全文获取类型
收费全文 | 4751篇 |
免费 | 340篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 36篇 |
儿科学 | 178篇 |
妇产科学 | 60篇 |
基础医学 | 744篇 |
口腔科学 | 38篇 |
临床医学 | 520篇 |
内科学 | 1057篇 |
皮肤病学 | 70篇 |
神经病学 | 628篇 |
特种医学 | 228篇 |
外国民族医学 | 10篇 |
外科学 | 563篇 |
综合类 | 18篇 |
一般理论 | 1篇 |
预防医学 | 366篇 |
眼科学 | 59篇 |
药学 | 240篇 |
中国医学 | 1篇 |
肿瘤学 | 282篇 |
出版年
2023年 | 33篇 |
2022年 | 56篇 |
2021年 | 139篇 |
2020年 | 67篇 |
2019年 | 126篇 |
2018年 | 167篇 |
2017年 | 112篇 |
2016年 | 130篇 |
2015年 | 150篇 |
2014年 | 193篇 |
2013年 | 221篇 |
2012年 | 303篇 |
2011年 | 267篇 |
2010年 | 171篇 |
2009年 | 156篇 |
2008年 | 210篇 |
2007年 | 227篇 |
2006年 | 198篇 |
2005年 | 167篇 |
2004年 | 156篇 |
2003年 | 147篇 |
2002年 | 134篇 |
2001年 | 110篇 |
2000年 | 94篇 |
1999年 | 113篇 |
1998年 | 40篇 |
1997年 | 33篇 |
1996年 | 28篇 |
1995年 | 25篇 |
1994年 | 27篇 |
1993年 | 29篇 |
1992年 | 70篇 |
1991年 | 71篇 |
1990年 | 83篇 |
1989年 | 76篇 |
1988年 | 75篇 |
1987年 | 43篇 |
1986年 | 64篇 |
1985年 | 60篇 |
1984年 | 56篇 |
1983年 | 58篇 |
1982年 | 37篇 |
1981年 | 22篇 |
1979年 | 42篇 |
1978年 | 33篇 |
1977年 | 29篇 |
1975年 | 29篇 |
1974年 | 27篇 |
1972年 | 25篇 |
1970年 | 23篇 |
排序方式: 共有5099条查询结果,搜索用时 218 毫秒
91.
Haruka Sasaki Murugasu Nagulesparan Andre Dubois Barbara Vasquez Eugene Straus Maurice L. Sievers Roger H. Unger 《Digestive diseases and sciences》1983,28(6):502-506
Intragastric glucose inhibits gastric acid secretion and gastric emptying in man. To determine if these effects are mediated by somatostatin—a known inhibitor of gastric acid production, gastrin secretion, and gastric motility—the plasma somatostatin-like immunoreactivity (SLI) levels were determined in healthy human subjects after an intragastric load of 30% glucose solution. These findings were compared with results after an instillation of distilled water. Following the glucose load, the intragastric acid concentration, the acid output, and the fractional gastric emptying rate declined significantly (P<0.01) before either the plasma glucose or plasma insulin levels had increased. Neither the gastrin nor SLI plasma concentrations changed after the water or glucose load. These findings suggest that the suppression of gastric acid secretion and inhibition of the rate of gastric emptying that occur with intragastric glucose are mediated by factors other than changes in the peripheral circulating levels of SLI, gastrin, insulin, or glucose. 相似文献
92.
Etienne Gayat Alexa Hollinger Alain Cariou Nicolas Deye Antoine Vieillard-Baron Samir Jaber Benjamin G. Chousterman Qin Lu Pierre François Laterre Xavier Monnet Michael Darmon Marc Leone Bertrand Guidet Romain Sonneville Jean-Yves Lefrant Marie-Céline Fournier Matthieu Resche-Rigon Alexandre Mebazaa Matthieu Legrand On behalf of FROG-ICU investigators 《Intensive care medicine》2018,44(5):598-605
93.
