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81.
Masaho Ota Yoko Murata Hiroko Ide Reiki Eguchi Tsutomu Nakumura Kazuhiko Hayashi Kousuke Narumiya Itaru Oi Ken Takasaki 《Digestive endoscopy》2005,17(1):59-63
Objective: The aim of the present study was to assess the usefulness of endoscopic ultrasonography (EUS) for evaluating the efficacy of neoadjuvant therapy for advanced esophageal carcinoma based on the Response Evaluation Criteria in Solid Tumors (RECIST). Patients and Methods: Sixty‐two patients with advanced esophageal carcinoma underwent surgical resection after neoadjuvant therapy. The maximal tumor thickness was measured by EUS before and after neoadjuvant therapy, and the percent reduction was compared with the pathological response. Based on the RECIST, PD‐SD (progressive disease‐stable disease) was defined as < 30% reduction of tumor thickness on EUS, PR (partial response) as ≥ 30% reduction of tumor thickness, and CR (complete response) as no detectable tumor (100%). Results: The percent reduction of the thickness of Grade 0–1, Grade 2 and Grade 3 tumor was 11.5 ± 21.0%, 48.2 ± 17.0% and 74.9 ± 21.1%, respectively. There were significant differences in the extent of reduction among the three groups. Based on the RECIST, 80% of Grade 0–1 cases, 91% of Grade 2 cases and 22% of Grade 3 cases were PD‐SD, PR, and CR according to EUS, respectively. EUS correctly identified 80% of non‐responders and 94% of responders. Conclusions: The percentage reduction of tumor thickness on EUS closely reflected the pathological evaluation. EUS evaluation based on the RECIST seems to be useful for monitoring neoadjuvant therapy in patients with esophageal carcinoma. 相似文献
82.
83.
Takayuki Ogura Alan Kawarai Lefor Mitsunobu Nakamura Kenji Fujizuka Kousuke Shiroto Minoru Nakano 《The Journal of emergency medicine》2017,52(5):715-722
Background
In trauma resuscitation with resuscitative endovascular balloon occlusion of the aorta (REBOA), urgent and accurate placement of the catheter in the resuscitation area without fluoroscopy can shorten the time from admission to REBOA, allowing rapid, temporary control of bleeding.Discussion
The experience-based protocol in our center for ultrasound-guided REBOA in the resuscitation area without fluoroscopy is as follows: the femoral artery is punctured and a guidewire inserted; sonography is used to verify that the guidewire is in the abdominal aorta; the position of the balloon is confirmed with ultrasound after estimating the distance to the clavicle, and the pressure in the radial artery and sheath is used to monitor correct positioning; connect the pressure transducer to the catheter sheath for continuous monitoring of the blood pressure in the sheath, and inflate the balloon until the blood pressure tracing at the sheath has disappeared; check the pulse in the left radial artery, and withdraw the catheter slightly if the pulse in the radial artery is not palpable or is decreased (if this pulse is not palpable or decreased, the balloon is in the aortic arch). In this retrospective review of our REBOA protocol, between April 2012 and March 2016, 34 patients were enrolled. Two patients had complications, including dissection of the femoral artery in one and difficult percutaneous vascular access in another. Median time needed to complete the procedure was 8 min. Overall, 24 of 34 patients survived more than 24 h (72%), and overall mortality was 47%. Patients who lived more than 24 h, and then died had severe traumatic brain injury or septic shock.Conclusions
Ultrasound-guided REBOA is presented. Monitoring the blood pressure in the left radial artery allows us to determine adequate positioning of the balloon, and the blood pressure in the catheter sheath located in the femoral artery should also be monitored to prevent aortic injuries caused by the overinflation of the balloon. 相似文献84.
Yuji Yoshida Atsushi Ogata Sujin Kang Kousuke Ebina Kenrin Shi Satoshi Nojima Tetsuya Kimura Daisuke Ito Keiko Morimoto Masayuki Nishide Takashi Hosokawa Toru Hirano Yoshihito Shima Masashi Narazaki Hideki Tsuboi Yukihiko Saeki Tetsuya Tomita Toshio Tanaka Atsushi Kumanogoh 《Arthritis \u0026amp; Rheumatology》2015,67(6):1481-1490
85.
Suppressive effects of the NADPH oxidase inhibitor apocynin on intestinal tumorigenesis in obese KK‐Ay and Apc mutant Min mice
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86.
87.
Atsuchi N Nishida T Marutsuka K Asada Y Kamikubo Y Takeshita A Ueno H 《Circulation》2001,103(4):570-575
88.
Arita H Kishima H Hosomi K Iwaisako K Hashimoto N Saitoh Y Yoshimine T 《British journal of neurosurgery》2012,26(2):281-283
Hemifacial spasms (HFS) are usually caused by vascular compression on the extra-axial facial nerve. In this case, we concluded that an intra-axial brainstem cavernous angioma with a venous angioma diagnosed by MRI must have been responsible for HFS, because no other possible causes were found during intraoperative observations. 相似文献
89.
Kousuke Hanada Mieko Higuchi-Takeuchi Masanori Okamoto Takeshi Yoshizumi Minami Shimizu Kentaro Nakaminami Ranko Nishi Chihiro Ohashi Kei Iida Maho Tanaka Yoko Horii Mika Kawashima Keiko Matsui Tetsuro Toyoda Kazuo Shinozaki Motoaki Seki Minami Matsui 《Proceedings of the National Academy of Sciences of the United States of America》2013,110(6):2395-2400
It is likely that many small ORFs (sORFs; 30–100 amino acids) are missed when genomes are annotated. To overcome this limitation, we identified ∼8,000 sORFs with high coding potential in intergenic regions of the Arabidopsis thaliana genome. However, the question remains as to whether these coding sORFs play functional roles. Using a designed array, we generated an expression atlas for 16 organs and 17 environmental conditions among 7,901 identified coding sORFs. A total of 2,099 coding sORFs were highly expressed under at least one experimental condition, and 571 were significantly conserved in other land plants. A total of 473 coding sORFs were overexpressed; ∼10% (49/473) induced visible phenotypic effects, a proportion that is approximately seven times higher than that of randomly chosen known genes. These results indicate that many coding sORFs hidden in plant genomes are associated with morphogenesis. We believe that the expression atlas will contribute to further study of the roles of sORFs in plants. 相似文献
90.
Katsumichi Takeda Kousuke Nakata Shinji Takahashi Toshiyuki Chikuma Takeshi Kato 《Brain research》1998,779(1-2)
After treatment with pentylenetetrazol (PTZ), cholecystokinin (CCK) mRNA and CCK-like immunoreactivity (CCK-LI) levels were determined in rat hippocampus and cortex at different time points. In the temporal cortex treatment with 60 mg/kg PTZ, i.p., induced increases of CCK mRNA and CCK-LI levels at 2 days after the injection. In the hippocampus, a similar increase of CCK mRNA level was observed on the second day. By contrast, in the frontal cortex, CCK-LI level was increased at 10 days after the treatment with PTZ. These data show that PTZ increases both CCK mRNA and CCK-LI levels in these rat brain regions at different time. 相似文献