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排序方式: 共有5341条查询结果,搜索用时 15 毫秒
941.
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Marijke De Bock Maxime Culot Nan Wang M��lissa Bol Elke Decrock Elke De Vuyst Anaelle da Costa Ine Dauwe Mathieu Vinken Alexander M Simon Vera Rogiers Gaspard De Ley William Howard Evans Geert Bultynck Genevi��ve Dupont Romeo Cecchelli Luc Leybaert 《Journal of cerebral blood flow and metabolism》2011,31(9):1942-1957
The cytoplasmic Ca2+ concentration ([Ca2+]i) is an important factor determining the functional state of blood–brain barrier (BBB) endothelial cells but little is known on the effect of dynamic [Ca2+]i changes on BBB function. We applied different agonists that trigger [Ca2+]i oscillations and determined the involvement of connexin channels and subsequent effects on endothelial permeability in immortalized and primary brain endothelial cells. The inflammatory peptide bradykinin (BK) triggered [Ca2+]i oscillations and increased endothelial permeability. The latter was prevented by buffering [Ca2+]i with BAPTA, indicating that [Ca2+]i oscillations are crucial in the permeability changes. Bradykinin-triggered [Ca2+]i oscillations were inhibited by interfering with connexin channels, making use of carbenoxolone, Gap27, a peptide blocker of connexin channels, and Cx37/43 knockdown. Gap27 inhibition of the oscillations was rapid (within minutes) and work with connexin hemichannel-permeable dyes indicated hemichannel opening and purinergic signaling in response to stimulation with BK. Moreover, Gap27 inhibited the BK-triggered endothelial permeability increase in in vitro and in vivo experiments. By contrast, [Ca2+]i oscillations provoked by exposure to adenosine 5′ triphosphate (ATP) were not affected by carbenoxolone or Gap27 and ATP did not disturb endothelial permeability. We conclude that interfering with endothelial connexin hemichannels is a novel approach to limiting BBB-permeability alterations. 相似文献
944.
Nelissen N Dupont P Vandenbulcke M Tousseyn T Peeters R Vandenberghe R 《Journal of molecular neuroscience : MN》2011,45(3):637-647
Right hemisphere recruitment of areas homotopical to affected left-sided language areas has classically been described in
aphasia following stroke or brain tumors. It may also be a clinically significant mechanism in frontotemporal lobar degeneration
(FTLD) and Alzheimer’s disease (AD). In a pooled analysis of previous functional magnetic resonance imaging studies of a modified
version of the Pyramids and Palm Trees test, we probed the language network in 19 patients with primary progressive aphasia
(nine semantic (SV) and ten agrammatic variant; neuropathologically confirmed FTLD in three cases to date), 15 patients with
AD (14 clinically probable and one neuropathologically definite AD to date), and 37 healthy controls. The upper and lower
bank of the left posterior superior temporal sulcus (STS) was affected in AD and the left anterior temporal pole (ATP) in
primary progressive aphasia (PPA; mainly driven by SV). In the right hemisphere, the posterior STS showed an activity increase
in both patient groups compared with controls. In AD, this activity increase correlated positively with naming accuracy. Both
in AD and in PPA, the connection strength between right STS and right ATP was decreased compared with controls and this correlated
with naming and comprehension scores, respectively. Only in PPA did the right anterior temporal pole show an activity increase,
which correlated negatively with comprehension. Right-hemispheric recruitment and disconnections within the right temporal
lobe may affect the degree of aphasia in cortical neurodegenerative disease. 相似文献
945.
Courtin C Jobard G Vigneau M Beaucousin V Razafimandimby A Hervé PY Mellet E Zago L Petit L Mazoyer B Tzourio-Mazoyer N 《Brain research bulletin》2011,84(1):75-87
We used functional magnetic resonance imaging to investigate the areas activated by signed narratives in non-signing subjects naïve to sign language (SL) and compared it to the activation obtained when hearing speech in their mother tongue. A subset of left hemisphere (LH) language areas activated when participants watched an audio-visual narrative in their mother tongue was activated when they observed a signed narrative. The inferior frontal (IFG) and precentral (Prec) gyri, the posterior parts of the planum temporale (pPT) and of the superior temporal sulcus (pSTS), and the occipito-temporal junction (OTJ) were activated by both languages. The activity of these regions was not related to the presence of communicative intent because no such changes were observed when the non-signers watched a muted video of a spoken narrative. Recruitment was also not triggered by the linguistic structure of SL, because the areas, except pPT, were not activated when subjects listened to an unknown spoken language. The comparison of brain reactivity for spoken and sign languages shows that SL has a special status in the brain compared to speech; in contrast to unknown oral language, the neural correlates of SL overlap LH speech comprehension areas in non-signers. These results support the idea that strong relationships exist between areas involved in human action observation and language, suggesting that the observation of hand gestures have shaped the lexico-semantic language areas as proposed by the motor theory of speech. As a whole, the present results support the theory of a gestural origin of language. 相似文献
946.
Tanja Schmitz‐Hübsch Mathieu Coudert Sophie Tezenas du Montcel Paola Giunti Robyn Labrum Alexandra Dürr Pascale Ribai Perrine Charles Christoph Linnemann Ludger Schls Maryla Rakowicz Rafal Rola Elszbieta Zdzienicka Roberto Fancellu Caterina Mariotti Lazlo Baliko Bela Melegh Alessandro Filla Elena Salvatore Bart P.C. van de Warrenburg Sandra Szymanski Jon Infante Dagmar Timmann Sylvia Boesch Chantal Depondt Jun‐Suk Kang Jrg B. Schulz Thomas Klopstock Nicole Lossnitzer Bernd Lwe Caroline Frick Daniela Rottlnder Thomas E. Schlaepfer Thomas Klockgether 《Movement disorders》2011,26(5):870-876
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Delphine Detaint Philippe Aegerter Florence Tubach Isabelle Hoffman Henri Plauchu Yves Dulac Laurence Olivier Faivre Marie-Ange Delrue Patrick Collignon Sylvie Odent Maria Tchitchinadze Catherine Bouffard Florence Arnoult Mathieu Gautier Catherine Boileau Guillaume Jondeau 《Archives of Cardiovascular Diseases》2010,103(5):317-325