Matthieu Jabaudon Raiko Blondonnet Bruno Pereira Rodrigo Cartin-Ceba Christoph Lichtenstern Tommaso Mauri Rogier M. Determann Tomas Drabek Rolf D. Hubmayr Ognjen Gajic Florian Uhle Andrea Coppadoro Antonio Pesenti Marcus J. Schultz Marco V. Ranieri Helena Brodska Ségolène Mrozek Vincent Sapin Michael A. Matthay Jean-Michel Constantin Carolyn S. Calfee 《Intensive care medicine》2018,44(9):1388-1399
Purpose
The soluble receptor for advanced glycation end-products (sRAGE) is a marker of lung epithelial injury and alveolar fluid clearance (AFC), with promising values for assessing prognosis and lung injury severity in acute respiratory distress syndrome (ARDS). Because AFC is impaired in most patients with ARDS and is associated with higher mortality, we hypothesized that baseline plasma sRAGE would predict mortality, independently of two key mediators of ventilator-induced lung injury.Methods
We conducted a meta-analysis of individual data from 746 patients enrolled in eight prospective randomized and observational studies in which plasma sRAGE was measured in ARDS articles published through March 2016. The primary outcome was 90-day mortality. Using multivariate and mediation analyses, we tested the association between baseline plasma sRAGE and mortality, independently of driving pressure and tidal volume.Results
Higher baseline plasma sRAGE [odds ratio (OR) for each one-log increment, 1.18; 95% confidence interval (CI) 1.01–1.38; P?=?0.04], driving pressure (OR for each one-point increment, 1.04; 95% CI 1.02–1.07; P?=?0.002), and tidal volume (OR for each one-log increment, 1.98; 95% CI 1.07–3.64; P?=?0.03) were independently associated with higher 90-day mortality in multivariate analysis. Baseline plasma sRAGE mediated a small fraction of the effect of higher ΔP on mortality but not that of higher VT.Conclusions
Higher baseline plasma sRAGE was associated with higher 90-day mortality in patients with ARDS, independently of driving pressure and tidal volume, thus reinforcing the likely contribution of alveolar epithelial injury as an important prognostic factor in ARDS. Registration: PROSPERO (ID: CRD42018100241).94.
95.
96.
97.
Martyn Wood Vanessa Dubois Dieter Scheller Michel Gillard 《British journal of pharmacology》2015,172(4):1124-1135
Background and Purpose
Rotigotine acts as a dopamine receptor agonist with high affinity for the dopamine D2, D3, D4 and D5 receptors but with a low affinity for the dopamine D1 receptor. We have investigated this further in radioligand binding and functional studies and compared the profile of rotigotine with that of other drugs used in the treatment of Parkinson''s disease (PD).Experimental Approach
The binding of rotigotine to human dopamine D1, D2, D3, D4 and D5 receptors was determined in radioligand binding studies using [3H]rotigotine and compared with that of standard antagonist radioligands. Functional interactions of rotigotine with human dopamine receptors was also determined.Key Results
[3H]rotigotine can be used as an agonist radioligand to label all dopamine receptor subtypes and this can be important to derive agonist affinity estimates. Rotigotine maintains this high affinity in functional studies at all dopamine receptors especially D1, D2 and D3 receptors and, to a lesser extent, D4 and D5 receptors. Rotigotine, like apomorphine but unlike ropinirole and pramipexole, was a potent agonist at all dopamine receptors.Conclusions and Implications
Rotigotine is a high-potency agonist at human dopamine D1, D2 and D3 receptors with a lower potency at D4 and D5 receptors. These studies differentiate rotigotine from conventional dopamine D2 agonists, used in the treatment of PD, such as ropinirole and pramipexole which lack activity at the D1 and D5 receptors, but resembles that of apomorphine which has greater efficacy in PD than other dopamine agonists but has suboptimal pharmacokinetic properties. 相似文献98.
