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排序方式: 共有3795条查询结果,搜索用时 15 毫秒
91.
Osvaldo Vilela‐Filho Fernando P. Ferraz Breno A. Barros Luciana O. Silva Suzana F. Anunciação Joaquim T. Souza Delson J. Silva Mauricio B. Leite Ingrid B. Atayde Paulo C. Ragazzo Paula G. Barreto Mariana A. Nobrega Maisa R. Araujo Mayra R. Santos Victor H. Ala Stefano T. Queiroz 《Journal of neuroscience research》2013,91(10):1328-1337
Although long known and the most prevalent movement disorder, pathophysiology of essential tremor (ET) remains controversial. The most accepted hypothesis is that it is caused by a dysfunction of the olivocerebellar system. Vilela Filho et al. [2001; Stereotact Funct Neurosurg 77:149–150], however, reported a patient with unilateral hand ET that was completely relieved after a stroke restricted to the contralateral posterior putamen and suggested that ET could be the clinical manifestation of posterior putamen hyperactivity. The present study was designed to evaluate this hypothesis in the most often used model of ET, harmaline‐induced tremor in rats. Fifty‐four male Wistar rats were randomly distributed into three groups: experimental (EG), surgical control (SCG), and pharmacological control (PCG) groups. EG animals underwent stereotactic unilateral posterior striatotomy. SCG rats underwent sham lesion at the same target. PCG served exclusively as controls for harmaline effects. All animals received, postoperatively, intraperitoneal harmaline, and the induced tremor was video‐recorded for later evaluation by a blind observer. Thirteen animals were excluded from the study. Limb tremor was reduced ipsilaterally to the operation in 20 of 21 rats of EG and in two of nine of SCG, being asymmetric in one of 10 of PCG rats. Comparisons between EG × SCG and EG × PCG were statistically significant, but not between SCG × PCG. Limb tremor reduction was greater in anterior than in posterior paws. Lateral lesions yielded better results than medial lesions. These results suggest that the posterior striatum is involved with harmaline‐induced tremor in rats and support the hypothesis presented. © 2013 Wiley Periodicals, Inc. 相似文献
92.
Andrea H. Lewis Michael A. Niznikiewicz Andrew R. Delamater Mauricio R. Delgado 《The European journal of neuroscience》2013,38(12):3740-3748
The Pavlovian‐to‐instrumental transfer (PIT) paradigm probes the influence of Pavlovian cues over instrumentally learned behavior. The paradigm has been used extensively to probe basic cognitive and motivational processes in studies of animal learning. More recently, PIT and its underlying neural basis have been extended to investigations in humans. These initial neuroimaging studies of PIT have focused on the influence of appetitively conditioned stimuli on instrumental responses maintained by positive reinforcement, and highlight the involvement of the striatum. In the current study, we sought to understand the neural correlates of PIT in an aversive Pavlovian learning situation when instrumental responding was maintained through negative reinforcement. Participants exhibited specific PIT, wherein selective increases in instrumental responding to conditioned stimuli occurred when the stimulus signaled a specific aversive outcome whose omission negatively reinforced the instrumental response. Additionally, a general PIT effect was observed such that when a stimulus was associated with a different aversive outcome than was used to negatively reinforce instrumental behavior, the presence of that stimulus caused a non‐selective increase in overall instrumental responding. Both specific and general PIT behavioral effects correlated with increased activation in corticostriatal circuitry, particularly in the striatum, a region involved in cognitive and motivational processes. These results suggest that avoidance‐based PIT utilizes a similar neural mechanism to that seen with PIT in an appetitive context, which has implications for understanding mechanisms of drug‐seeking behavior during addiction and relapse. 相似文献
93.
94.
Díaz de León-Navarro RJ Sánchez-Aguilar JM Franco-Garrocho M Shiguetomi-Medina JM Tapia-Pérez JH 《Gaceta médica de México》2007,143(6):477-481
INTRODUCTION: The transplantation program of organs obtained from deceased donors requires a complex structural organization. Medical, logistic, and cultural aspects must be taken into account. MATERIAL AND METHODS: We analyzed the detection of possible organ donors in San Luis Potosí, Mexico, from August 21, 1999 to August 30, 2002. We studied the main causes of brain death, donor conversion, legal implications, reasons for donation and refusal to donate. RESULTS: 71.42% of donors and 64.15% of non donors required legal intervention. The main cause of brain death was brain traumatic injury (66.97%). The donation rate per one million inhabitants was 8.3. CONCLUSIONS: Adequate forensic management has a positive influence on achieved deceased donors. An effective team work and coordination with the State Council of Transplants has allowed the State of San Luis Potosí to have the highest rate of organ donation in Mexico. 相似文献
95.
Quintero-Hernández V Juárez-González VR Ortíz-León M Sánchez R Possani LD Becerril B 《Molecular immunology》2007,44(6):1307-1315
The antigen-binding fragment (Fab) has been considered a more functionally stable version of recombinant antibodies than single chain antibody fragments (scFvs), however this intuitive consideration has not been sufficiently proven in vivo. This communication shows that three out of four specific scFvs against a scorpion toxin, with different affinities and stabilities, become neutralizing in vivo when expressed as Fabs, despite the fact that they are not neutralizing in the scFv format. A scFv fragment previously obtained from a neutralizing mouse antibody (BCF2) was used to produce three derived scFvs by directed evolution. Only one of them was neutralizing, however when expressed as Fab, all of them became neutralizing fragments in vivo. The initial scFvBCF2 (earlier used for directed evolution) was not neutralizing in the scFv format. After expressing it as Fab did not become a neutralizing fragment, but did reduce the intoxication symptoms of experimental mice. The stability of the four Fabs derived from their respective scFvs was improved when tested in the presence of guanidinium chloride. The in vitro stability of the Fab format has been shown earlier, but the physiological consequences of this stability are shown in this communication. The present results indicate that improved functional stability conferred by the Fab format can replace additional maturation steps, when the affinity and stability are close to the minimum necessary to be neutralizing. 相似文献
96.
Garland SM Hernandez-Avila M Wheeler CM Perez G Harper DM Leodolter S Tang GW Ferris DG Steben M Bryan J Taddeo FJ Railkar R Esser MT Sings HL Nelson M Boslego J Sattler C Barr E Koutsky LA;Females United to Unilaterally Reduce Endo/Ectocervical Disease 《The New England journal of medicine》2007,356(19):1928-1943
97.
98.
Ramirez-Sandoval Juan C. Diener-Cabieses Pablo Gutiérrez-Valle Fabián Ley-Tapia Sofía Pastrana-Brandes Santiago Galindo Pablo E. Fagundo Reynerio Moreno-Yañez Mauricio Reza-Albarrán Alfredo Adolfo Correa-Rotter Ricardo 《International urology and nephrology》2022,54(10):2625-2635
International Urology and Nephrology - Free calcium is the gold standard for diagnosis of calcium disorders, although calcium assessment is routinely performed by albumin-adjusted calcium. Our... 相似文献
99.
Jacob Matthew Eckstein Nicole Nolan Erin Healy Chadwick Lewis Wright Angita Jain Christian Louis Barney Iman Washington Joseph Paul McElroy John Christopher Grecula Jessica Lynn Wobb Darrion Luther Mitchell Eric Miller Mauricio Gamez Dukagjin Blakaj Virginia Diavolitsis Aashish Bhatt 《Head & neck》2020,42(9):2405-2413