全文获取类型
收费全文 | 263431篇 |
免费 | 38540篇 |
国内免费 | 3083篇 |
专业分类
耳鼻咽喉 | 6233篇 |
儿科学 | 9090篇 |
妇产科学 | 5084篇 |
基础医学 | 20018篇 |
口腔科学 | 5517篇 |
临床医学 | 36791篇 |
内科学 | 72761篇 |
皮肤病学 | 10185篇 |
神经病学 | 25785篇 |
特种医学 | 8946篇 |
外国民族医学 | 1篇 |
外科学 | 50750篇 |
综合类 | 656篇 |
现状与发展 | 72篇 |
一般理论 | 55篇 |
预防医学 | 18363篇 |
眼科学 | 5231篇 |
药学 | 9264篇 |
中国医学 | 456篇 |
肿瘤学 | 19796篇 |
出版年
2024年 | 596篇 |
2023年 | 5701篇 |
2022年 | 3237篇 |
2021年 | 7301篇 |
2020年 | 8384篇 |
2019年 | 5616篇 |
2018年 | 11171篇 |
2017年 | 10052篇 |
2016年 | 11621篇 |
2015年 | 11997篇 |
2014年 | 20195篇 |
2013年 | 21922篇 |
2012年 | 15256篇 |
2011年 | 15582篇 |
2010年 | 15743篇 |
2009年 | 18628篇 |
2008年 | 13690篇 |
2007年 | 11969篇 |
2006年 | 13724篇 |
2005年 | 10541篇 |
2004年 | 9066篇 |
2003年 | 7376篇 |
2002年 | 6916篇 |
2001年 | 4320篇 |
2000年 | 3366篇 |
1999年 | 3802篇 |
1998年 | 4456篇 |
1997年 | 4125篇 |
1996年 | 3888篇 |
1995年 | 3660篇 |
1994年 | 2370篇 |
1993年 | 1916篇 |
1992年 | 1659篇 |
1991年 | 1595篇 |
1990年 | 1248篇 |
1989年 | 1347篇 |
1988年 | 1176篇 |
1987年 | 986篇 |
1986年 | 1039篇 |
1985年 | 825篇 |
1984年 | 676篇 |
1983年 | 656篇 |
1982年 | 669篇 |
1981年 | 517篇 |
1980年 | 489篇 |
1979年 | 382篇 |
1978年 | 405篇 |
1977年 | 475篇 |
1975年 | 325篇 |
1972年 | 332篇 |
排序方式: 共有10000条查询结果,搜索用时 671 毫秒
991.
992.
993.
Ennio Del Giudice Maria Cristina Bianchi Michela Tosetti Andrea Varrone Alfonso Romano Angela Francesca Crisanti Luigi Titomanlio Floriana Imperati 《Epileptic Disord》2006,8(4):289-293
Patients with Taylor-type focal cortical dysplasia (TTFCD) generally present with medically intractable epilepsy and impaired neurological and/or intellectual functioning. Surgery usually proves to be the only treatment approach leading to control of seizures. We describe a 17-year-old girl with TTFCD who exhibited a very long period of seizure remission. Combined clinical and neuroimaging findings were compatible with a diagnosis of a balloon cell-subtype TTFCD. As for the clinical course, partial motor seizures began at one year of age and ceased at five: our patient has had no seizure recurrence over a 12-year-follow-up. Moreover, throughout the 15-year follow-up, neurological examinations and cognitive abilities always remained within normal limits. Neuropsychological assessment clearly showed no impairments in executive functions: planning abilities, working memory, attention and impulse control, or constructive aspects of motor coordination. The predominant deficits pertained to verbal abilities in the context of borderline intellectual performances. To our knowledge, this case report documents the longest duration of seizure remission in a patient with TTFCD, thus emphasizing the possible benign course of such dysplastic lesions which usually have a poor prognosis, leading to early surgical treatment. 相似文献
994.
995.
Placenta can be considered as a pump of calcium necessary for the normal development of the fetus. We believe that the location of this pump is in the placental basement membrane. The calcification of this membrane has been described only in cases of in utero fetal death. In this study we describe for the first time a case of placental calcification in a living fetus. The fetus of a normal 21-year-old pregnant woman showed heart abnormalities but the genetic analysis showed a normal male karyotype. The histology of the placenta demonstrated multiple intravillous linear and granular calcific incrustations The hemtoxylin/eosin stain of the sections revealed basement membrane calcific incrustations and intravillous calcium deposits. We postulate that the fetal circulation in the villi was impaired and the calcium that reached the villi from the mother was deposited at this level. 相似文献
996.
997.
Leo Sher Juan J Carballo Michael F Grunebaum Ainsley K Burke Gil Zalsman Yung-yu Huang J John Mann Maria A Oquendo 《Bipolar disorders》2006,8(5P2):543-550
Objectives: Bipolar disorder is a severe illness that is associated with suicidal behavior. A biological predictor of highly lethal suicide attempts in patients with bipolar disorder would be valuable. We hypothesized that cerebrospinal fluid (CSF) monoamine metabolite levels are related to lethality of suicide attempts in bipolar patients and examined the relation between CSF 5-hydroxyindolacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) levels and maximum lethality of suicide attempts at baseline and during a 2-year follow up.
Methods: Twenty-seven bipolar depressed patients participated in the study. Demographic and clinical parameters were examined and recorded. Lumbar punctures were performed and CSF 5-HIAA, HVA, and MHPG were assayed by high-performance liquid chromatography with electrochemical detection. Following discharge, patients were evaluated after 3 months, 1 year, and 2 years. Each follow-up interview included an in-depth assessment of suicidal behavior during the intervening time period.
Results: Six subjects made suicide attempts during the 2-year follow-up. Bipolar patients who attempted suicide during the follow-up period had higher aggression and hostility scale scores compared to bipolar subjects who did not make a suicide attempt during the follow-up period. CSF 5-HIAA, HVA, and MHPG levels were negatively correlated with the maximum lethality of suicide attempts during the 2-year follow-up period.
Conclusions: Our finding is the first observation that CSF monoamine metabolite levels may be predictors of lethality of suicide attempts in patients with bipolar disorder. Further studies are necessary to answer the question whether CSF monoamine metabolite levels are clinically useful biochemical predictors of highly lethal suicide attempts or completed suicides. 相似文献
Methods: Twenty-seven bipolar depressed patients participated in the study. Demographic and clinical parameters were examined and recorded. Lumbar punctures were performed and CSF 5-HIAA, HVA, and MHPG were assayed by high-performance liquid chromatography with electrochemical detection. Following discharge, patients were evaluated after 3 months, 1 year, and 2 years. Each follow-up interview included an in-depth assessment of suicidal behavior during the intervening time period.
Results: Six subjects made suicide attempts during the 2-year follow-up. Bipolar patients who attempted suicide during the follow-up period had higher aggression and hostility scale scores compared to bipolar subjects who did not make a suicide attempt during the follow-up period. CSF 5-HIAA, HVA, and MHPG levels were negatively correlated with the maximum lethality of suicide attempts during the 2-year follow-up period.
Conclusions: Our finding is the first observation that CSF monoamine metabolite levels may be predictors of lethality of suicide attempts in patients with bipolar disorder. Further studies are necessary to answer the question whether CSF monoamine metabolite levels are clinically useful biochemical predictors of highly lethal suicide attempts or completed suicides. 相似文献
998.
999.
1000.
B. Shen MD Z. Younossi MD B. Dolmatch MD J. Newman MD M. Henderson MD J. Ong MD T. Gramlich MD M. Yamani MD 《The American journal of gastroenterology》2000,95(9):2607-2607