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101.
102.
Wada Takehiko Ishimoto Takuji Nakaya Izaya Kawaguchi Takehiko Sofue Tadashi Shimizu Sayaka Kurita Noriaki Sasaki Sho Nishiwaki Hiroki Koizumi Masahiro Saito Shoji Nishibori Nobuhiro Oe Yuji Yoshida Mai Miyaoka Yoshitaka Akiyama Shin’ichi Itano Yuya Okazaki Masaki Ozeki Takaya Ichikawa Daisuke Oguchi Hideyo Kohsaka Satoshi Kosaka Shiho Kataoka Yuki Shima Hideaki Shirai Sayuri Sugiyama Kazuhiro Suzuki Tomo Son Daisuke Tanaka Tomomi Nango Eishu Niihata Kakuya Nishijima Yoko Nozu Kandai Hasegawa Midori Miyata Rei Yazawa Masahiko Yamamoto Yoshihiro Yamamoto Ryohei Shibagaki Yugo Furuichi Kengo Okada Hirokazu Narita Ichiei 《Clinical and experimental nephrology》2021,25(12):1277-1285
Clinical and Experimental Nephrology - 相似文献
103.
Miyake A Akagi T Enose Y Ueno M Kawamura M Horiuchi R Hiraishi K Adachi M Serizawa T Narayan O Akashi M Baba M Hayami M 《Journal of medical virology》2004,73(3):368-377
We have previously reported that concanavalin A-immobilized polystyrene nanospheres (Con A-NS) could efficiently capture HIV-1 particles and that intranasal immunization with inactivated HIV-1-capturing nanospheres (HIV-NS) induced vaginal anti-HIV-1 IgA antibody response in mice. In this study, to evaluate the protective effect of immunization, each three macaques was intranasally immunized with Con A-NS or inactivated simian/human immunodeficiency virus KU-2-capturing nanospheres (SHIV-NS) and then intravaginally challenged with a pathogenic virus, SHIV KU-2. After a series of six immunizations, vaginal anti-HIV-1 gp120 IgA and IgG antibodies were detected in all SHIV-NS-immunized macaques. After intravaginal challenge, one of the three macaques in each of the Con A-NS- and SHIV-NS-immunized groups was infected. Plasma viral RNA load of infected macaque in SHIV-NS-immunized macaques was substantially less than that in unimmunized control macaque and reached below the detectable level. However, it could not be determined whether intranasal immunization with SHIV-NS is effective in giving complete protection against intravaginal challenge. To explore the effect of the SHIV-NS vaccine, the remaining non-infected macaques were rechallenged intravenously with SHIV KU-2. After intravenous challenge, all macaques became infected. However, SHIV-NS-immunized macaques had lower viral RNA loads and higher CD4(+) T cell counts than unimmunized control macaques. Plasma anti-HIV-1 gp120 IgA and IgG antibodies were induced more rapidly in the SHIV-NS-immunized macaques than in the controls. The rapid antibody responses having neutralizing activity might contribute to the clearance of the challenge virus. Thus, SHIV-NS-immunized macaques exhibited partial protection to vaginal and systemic challenges with SHIV KU-2. 相似文献
104.
105.
106.
Ueda M Psarras K Jinno H Ikeda T Enomoto K Kitajima M Futami J Yamada H Seno M 《Breast cancer (Tokyo, Japan)》1997,4(4):253-255
Recombinant human ribonuclease 1 (RNasel) was chemically linked to recombinant human epidermal growth factor (EGF). The cytotoxicity
of this conjugate was assayed using MTT assay. The EGF-RNase conjugate showed dose-dependent cytotoxicity against breast and
squamous cell carcinomas overexpressing the EGF receptor (EGFR). The cytotoxicity of the conjugate correlated positively with
the level of EGFR expression by each cell line. These results suggest that the EGF-RNase conjugate is a more effective anticancer
agent with less immunogenicity and toxicity than conventional chimeric breast cancer toxins. 相似文献
107.
Imamura Hitoshi Maruyama Toru Okabe Hiroaki Shimada Hidekata Otagiri Masaki 《Pharmaceutical research》1994,11(4):566-570
We examined different fluorescent probes suitable for fluorometric determination of 1-acid glycoprotein (AGP) in serum. Quinaldine red (QR) was shown to bind strongly and selectively to AGP. Taking advantage of the enhanced fluorescence of QR in the presence of AGP, we developed a direct method for the determination of serum AGP without removal of other serum proteins such as albumin. AGP concentrations in serum of healthy volunteers and patients correlated well with results from the conventional single radial immunodiffusion (SRID) method (r = 0.93, slope = 1). The newly developed method is faster and has a larger analytical concentration range than the SRID method. This method can also be used to determine AGP in serum of experimental animals, and it can serve to monitor AGP serum concentrations for pharmacokinetic evaluation of basic drugs. 相似文献
108.
109.
Masaki H 《Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica》1999,59(14):844-852
A recent strategy in the treatment of pediatric cancer is the "total cell kill", in which the main part of therapy depends on intensive, aggressive chemotherapy with or without bone marrow transplantation. Radiotherapy, like surgery, plays a role in local treatment. Recent progress in therapy has permitted cures even of patients with advanced cancer. Disease-free patients should have the same quality of life as that of healthy children of the same sex and age. Therefore, both saving the patient's life and providing him or her with a good quality of life are important in treatment policy. To obtain these goals, radiation therapy has been included in combined multi-modality therapy for the management of pediatric cancer. Other important concerns are to reduce the radiation dose and determine the timing of radiation therapy. 相似文献
110.
Finger bougie method compared with pyloroplasty in the gastric replacement of the esophagus 总被引:2,自引:0,他引:2
Yamashita Y Hirai T Mukaida H Yoshimoto A Kuwahara M Inoue H Toge T 《Surgery today》1999,29(2):107-110
To elucidate the necessity of pyloroplasty for the gastric tube through the posterior mediastinum in esophageal surgery, gastric
emptying and duodenogastric reflux (DGR) were evaluated in 16 cases undergoing an anterior pylorectomy (group P) and in 16
cases treated by the finger bougie method (group F). First, the obstruction and reflux symptoms were examined based on a patient
questionnaire using a brief scoring system. The median value of the symptom score showed the patients in P to have more symptoms
than those in F; however, the difference was not significant (8.0 vs 6.0). Secondly, the swallowed Tc O4
− (85 MBq) was counted using a gamma camera at three sites on the sternal bone in the upright position based on a gastric transit
scintigram. Both the descending time of the RI peak and the clearance rates were similar between the two groups. Thirdly,
intragastric 24-h pH monitoring was carried out. Antimony pH sensors were anchored 5 and 15 cm below the esophagogastrostomy.
We could not find any difference between the two groups in both the % time pH>4 and %time pH>7. These findings thus revealed
no big difference between groups P and F. The finger bougie method to drain the vagotomized posterior mediastinal stomach
was found to achieve results similar to conventional pyloroplasty, while it was also simpler and safer. 相似文献