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101.
102.
Ewa Pakowska Agnieszka Szypowska Maria Lipka Monika Szpotaska Marlena Bazik Lidia Groele 《Pediatric diabetes》2009,10(5):298-303
Background: An insulin pump is an advanced technology offering new options of bolus – normal (N), dual wave (D-W) or square wave (S-W) bolus to deliver mealtime insulin.
Objectives: To assess the impact of D-W/S-W boluses on metabolic control (glycated haemoglobin A1c, HbA1c) and to estimate the paediatric patients compliance with implementation of this system in daily practice.
Methods: The cross-sectional study included 499 records of patients aged 0–18 yr. Data from the insulin pump memory provided information on the number of D-W/S-W boluses during a 2-wk period, the insulin requirement (U/kg/d) and the percentage of basal insulin. The HbA1c value (%) and the patient's weight were determined during medical examinations. Mealtime dose of insulin in D-W/S-W bolus was calculated based on the amount of carbohydrate and fat/protein products.
Results: The number of applied D-W/S-W boluses was 16.6 ± 0.77/14 d (ranged 0–95), while 18.8% of patients did not program D-W/S-W boluses. The lowest HbA1c value was found in the group using two and/or more D-W/S-W boluses per day (p = 0.001) compared with the group administrating less than one D-W/S-W bolus/d. Patients with HbA1c level <7.5% had a statistically higher relevant number of D-W/S-W boluses, 19.55 (95% CI: 17.44–21.65) vs. 12.42 (95% CI: 10.22–14.61) (p < 0.001), while there was no correlation between the number of boluses and HbA1c in patients in the remission phase (<0.5 IU/kg/d) (r = 0.012, p = 0.930).
Conclusions: Patients using at least one D-W/S-W bolus per day achieved a recommended level of HbA1c. Paediatric patients with type 1 diabetes mellitus were found to be able to apply D-W/S-W boluses in daily self-treatment process based on food counting. 相似文献
Objectives: To assess the impact of D-W/S-W boluses on metabolic control (glycated haemoglobin A1c, HbA1c) and to estimate the paediatric patients compliance with implementation of this system in daily practice.
Methods: The cross-sectional study included 499 records of patients aged 0–18 yr. Data from the insulin pump memory provided information on the number of D-W/S-W boluses during a 2-wk period, the insulin requirement (U/kg/d) and the percentage of basal insulin. The HbA1c value (%) and the patient's weight were determined during medical examinations. Mealtime dose of insulin in D-W/S-W bolus was calculated based on the amount of carbohydrate and fat/protein products.
Results: The number of applied D-W/S-W boluses was 16.6 ± 0.77/14 d (ranged 0–95), while 18.8% of patients did not program D-W/S-W boluses. The lowest HbA1c value was found in the group using two and/or more D-W/S-W boluses per day (p = 0.001) compared with the group administrating less than one D-W/S-W bolus/d. Patients with HbA1c level <7.5% had a statistically higher relevant number of D-W/S-W boluses, 19.55 (95% CI: 17.44–21.65) vs. 12.42 (95% CI: 10.22–14.61) (p < 0.001), while there was no correlation between the number of boluses and HbA1c in patients in the remission phase (<0.5 IU/kg/d) (r = 0.012, p = 0.930).
Conclusions: Patients using at least one D-W/S-W bolus per day achieved a recommended level of HbA1c. Paediatric patients with type 1 diabetes mellitus were found to be able to apply D-W/S-W boluses in daily self-treatment process based on food counting. 相似文献
103.
104.
The combination between transformations in adolescence, the indefiniteness they are accompanied by and the visual impairment justifies a study about the sexual experience of female, visually impaired adolescents included in society and in the school community. Five adolescents were interviewed at a Pedagogical Support Center. Questions attempted to find out their knowledge and understanding about the cause of their visual impairment, family composition and orientations, affective-sexual experience, level of knowledge about sexuality-related issues, including contraceptive methods and sexually transmitted diseases. Results revealed that these adolescents display the same sexuality development characteristics of their age group, though they have particular characteristics. It was observed there is a lack of knowledge regarding contraceptive methods and sexually transmitted diseases, of which the adolescents have superficial information. Making knowledge on the referred issues accessible to this population is indispensible. 相似文献
105.
106.
107.
