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91.
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease caused by the SFTS virus (SFTSV). SFTS is mainly prevalent in East Asia. It has a mortality rate of up to 30%, and there is no approved treatment against the disease. In this study, we evaluated the effect of loperamide, an antidiarrheal and antihyperalgesic agent, on the propagation of SFTSV in a cell culture system. Methods: SFTSV-infected human cell lines were exposed to loperamide, and viral titers were evaluated. To clarify the mode of action of loperamide, several chemical compounds having shared targets with loperamide were used. Calcium imaging was also performed to understand whether loperamide treatment affected calcium influx. Results: Loperamide inhibited SFTSV propagation in several cell lines. It inhibited SFTSV in the post-entry step and restricted calcium influx into the cell. Furthermore, nifedipine, a calcium channel inhibitor, also blocked post-entry step of SFTSV infection. Conclusions: Loperamide inhibits SFTSV propagation mainly by restraining calcium influx into the cytoplasm. This indicates that loperamide, a Food and Drug Administration (FDA)-approved drug, has the potential for being used as a treatment option against SFTS. 相似文献
92.
Matsuda Yasuhiro Masuda Masaharu Asai Mitsutoshi Iida Osamu Okamoto Shin Ishihara Takayuki Nanto Kiyonori Kanda Takashi Tsujimura Takuya Okuno Shota Hata Yosuke Uematsu Hiroyuki Mano Toshiaki 《Journal of interventional cardiac electrophysiology》2021,61(1):171-179
Journal of Interventional Cardiac Electrophysiology - Cardiac conduction disturbance necessitating pacemaker implantation is common among elderly patients. However, patients often have... 相似文献
93.
Yukio Oshiro Hiroshi Harada Kiyoshi Hasegawa Naotake Akutsu Tomoharu Yoshizumi Naoki Kawagishi Koji Nanmoku Naotsugu Ichimaru Kenichi Okamura Masahiro Ohira Yoshihiro Itabashi Nobuhiro Fujiyama Kentaro Ide Hideaki Okajima Kohei Ogawa Kosei Takagi Hidetoshi Eguchi Masahiro Shinoda Kiyotaka Nishida Jiro Shimazaki Mitsugi Shimoda Masaharu Takahashi Hiroaki Okamoto Shuji Suzuki 《Hepatology research》2021,51(5):538-547
94.
Dr. Manabu Yamamura M.D. Masaharu Nishi M.D. Haruo Furubayashi M.D. Koshiro Hioki M.D. Masakatsu Yamamoto M.D. 《Diseases of the colon and rectum》1985,28(5):347-352
A case of generalized peritonitis, secondary to a perforation of the rectosigmoid colon during barium-enema roentgenography,
is presented. The patient required immediate surgical intervention with the prime importance of the treatment being removal
of as much of the contaminating materials as possible. This was done successfully with irrigation and wiping, using urokinase
solution. Peritoneal lavage with urokinase solution was also carried out in the early postoperative period. Fluid replacement
with careful monitoring of fluid and electrolyte balance is essential before, during, and after the surgical procedure. Adequate
antibiotic therapy and careful respiratory and nutritional support are also important. 相似文献
95.