Florence Pilate Zhi-Bin Wen Farid Khelifa Yan Hui Sebastien Delpierre Luo Dan Rosica Mincheva Philippe Dubois Ke-Ke Yang Jean-Marie Raquez 《RSC advances》2018,8(48):27119
A novel poly(epsilon-caprolactone) (PCL) supramolecular network exhibiting shape-memory behavior was successfully constructed with pendant UPy units that are highly able to dimerize. The dynamic network was obtained by a simple and versatile strategy consisting of chain-extension reaction between α,ω-dihydroxyoligoPCL and hydroxylated UPy units in the presence of hexamethylene diisocyanate as a coupling agent and further intermolecular dimerization of the UPy along the polyurethane backbone. 1H NMR analyses confirmed the dynamic features of the system, and DMTA in tensile mode was investigated to assess the SMP properties. Recyclability was also assessed by taking advantage of these supramolecular networks. Further addition of cellulose nanocrystals into the polymer network enabled adjustment of the extent of the net-points and therefore the SMP features. As confirmed by dispersion tests in solution and SEM observations, these bio-based nanofillers were homogeneously distributed in the network via supramolecular interaction between the hydroxyl groups present on their surface and UPy moieties along the polyurethane backbone. Thus, the here developed nanomaterials might reveal applicability in areas where a combination of SMP and biocompatibility is needed.Novel melt-recyclable poly(ε-caprolactone)/cellulose nanocrystals supramolecular nanocomposite networks with shape-memory behavior have been successfully constructed by playing with UPy chemistry. 相似文献
99.
Bruno Scherrer S. Andrieu P.-J. Ousset G. Berrut J.-F. Dartigues B. Dubois F. Pasquier F. Piette P. Robert J. Touchon P. Garnier H. Mathiex-Fortunet B. Vellas The Guidage Study Group 《The journal of nutrition, health & aging》2015,19(10):1009-1011
Time-to-event analysis is frequently used in medical research to investigate potential diseasemodifying treatments in neurodegenerative diseases. Potential treatment effects are generally evaluated using the logrank test, which has optimal power and sensitivity when the treatment effect (hazard ratio) is constant over time. However, there is generally no prior information as to how the hazard ratio for the event of interest actually evolves. In these cases, the logrank test is not necessarily the most appropriate to use. When the hazard ratio is expected to decrease or increase over time, alternative statistical tests such as the Fleming-Harrington test, provide a better sensitivity. An example of this comes from a large, five-year randomised, placebo-controlled prevention trial (GuidAge) in 2854 community-based subjects making spontaneous memory complaints to their family physicians, which evaluated whether treatment with EGb761® can modify the risk of developing AD. The primary outcome measure was the time to conversion from memory complaint to Alzheimer’s type dementia. Although there was no significant difference in the hazard function of conversion between the two treatment groups according to the preplanned logrank test, a significant treatment-by-time interaction for the incidence of AD was observed in a protocol-specified subgroup analysis, suggesting that the hazard ratio is not constant over time. For this reason, additional post hoc analyses were performed using the Fleming-Harrington test to evaluate whether there was a signal of a late effect of EGb761®. Applying the Fleming-Harrington test, the hazard function for conversion to dementia in the placebo group was significantly different from that in the EGb761® treatment group (p = 0.0054), suggesting a late effect of EGb761®. Since this was a post hoc analysis, no definitive conclusions can be drawn as to the effectiveness of the treatment. This post hoc analysis illustrates the interest of performing another randomised clinical trial of EGb761® explicitly testing the hypothesis of a late treatment effect, as well as of using of better adapted statistical approaches for long term preventive trials when it is expected that prevention cannot have an immediate effect but rather a delayed effect that increases over time. 相似文献
100.
Ultralow temperature cryoablation: Safety and efficacy of preclinical atrial and ventricular lesions
Felix Bourier MD Masateru Takigawa MD PhD Anna Lam MD Konstantinos Vlachos MD F. Daniel Ramirez MD MSc Claire A. Martin MD Antonio Frontera MD PhD Takeshi Kitamura MD Josselin Duchateau MD Thomas Pambrun MD Nicolas Derval MD Arnaud Denis MD Jerry Cox MD David Cabrita MD Alexander Babkin PhD Marion Constantin MA Pierre Jais MD Frédéric Sacher MD PhD Rémi Dubois MD PhD Oliver Bernus PhD Michel Haissaguerre MD Mélèze Hocini MD 《Journal of cardiovascular electrophysiology》2021,32(3):570-577