elisabeth Soulier BS Sylviane Confort‐Gouny PhD Fanelly Pariollaud PhD Marie‐Pierre Ranjeva PhD Jean Pelletier MD PhD Maxime Guye MD PhD Wafaa Zaaraoui PhD Bertrand Audoin MD PhD Jean‐Philippe Ranjeva PhD 《Journal of magnetic resonance imaging : JMRI》2016,44(2):411-419
78.
79.
Near‐infrared fluorescence imaging‐guided surgery improves recurrence‐free survival rate in novel orthotopic animal model of head and neck squamous cell carcinoma
下载免费PDF全文
![点击此处可从《Head & neck》网站下载免费的PDF全文](/ch/ext_images/free.gif)
80.
Prediction of occult lymph node metastasis in squamous cell carcinoma of the oral cavity and the oropharynx using peritumoral Prospero homeobox protein 1 lymphatic nuclear quantification
下载免费PDF全文
![点击此处可从《Head & neck》网站下载免费的PDF全文](/ch/ext_images/free.gif)