全文获取类型
收费全文 | 13554篇 |
免费 | 687篇 |
国内免费 | 101篇 |
专业分类
耳鼻咽喉 | 79篇 |
儿科学 | 210篇 |
妇产科学 | 299篇 |
基础医学 | 1788篇 |
口腔科学 | 324篇 |
临床医学 | 833篇 |
内科学 | 3282篇 |
皮肤病学 | 384篇 |
神经病学 | 1197篇 |
特种医学 | 789篇 |
外科学 | 2348篇 |
综合类 | 33篇 |
一般理论 | 1篇 |
预防医学 | 341篇 |
眼科学 | 169篇 |
药学 | 828篇 |
中国医学 | 19篇 |
肿瘤学 | 1418篇 |
出版年
2023年 | 67篇 |
2022年 | 126篇 |
2021年 | 263篇 |
2020年 | 169篇 |
2019年 | 217篇 |
2018年 | 240篇 |
2017年 | 185篇 |
2016年 | 218篇 |
2015年 | 233篇 |
2014年 | 317篇 |
2013年 | 385篇 |
2012年 | 631篇 |
2011年 | 709篇 |
2010年 | 407篇 |
2009年 | 327篇 |
2008年 | 665篇 |
2007年 | 716篇 |
2006年 | 685篇 |
2005年 | 700篇 |
2004年 | 695篇 |
2003年 | 783篇 |
2002年 | 769篇 |
2001年 | 383篇 |
2000年 | 434篇 |
1999年 | 313篇 |
1998年 | 180篇 |
1997年 | 142篇 |
1996年 | 132篇 |
1995年 | 118篇 |
1994年 | 112篇 |
1993年 | 95篇 |
1992年 | 252篇 |
1991年 | 254篇 |
1990年 | 222篇 |
1989年 | 277篇 |
1988年 | 222篇 |
1987年 | 231篇 |
1986年 | 197篇 |
1985年 | 158篇 |
1984年 | 110篇 |
1983年 | 92篇 |
1982年 | 57篇 |
1979年 | 83篇 |
1978年 | 80篇 |
1977年 | 59篇 |
1975年 | 52篇 |
1974年 | 52篇 |
1972年 | 60篇 |
1971年 | 55篇 |
1968年 | 53篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
Takahiro Namiki Chika Takano Ryoji Aoki Quang Duy Trinh Ichiro Morioka Satoshi Hayakawa 《Congenital anomalies》2022,62(1):38-41
Congenital rubella syndrome (CRS) results from maternal rubella virus infection in early pregnancy. Abnormal neuroimaging findings have been analyzed in a small number of CRS patients in the past; however, their clinical significance has been poorly addressed. Therefore, we have investigated the neuroimaging findings of 31 patients with CRS from previous studies. The most common finding was parenchymal calcification, which was observed in 18 of 31 patients (58.1%). A multivariable logistic regression model showed that it was associated with psychomotor or mental retardation (p = 0.018), suggesting that parenchymal calcification in CRS could be a prognostic factor. 相似文献
4.
5.
6.
Taisuke Inada Satoshi Fukushima Masayuki Murai Masatoshi Jinnin Azusa Miyashita Satoshi Nakahara Junji Yamashita Jun Aoi Shinichi Masuguchi Hironobu Ihn 《The Journal of dermatology》2015,42(2):198-201
miRNA‐221 (miR‐221) is known to be abnormally expressed in many human cancers. The serum levels of miR‐221 have been reported as a tumor marker for malignant melanoma (MM). We hypothesized that the hair shaft miR‐221 levels may be increased in patients with MM. We therefore assessed the possibility that hair shaft miR‐221 levels could be a marker for MM. The hair shaft miR‐221 levels were significantly higher in patients with MM than controls. The rates of increased hair shaft miR‐221 levels above the cut‐off value were comparable to those of serum 5‐S‐CD, which is a tumor marker commonly used for MM. Measurements of the hair shaft miR‐221 levels could have potential clinical value in the detection of MM. This is the first report investigating the hair shaft levels of an miRNA in patients with MM. Our investigations offer new insight into the relationship between miR‐221 and MM, and may provide a new, non‐invasive way to screen for melanoma. 相似文献
7.
8.
9.
Masahiro Yamauchi Hiroko Kusano Etsuko Saito Takeshi Iwata Masashi Nakakura Yasuki Kato Takaaki Uochi Shiro Akinaga Noboru Aoki 《Journal of controlled release》2006,114(2):268-275
Previously, we demonstrated that wrapping dextran fluorescein anionic/cationic lipid complexes with neutral lipids produced a stable formulation that markedly increased the duration of the compound in plasma after intravenous administration to rats. The improved drug-delivery properties of the wrapped liposomes (WL) relative to other formulations suggested that this technology could offer important advantages for the administration of other polyanionic drugs, including antisense oligodeoxynucleotides (ODN). In the present study, we investigated the value of WL for formulating fluorescence-labeled phosphorothioated ODN (F-ODN). WL encapsulating F-ODN/cationic lipid complexes were prepared efficiently using similar methodology to that used in our earlier study. Studies confirmed that these WL were stable in vitro. Following intravenous administration to mice, free F-ODN and naked F-ODN/cationic lipid complexes were rapidly eliminated whereas administration of the WL resulted in high blood concentrations of drug that were maintained for several hours. Additional studies were conducted in mice that were inoculated with tumor cells (Caki-1 xenograft model, human kidney); in these experiments, intravenous administration of WL delivered 13 times more F-ODN to the tumor site than achieved after injection of free F-ODN. 相似文献
10.
Akira Sawaki Nobumasa Mizuno Kuniyuki Takahashi Tsuneya Nakamura Masahiro Tajika Hiroki Kawai Toshifumi Isaka Hiroshi Imaoka Yasuyuki Okamoto Masatoshi Aoki Hiroyuki Inoue Ahmed AS Salem Yasushi Yatabe Kenji Yamao 《Digestive endoscopy》2006,18(1):40-44
Background: Gastrointestinal stromal tumors (GIST) are one of the most common mesenchymal tumors of the gastrointestinal tract. GIST are defined by positive immunohistochemical staining for KIT or CD34 and thus are generally diagnosed after surgery. Because small GIST are rarely diagnosed before surgery, the clinical course of these small tumors is not clear. The aim of the present study was to follow changes in size and configuration of small GIST that were pathologically confirmed using endoscopic ultrasonography‐guided fine‐needle aspiration biopsy (EUS‐FNAB). Methods: Between July 1997 and December 2003, 16 tumors in 16 patients (10 men and 6 women) with an immunohistochemical diagnosis of GIST were regularly followed in our hospital. The median patient age when EUS‐FNAB was performed was 62 years (range 26–82 years) and the median follow‐up period was 4.9 years (range 0.5–9.6 years). Results: Fourteen tumors showed no remarkable changes in size and shape during follow up compared with the initial diagnosis. Two tumors enlarged: one tumor approximately doubled its diameter in 8 years and the other tumor increased from 1.8 cm at diagnosis to up to 10 cm after only 2 years. Doubling time of the latter tumor was calculated as 3.1 months. Conclusions: We conclude that EUS‐FNAB might be a good modality for final diagnosis of GIST without surgery, and that GIST without rapid growth on follow up can be endoscopically followed. 相似文献