Yasuhiro Hamatani Moritake Iguchi Michikazu Nakamura Ryo Ohtani Yugo Yamashita Daisuke Takagi Takashi Unoki Mitsuru Ishii Nobutoyo Masunaga Hisashi Ogawa Mio Hamatani Mitsuru Abe Masaharu Akao 《Heart and vessels》2016,31(7):1154-1161
Heart failure (HF) increases the risk of ischemic stroke. Data regarding the incidence and predictors of ischemic stroke during hospitalization for HF are limited. The study population of this retrospective cohort study consisted of patients with congestive HF, consecutively admitted to our center from October 2010 to April 2014. We excluded patients complicated with acute myocardial infarction, infective endocarditis, and takotsubo cardiomyopathy. We also excluded those with dialysis or mechanical circulatory support. We investigated the incidence of ischemic stroke during hospitalization for HF. Thereafter, we divided the patients without oral anticoagulants at admission into two groups: patients with ischemic stroke and those without it, and explored the predictors of ischemic stroke. A total of 558 patients (287 without atrial fibrillation (AF), 271 with AF) were enrolled. The mean age was 76.8 ± 12.3 years, and 244 patients (44 %) were female. The mean left-ventricular ejection fraction was 47.4 %. Oral anticoagulants were prescribed in 147 patients (8 without AF, 139 with AF). During hospitalization (median length 18 days), symptomatic ischemic stroke (excluding catheter-related) occurred in 15 patients (2.7 % of the total, 8 without AF, 7 with AF). Predictors significantly associated with increased risk of ischemic stroke in patients without oral anticoagulants were as follows; short-term increases in blood urea nitrogen after admission (at day 3; odds ratio (per 1 md/dl): 1.06, 95 % confidence interval (CI) 1.01–1.11, p = 0.02, and at day 7; odds ratio: 1.03, 95 % CI 1.00–1.07, p = 0.03, respectively), and previous stroke (odds ratio; 3.33, 95 % CI 1.01–11.00, p = 0.04). The incidence of ischemic stroke during hospitalization for HF was high, even in patients without AF. Previous stroke and short-term increases in blood urea nitrogen was significantly associated with the incidence of ischemic stroke. 相似文献
96.
The tight junction of pancreatic exocrine cells is thought to regulate paracellular permeability, and is a possible reflux
route of pancreatic juice into the blood flow. Morphological changes in the tight junction of canine pancreatic acinar cells
following intraductal hypertension and secretin stimulation were morphometrically analyzed to obtain evidence of the control
of the paracellular reflux. Pancreatic tissues obtained from 25 dogs after intraductal hypertension, 3 dogs after secretin
stimulation, and 5 control dogs were studied. Intraductal pressure was either 20 cmH2O, 30 cmH2O, or 40 cmH2O. Freeze fracture
replicas of these pancreatic tissues were observed by electron microscopy. Tight junctions were classified into six morphometric
types. Reticular type, parallel type, and mixed type comprised the common types predominantly found in all groups, and three
special types were found, infrequently, only after intraductal hypertension. The percentages of the common types were significantly
different between the groups. The areas of the tight junctions, and other morphometric parameters, were significantly less
after 20 cmH2O intraductal hypertension and secretin stimulation than in the controls. However, these findings after 30 cmH2O
or 40 cmH2O intraductal hypertension did not differ from those in the controls. The areas of the three special types of tight
junctions were larger than those of the common types. These results suggest that the tight junction of pancreatic exocrine
cells is a morphologically dynamic structure that is altered by the extent of intraductal hypertension, and support the hypothesis
that paracellular permeability is the mechanism of the reflux of pancreatic juice.
Received: November 10, 1999 / Accepted: April 28, 2000 相似文献
97.
Myocardial perfusion and fatty acid metabolism in patients with tako-tsubo-like left ventricular dysfunction 总被引:10,自引:0,他引:10
Kurisu S Inoue I Kawagoe T Ishihara M Shimatani Y Nishioka K Umemura T Nakamura S Yoshida M Sato H 《Journal of the American College of Cardiology》2003,41(5):743-748
OBJECTIVES: We sought to assess myocardial perfusion and metabolism in patients with peculiar transient asynergy, which consisted of basal normokinesia and apical akinesia of the left ventricle (LV) at the same time. BACKGROUND: This asynergy has been widely called "tako-tsubo-like LV dysfunction" in Japan, but little is known about its pathophysiology. METHODS: We performed rest tallium-201 ((201)Tl) and iodine-123-beta-methyl-p-iodophenyl penta-decanoic acid ((123)I-BMIPP) dual-isotope myocardial single-photon emission computed tomography (SPECT) in 14 patients with tako-tsubo-like LV dysfunction. The LV was divided into 17 segments, and each segment was graded with scores between normal uptake (0) and defect (4). We also measured the Thrombolysis in Myocardial Infarction trial (TIMI) frame count in 28 patients and 20 control subjects. RESULTS: Early SPECT (5 +/- 3 days) revealed that the total defect score value with BMIPP was significantly higher than reduced uptake with (201)Tl (p < 0.01). Reduced uptake of BMIPP was observed in parallel with an apical akinetic region and usually involved uptake of (201)Tl. This discrepancy improved gradually during the follow-up period (29 +/- 6 days) (p = 0.36). Compared with control subjects, patients had a TIMI frame count that was significantly higher in all coronary arteries immediately after onset. This higher TIMI frame count decreased but was sustained even after resolution of tako-tsubo-like LV dysfunction. CONCLUSIONS: Our data suggest that myocardial fatty acid metabolism is more severely impaired than myocardial perfusion, in parallel with an apical akinetic region during the early phase, and that impaired multivessel coronary microcirculation is involved, at least in part, in tako-tsubo-like LV dysfunction. 相似文献
98.
