全文获取类型
收费全文 | 8778篇 |
免费 | 423篇 |
国内免费 | 73篇 |
专业分类
耳鼻咽喉 | 87篇 |
儿科学 | 170篇 |
妇产科学 | 84篇 |
基础医学 | 1029篇 |
口腔科学 | 149篇 |
临床医学 | 593篇 |
内科学 | 2161篇 |
皮肤病学 | 106篇 |
神经病学 | 636篇 |
特种医学 | 351篇 |
外科学 | 1939篇 |
综合类 | 26篇 |
现状与发展 | 1篇 |
预防医学 | 158篇 |
眼科学 | 135篇 |
药学 | 565篇 |
中国医学 | 8篇 |
肿瘤学 | 1076篇 |
出版年
2024年 | 4篇 |
2023年 | 71篇 |
2022年 | 138篇 |
2021年 | 205篇 |
2020年 | 124篇 |
2019年 | 167篇 |
2018年 | 203篇 |
2017年 | 174篇 |
2016年 | 236篇 |
2015年 | 235篇 |
2014年 | 289篇 |
2013年 | 343篇 |
2012年 | 551篇 |
2011年 | 599篇 |
2010年 | 375篇 |
2009年 | 327篇 |
2008年 | 554篇 |
2007年 | 611篇 |
2006年 | 608篇 |
2005年 | 597篇 |
2004年 | 624篇 |
2003年 | 561篇 |
2002年 | 531篇 |
2001年 | 78篇 |
2000年 | 70篇 |
1999年 | 93篇 |
1998年 | 115篇 |
1997年 | 93篇 |
1996年 | 94篇 |
1995年 | 76篇 |
1994年 | 74篇 |
1993年 | 61篇 |
1992年 | 59篇 |
1991年 | 41篇 |
1990年 | 49篇 |
1989年 | 30篇 |
1988年 | 32篇 |
1987年 | 25篇 |
1986年 | 21篇 |
1985年 | 18篇 |
1984年 | 20篇 |
1983年 | 12篇 |
1982年 | 15篇 |
1981年 | 12篇 |
1980年 | 12篇 |
1979年 | 6篇 |
1978年 | 14篇 |
1977年 | 4篇 |
1976年 | 5篇 |
1971年 | 4篇 |
排序方式: 共有9274条查询结果,搜索用时 35 毫秒
21.
Takashi Ito Ryuji Sakakibara MD Tatsuya Yamamoto Tomoyuki Uchiyama Zhi Liu Masato Asahina Morihiro Higashi Kimihito Arai Shoichi Ito Yusuke Awa Kaori Yamamoto Mika Kinou Tomonori Yamanishi Takamichi Hattori 《Clinical autonomic research》2006,16(1):66-71
Abstract Uro-neurological assessment was performed in four patients with small-fiber neuropathy due to amyloidosis (2 transthyretin-type/2
immunoglobulin light-chain-type). Voiding difficulties were due to detrusor weakness and impaired bladder sensation. In two
patients cholinesterase inhibition treatment caused urge incontinence, indicating detrusor denervation supersensitivity. The
underlying mechanisms of urinary dysfunction seem to involve postganglionic cholinergic and afferent somatic nerves. 相似文献
22.
Yoshihide Nagasako Meang Bong Jin Hiroshi Miyazaki Masato Nakayama Tsuyoshi Shimamura Hiroyuki Furukawa Michiaki Matushita Satoru Todo 《Liver transplantation》2006,12(3):435-439
Thrombocytopenia is a frequent finding following living donor hepatectomy. It appears more pronounced in right graft donors than in left graft donors. This study analyzed postoperative thrombocytopenia in 20 living liver donors and examined the change of endogenous thrombopoietin (TPO) in its recovery. Platelet count, TPO level, fibrinogen degradation product (FDP), and D-Dimer were measured before surgery and on postoperative days (PODs) 1, 2, 3, 5, 7, and 14. Concurrently, liver and spleen volumes were calculated by computed tomography. Platelet count on POD 3 was significantly lower in right graft donors than in left graft donors (13.0 +/- 3.7 x 10(4)/microL vs. 16.8 +/- 4.0 x 10(4)/microL, P = 0.039) but recovered by POD 7 in all donors. Postoperative elevations of FDP and D-Dimer were significantly higher in right graft donors than in left graft donors. TPO level rose immediately after surgery, peaked on POD 5 in left graft donors and on POD 7 in right graft donors, and fell nearly to preoperative levels by POD 14. Postoperative TPO level per liver volume was significantly higher in right graft donors than in left graft donors. In conclusion, thrombocytopenia following living donor hepatectomy resolved within the first week regardless of graft type and was mainly associated with increasing consumption of circulating platelets, possibly due to intrahepatic and splenic congestion. With a reduced number of circulating platelets, TPO level rapidly increases. Also, with reduced consumption of platelets related to recovery from surgery, thrombocytopenia should resolve. As a consequence, TPO level would be expected to fall. 相似文献
23.