Fejzo MS Ingles SA Wilson M Wang W MacGibbon K Romero R Goodwin TM 《European journal of obstetrics, gynecology, and reproductive biology》2008,141(1):13-17
Objective
The goal of this study was to determine the prevalence of severe nausea and vomiting of pregnancy/hyperemesis gravidarum among relatives of affected individuals.Study design
Family history data were obtained on 1224 self-reported cases of hyperemesis gravidarum. Cases completed an online survey administered by the Hyperemesis Education and Research Foundation between 2003 and 2006.Results
Approximately 28% of cases reported their mother had severe nausea and vomiting or hyperemesis gravidarum while pregnant with them. Of the 721 sisters with a pregnancy history, 137 (19%) had hyperemesis gravidarum. Among the most severe cases, those requiring total parenteral nutrition or nasogastric feeding tube, the proportion of affected sisters was even higher, 49/198 (25%). Nine percent of cases reported having at least two affected relatives including sister(s), mother, grandmother, daughters, aunt(s), and cousin(s).Conclusion
There is a high prevalence of severe nausea and vomiting of pregnancy/hyperemesis gravidarum among relatives of hyperemesis gravidarum cases in this study population. Because the incidence of hyperemesis gravidarum is most commonly reported to be 0.5%, this study provides strong but preliminary evidence for a genetic component to extreme nausea and vomiting of pregnancy. 相似文献108.
109.
Lara Schlaffke Robert Rehmann Marlena Rohm Louise A.M. Otto Alberto de Luca Jedrzej Burakiewicz Celine Baligand Jithsa Monte Chiel den Harder Melissa T. Hooijmans Aart Nederveen Sarah Schlaeger Dominik Weidlich Dimitrios C. Karampinos Anders Stouge Michael Vaeggemose Maria Grazia D'Angelo Filippo Arrigoni Hermien E. Kan Martijn Froeling 《NMR in biomedicine》2019,32(9)
The purpose of this study was to evaluate temporal stability, multi‐center reproducibility and the influence of covariates on a multimodal MR protocol for quantitative muscle imaging and to facilitate its use as a standardized protocol for evaluation of pathology in skeletal muscle. Quantitative T2, quantitative diffusion and four‐point Dixon acquisitions of the calf muscles of both legs were repeated within one hour. Sixty‐five healthy volunteers (31 females) were included in one of eight 3‐T MR systems. Five traveling subjects were examined in six MR scanners. Average values over all slices of water‐T2 relaxation time, proton density fat fraction (PDFF) and diffusion metrics were determined for seven muscles. Temporal stability was tested with repeated measured ANOVA and two‐way random intraclass correlation coefficient (ICC). Multi‐center reproducibility of traveling volunteers was assessed by a two‐way mixed ICC. The factors age, body mass index, gender and muscle were tested for covariance. ICCs of temporal stability were between 0.963 and 0.999 for all parameters. Water‐T2 relaxation decreased significantly (P < 10?3) within one hour by ~ 1 ms. Multi‐center reproducibility showed ICCs within 0.879–0.917 with the lowest ICC for mean diffusivity. Different muscles showed the highest covariance, explaining 20–40% of variance for observed parameters. Standardized acquisition and processing of quantitative muscle MRI data resulted in high comparability among centers. The imaging protocol exhibited high temporal stability over one hour except for water T2 relaxation times. These results show that data pooling is feasible and enables assembling data from patients with neuromuscular diseases, paving the way towards larger studies of rare muscle disorders. 相似文献
110.
J. W. Guzek Marlena Juszczak 《Journal of neural transmission (Vienna, Austria : 1996)》1985,62(1-2):125-136
Summary Pinealectomized, sham-operated and non operated control rats were injected intracerebroventricularly (i.c.v.) with a single dose of desmethylimipramine hydrochloride (DMI; 20g, dissolved in 10l of normal saline); after 4 hours they were decapitated and the hypothalamic and neurohypophysial oxytocin content was bioassayed using the milk-ejection effectin vitro.DMI decreased oxytocin content of the hypothalamus and neurointermediate lobe in non operated and sham-operated animals. In pinealectomized rats the oxytocin content of the hypothalamus and neurointermediate lobe diminished and could be further reduced by an i.c.v. DMI injection. As shown in animals pretreated with phenoxybenzamine, these events might be only partially related to an increase of alpha-adrenergic transmission.Conducted under contract No 10.4.04.9 with the Polish Academy of Sciences.- Submitted for poster presentation at the XXIX. Congress of the International Union of Physiological Sciences, Sydney, 28. August–3. September 1983 (abstract number 287.16). - A preliminary report, covering a part of the present findings, was published in Acta Physiologica Polonica34, 41–46 (1983). 相似文献