Yoshikazu Yonel Iwao Kurose Dai Fukumura Hidetsugu Saito Soichiro Miura Nobuhiro Tsukada Masaya Oda Masaharu Tsuchiya 《Liver international》1994,14(1):37-44
Abstract: A co-culture study of purified rat Kupffer cells and human colon cancer cells was performed, and the process of the tumor cell injury was observed under an inverted type fluorescence microscope loaded with propidium iodide, and also under an electron microscope. Ultrastructurally there was direct membrane-to-membrane interaction between Kupffer cells and colon cancer cells in time. The interaction occurred 1 h after start of the co-culture, and injured tumor cells were observed closely attached to pseudopodia of Kupffer cells at 6 h. The number of propidium iodide-positive tumor cells with damage increased in time. Pretreatment with NG-monomethyl-L-arginine reduced the number of injured tumor cells without preventing morphological interactions, but superoxide dismutase did not prevent the tumoricidal effect. Pretreatment with trypsin completely inhibited cell interaction and damage to tumor cells. In conclusion, the morphological interaction of Kupffer cells as a first step and the involvement of nitric oxide-derived free radicals as a second step seem to play a significant role in the host-defense mechanism. 相似文献
99.
100.
Fumi Ohdaira Kazutoshi Nakamura Hideaki Nakayama Makoto Satoh Tetsuro Ohdaira Masami Nakamata Masaki Kohno Akira Iwashima Akira Onda Yoshiaki Kobayashi Katsuya Fujimori Toshio Kiguchi Shuji Izumi Tadaharu Kobayashi Hideo Shinoda Sugata Takahashi Fumitake Gejyo Masaharu Yamamoto 《Sleep & breathing》2007,11(2):93-101
Information on obstructive sleep apnea-hypopnea syndrome (OSAHS) in Japan has been limited. The purposes of this clinical study were to evaluate the demographic characteristics of Japanese OSAHS patients and to assess how demographic factors are associated with OSAHS severity. We analyzed 3,659 OSAHS patients who underwent polysomnographic evaluation between January 2000 and December 2004 at 11 hospitals in Niigata Prefecture, Japan. Data consisted of apnea-hypopnea index (AHI) and demographic characteristics, including sex, age, and body-mass index, for statistical analysis. Levels of obesity were classified according to the WHO criteria. The male-to-female patient ratio for OSAHS was 4.6, and male patients presented more severe OSAHS than female patients. High AHI and a high proportion of moderate to serious OSAHS (AHI > or = 15) were found among the patients in their 30s, as well as female patients in their 70s and male patients in their 80s. The AHI and the proportion of moderate-to-serious OSAHS (AHI > or = 15) were greater in patients classified as underweight than in normal weight patients. In conclusion, there is a higher male predominance in the prevalence of OSAHS, and in both sexes, the results suggest different pathophysiological mechanisms of deteriorating OSAHS between adults under age 55 and adults 55 years or over. In addition, underweight patients exhibit more severe OSAHS than normal weight patients. 相似文献