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排序方式: 共有7558条查询结果,搜索用时 15 毫秒
111.
Giulia Rivasi MD Matteo Bulgaresi MD Chiara Bandinelli MD Daniela Balzi BSc Francesca Tarantini PhD Silvia Tognelli MD Chiara Lorini PhD Primo Buscemi MD Lorenzo Baggiani MD Giancarlo Landini MD Andrea Ungar PhD Guglielmo Bonaccorsi MD Enrico Mossello PhD Enrico Benvenuti MD 《Journal of the American Geriatrics Society》2022,70(5):1336-1341
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Gagliardi Federica Lauro Augusto Tripodi Domenico Amabile Maria Ida Palumbo Piergaspare Di Matteo Filippo Maria Palazzini Giorgio Forte Flavio Frattaroli Stefano Khouzam Simone Marino Ignazio R. DAndrea Vito Sorrenti Salvatore Pironi Daniele 《Digestive diseases and sciences》2022,67(3):786-798
Digestive Diseases and Sciences - Mesenteric cysts are defined as a heterogeneous group of intra-abdominal cystic lesions of the mesentery or omentum that may be found in any portion of the... 相似文献
114.
Irene Paganini Vivian Y Chang Gabriele L Capone Jeremie Vitte Matteo Benelli Lorenzo Barbetti Roberta Sestini Eva Trevisson Theo JM Hulsebos Marco Giovannini Stanley F Nelson Laura Papi 《European journal of human genetics : EJHG》2015,23(7):963-968
Schwannomatosis is characterized by the development of multiple non-vestibular, non-intradermal schwannomas. Constitutional inactivating variants in two genes, SMARCB1 and, very recently, LZTR1, have been reported. We performed exome sequencing of 13 schwannomatosis patients from 11 families without SMARCB1 deleterious variants. We identified four individuals with heterozygous loss-of-function variants in LZTR1. Sequencing of the germline of 60 additional patients identified 18 additional heterozygous variants in LZTR1. We identified LZTR1 variants in 43% and 30% of familial (three of the seven families) and sporadic patients, respectively. In addition, we tested LZTR1 protein immunostaining in 22 tumors from nine unrelated patients with and without LZTR1 deleterious variants. Tumors from individuals with LZTR1 variants lost the protein expression in at least a subset of tumor cells, consistent with a tumor suppressor mechanism. In conclusion, our study demonstrates that molecular analysis of LZTR1 may contribute to the molecular characterization of schwannomatosis patients, in addition to NF2 mutational analysis and the detection of chromosome 22 losses in tumor tissue. It will be especially useful in differentiating schwannomatosis from mosaic Neurofibromatosis type 2 (NF2). However, the role of LZTR1 in the pathogenesis of schwannomatosis needs further elucidation. 相似文献
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Mohamed Bekheit Matteo Catanzano Stuart Shand Irfan Ahmed ELSaid ELKayal Gihan Mohamed Shehata Adel Zaki 《Hepatobiliary & pancreatic diseases international : HBPD INT》2019,18(1):4-11
Background
Liver transplant is a potential cure for liver failure and hepatic malignancy but there are many techniques which have been described for vascular reconstruction. This study was to compare the prevalence of non-anastomotic biliary stricture and other surgical complications based on Clavien-Dindo scoring system, in initial portal reperfusion (sequential) versus simultaneous or initial artery reperfusion.Data sources
Meta-analysis of published studies comparing the outcomes of both techniques was carried out. Data search was conducted across the major databases and studies were selected under the guidance of the Cochrane guidelines for systematic reviews and meta-analysis.Results
Seven studies were included to address the primary and the secondary outcomes. No statistical difference was found in the incidence of non-anastomotic biliary strictures (OR?=?0.40; P?=?0.14), regardless of reperfusion technique. The pooled estimate of the Clavien-Dindo grading of complications was not significantly different between the techniques, though Clavien-Dindo II complications were higher in the simultaneous or initial artery reperfusion group than the initial portal reperfusion group (OR?=?2.73; P?=?0.01). Similarly, there was no difference in the operative time, hospital stay and other outcomes addressed in this report.Conclusions
The available evidence suggests that there is no significant difference demonstrated in the rate of non-anastomotic biliary strictures or other complications, between the two techniques, except for Clavien-Dindo II complications. 相似文献116.
Gelardi Matteo Ciprandi Giorgio Incorvaia Cristoforo Buttafava Serena Leo Eleonora Iannuzzi Lucia Quaranta Nicola Frati Franco 《Inflammation research》2015,64(6):373-375
Inflammation Research - Allergic rhinitis (AR) is characterized by typical symptoms that are dependent on inflammation. Poly-allergy is a frequent phenomenon. Phenotyping AR represents an... 相似文献
117.
Davide Porrelli Andrea Travan Gianluca Turco Matteo Crosera Massimiliano Borgogna Ivan Donati Sergio Paoletti Gianpiero Adami Eleonora Marsich 《Journal of tissue engineering and regenerative medicine》2018,12(2):e747-e759
Injectable bone fillers represent an attractive strategy for the treatment of bone defects. These injectable materials should be biocompatible, capable of supporting cell growth and possibly able to exert antibacterial effects. In this work, nanocomposite microbeads based on alginate, chitlac, hydroxyapatite and silver nanoparticles were prepared and characterized. The dried microbeads displayed a rapid swelling in contact with simulated body fluid and maintained their integrity for more than 30 days. The evaluation of silver leakage from the microbeads showed that the antibacterial metal is slowly released in saline solution, with less than 6% of silver released after 1 week. Antibacterial tests proved that the microbeads displayed bactericidal effects toward Staphylococcus aureus, Pseudomonas aeruginosa and Staphylococcus epidermidis, and were also able to damage pre‐formed bacterial biofilms. On the other hand, the microbeads did not exert any cytotoxic effect towards osteoblast‐like cells. After characterization of the microbeads bioactivity, a possible means to embed them in a fluid medium was explored in order to obtain an injectable paste. Upon suspension of the particles in alginate solution or alginate/hyaluronic acid mixtures, a homogenous and time‐stable paste was obtained. Mechanical tests enabled to quantify the extrusion forces from surgical syringes, pointing out the proper injectability of the material. This novel antibacterial bone filler appears as a promising material for the treatment of bone defects, in particular when possible infections could compromise the bone‐healing process. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献
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Mitral regurgitation severity correlates with symptoms and extent of left atrial dysfunction: Effect of mitral valve repair
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Matteo Lisi MD Matteo Cameli MD Cristina Di Tommaso MD Valeria Curci MD Rosanna Reccia MD Flavio D'ascenzi MD Marta Focardi PhD Massimo Maccherini MD Mario Chiavarelli MD Gianfranco Lisi MD Per Lindqvist PhD Sergio Mondillo MD Michael Henein MD PhD 《Journal of clinical ultrasound : JCU》2018,46(1):32-40