ABSTRACT Embryotoxicity and teratogenicity of cadmium (Cd) and modulation of its effects by N-acetyl-L-cysteine (NAC) were evaluated in mice. Pregnant ICR mice were intraperitoneally injected with 3.5 mg/kg of CdCl2 on day 10 or 11 of gestation (vaginal plug = day 0). Pregnant mice were pretreated with 160 mg/kg of NAC intravenously 2 hours before dosing with CdCl2 . Pregnant mice were killed on day 17 of gestation. Fetuses were examined for external malformations, especially limb malformations, cleft palate and abnormal palatal rugae. There was little difference in body weight gain of dams during the gestation period in the groups treated with NAC plus Cd as compared with the groups treated with Cd alone. Pretreatment with 160 mg/kg of NAC decreased the fetal mortality, incidence of cleft palate and abnormal palatal rugae induced by Cd on day 11. On day 10, pretreatment with NAC decreased the incidence of Cd induced abnormal palatal rugae. These results clearly indicate that NAC exerts protective effects against embryotoxicity and teratogenicity of Cd. 相似文献
24.
Yoichi Kikuchi Taku Sakurada Masato Suzuki Tomoyasu Hirano Katsuyuki Kusajima 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(8):375-378
Off-pump coronary artery bypass grafting has become an attractive surgical alternative for myocar-dial revascularization because
of the advantage of myocardial protection and other benefits of patients. However, it is still regarded as a controversial
treatment for the coronary artery disease accompanied by atrial fibrillation (AF). A significant number of patients in need
of coronary revascularization have chronic AF. Although the Cox-Maze III procedure is the gold standard for the surgical treatment
of AF, few of these patients undergo AF operations at the time of their coronary bypass grafting. We report herein a case
of the pulmonary vein isolation to eliminate the AF by means of epicardial radiofrequency ablation combined with 2 vessels
coronary artery bypass grafting on the beating heart with the aid of cardiopulmonary bypass. 相似文献
25.
26.
27.
Masato Nakajima Koji Tsuchiya Yoshihiro Honda Hiroshi Koshiyama Tatsuho Kobayashi 《General thoracic and cardiovascular surgery》2009,57(12):654-656
Although the causes of stroke are diverse, thromboembolism due to a mobile aortic thrombus is rare. We describe a surgical
case of acute massive pulmonary embolism after critical cerebral infarction associated with a mobile ascending aortic thrombus
in a 52-year-old woman. Concomitant surgical removal of the aortic thrombus and pulmonary embolectomy was performed successfully,
and the patient has been stable without recurrent thromboembolic complications after 18 months of follow-up. 相似文献
28.
Kohsuke Sasaki Daniel Pinkel Masato Tsukahara Ichiro Murano Joe W Gray 《Pathology international》1994,44(2):145-150
A human chromosomal translocation t(8;9) was detected using two-color fluorescence in situ hybridization with probes capable of staining the entire lengths of each of these chromosomes. The chromosome 8 probe was labeled with biotin and detected with Texas red, while the chromosome 9 probe was labeled with AAF and detected with FITC . In normal metaphase spreads, two metaphases from the proband, two red, one green and one part red and part green derivative chromosome were seen. The bicolor chromosome corresponded to translocation of a chromosome 8 segment to the distal part of the q region of one chromosome 9, as originally indicated by banding analysis. In interphase nuclei of the proband, four domains with bright fluorescence were recognized in many nuclei. Two were red, one was green, and the fourth had portions of both colors, indicating the presence of the translocation. 相似文献
29.
Regulation of phospholipase A2 in human leukemia cell lines: its implication for intracellular signaling. 总被引:2,自引:1,他引:1 下载免费PDF全文
Y Tsujishita Y Asaoka Y Nishizuka 《Proceedings of the National Academy of Sciences of the United States of America》1994,91(14):6274-6278
Permeabilized human leukemia HL-60 and U-937 cells suspended in an acidic or alkaline medium release various unsaturated fatty acids, most abundantly oleic and arachidonic acids. Concomitant production of lysophospholipids suggests that phospholipases A2 play a major role in this fatty acid release reaction. The fatty acid release at acidic conditions depends on the intracellular Ca2+ concentrations at the 10(-8)-10(-7) M range and is enhanced by membrane-permeant diacylglycerols, although this enhancement seems independent of protein kinase C activation. On the other hand, the fatty acid release at alkaline conditions is potentiated by vanadate, and this potentiation is counteracted by genistein, suggesting a role of tyrosine phosphorylation in this release reaction. GTP[gamma S], an activator of G proteins, greatly enhances the fatty acid release. Aluminum fluoride, another activator of heterotrimeric G proteins, also greatly potentiates this release reaction. Phorbol ester increases the fatty acid release at alkaline conditions, to some extent, whereas it counteracts the vanadate-induced potentiation of fatty acid release. The results imply that several phospholipases A2 are coupled to receptors for their activation, thereby functioning in the transmembrane control of cellular events. 相似文献
30.
We report an 18-year-old boy with occipital horn syndrome and we review the 20 cases previously published with this syndrome. The distinctive features common to all patients were unusual facial appearance, skeletal abnormalities, chronic diarrhea and genitourinary abnormalities. The skeletal abnormalities included occipital horns, short, broad clavicles, deformed radii, ulnae, and humeri, narrowing of the rib cage, undercalci-fied long bones with thin cortical walls and coxa valga. Occipital horn syndrome is inherited in an X-linked recessive fashion. Our analysis indicates that occipital horn syndrome is associated with a recognizable characteristic phenotype. 相似文献