全文获取类型
收费全文 | 2208篇 |
免费 | 132篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 12篇 |
妇产科学 | 48篇 |
基础医学 | 330篇 |
口腔科学 | 40篇 |
临床医学 | 211篇 |
内科学 | 485篇 |
皮肤病学 | 84篇 |
神经病学 | 193篇 |
特种医学 | 189篇 |
外科学 | 407篇 |
综合类 | 15篇 |
预防医学 | 95篇 |
眼科学 | 45篇 |
药学 | 86篇 |
中国医学 | 3篇 |
肿瘤学 | 106篇 |
出版年
2023年 | 25篇 |
2022年 | 68篇 |
2021年 | 107篇 |
2020年 | 49篇 |
2019年 | 72篇 |
2018年 | 93篇 |
2017年 | 58篇 |
2016年 | 78篇 |
2015年 | 75篇 |
2014年 | 73篇 |
2013年 | 113篇 |
2012年 | 163篇 |
2011年 | 165篇 |
2010年 | 109篇 |
2009年 | 84篇 |
2008年 | 138篇 |
2007年 | 132篇 |
2006年 | 141篇 |
2005年 | 151篇 |
2004年 | 108篇 |
2003年 | 78篇 |
2002年 | 74篇 |
2001年 | 33篇 |
2000年 | 11篇 |
1999年 | 18篇 |
1998年 | 10篇 |
1997年 | 10篇 |
1996年 | 10篇 |
1995年 | 9篇 |
1994年 | 5篇 |
1993年 | 3篇 |
1991年 | 2篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1988年 | 3篇 |
1987年 | 7篇 |
1986年 | 9篇 |
1985年 | 4篇 |
1984年 | 4篇 |
1983年 | 9篇 |
1982年 | 2篇 |
1981年 | 5篇 |
1980年 | 2篇 |
1978年 | 3篇 |
1976年 | 5篇 |
1975年 | 2篇 |
1973年 | 2篇 |
1972年 | 5篇 |
1966年 | 2篇 |
1923年 | 1篇 |
排序方式: 共有2353条查询结果,搜索用时 15 毫秒
991.
992.
993.
Verhoeven MO van der Mooren MJ van de Weijer PH Verdegem PJ van der Burgt LM Kenemans P;CuraTrial Research Group 《Menopause (New York, N.Y.)》2005,12(4):412-420
OBJECTIVE: To investigate the effects of a novel dietary supplement containing soy isoflavones and Actaea racemosa Linnaeus (formerly called Cimicifuga racemosa L.) on climacteric symptoms in healthy perimenopausal women. DESIGN: In a multicenter, randomized, placebo-controlled, double-blind study, 124 women experiencing at least five vasomotor symptoms every 24 hours were randomized to receive daily either a phytoestrogen-containing supplement (n = 60) or placebo (n = 64) for 12 weeks. The modified Kupperman Index and Greene Climacteric Scale, a visual analogue scale designed to measure quality of life and the daily number and severity of hot flushes, was used in the screening period and in weeks 6 and 12. Changes in these scores from baseline were calculated. RESULTS: At weeks 6 and 12, all scores in both groups had improved compared with baseline, though the overall difference in scores between the groups was not statistically significant. CONCLUSION: The supplement containing soy isoflavones and A racemosa L. had no statistically significant effect on climacteric symptoms in perimenopausal women experiencing at least five vasomotor symptoms per day. 相似文献
994.
995.
Decay-accelerating factor regulates complement-mediated damage in the human atherosclerotic wall. 总被引:1,自引:0,他引:1
Decay-accelerating factor (DAF) is an intrinsic membrane inhibitor that regulates the activity of C3 and C5 convertases of the classical and alternative complement pathways. Using two monoclonal antibodies, IC6 and IA10, DAF was localized by immunohistochemistry using streptavidin-biotin-peroxidase complex or silver-intensified immunogold techniques in aortic, iliac and femoral samples obtained at surgery and autopsy from 32 patients. DAF was localized on the cells and in the connective tissue matrix of the arterial wall. Fibrous plaques and intimal thickenings presented larger amounts than fatty streaks, intimae and normal areas. By Western blotting analysis, DAF extracted from the arterial wall had a molecular weight of about 67 kDa. Using a double-labeling technique, DAF and C5b-9 complexes were co-localized on nucleated cells and on cell debris. The cells isolated after enzyme digestion of the arterial wall were tested for the protective role of DAF to complement-mediated damage. When DAF of the sensitized cells was blocked by monoclonal antibodies, complement-mediated cell lysis was enhanced from 10-15% to 60-70%. The effect of anti-DAF antibodies was dose-dependent. DAF blocking in the absence of antibodies used for sensitization led to a lysis under 10%. These data suggest a protective role of DAF against autologous complement activation, however insufficient to prevent complement activation in the human atherosclerotic wall. 相似文献
996.
Helge Draeger Jawad Salman Khalil Aburahma Lena S. Becker Thierry Siemeni Dietmar Boethig Wiebke Sommer Murat Avsar Dmitry Bobylev Nicolaus Schwerk Carsten Müller Mark Greer Jens Gottlieb Tobias Welte Marius M. Hoeper Jan B. Hinrichs Igor Tudorache Christian Kühn Axel Haverich Gregor Warnecke Fabio Ius 《Transplant international》2021,34(3):474-487
This study evaluated the impact of unilateral diaphragm elevation following bilateral lung transplantation on postoperative course. Patient data for all lung transplantations performed at our institution between 01/2010 and 12/2019 were reviewed. Presence of right or left diaphragm elevation was retrospectively evaluated using serial chest X-rays performed while patients were standing and breathing spontaneously. Right elevation was defined by a > 40 mm difference between right and left diaphragmatic height. Left elevation was present if the left diaphragm was at the same height or higher than the right diaphragm. In total, 1093/1213 (90%) lung transplant recipients were included. Of these, 255 (23%) patients exhibited radiologic evidence of diaphragm elevation (right, 55%; left 45%; permanent, 62%). Postoperative course did not differ between groups. Forced expiratory volume in 1 second, forced vital capacity and total lung capacity were lower at 1-year follow-up in patients with permanent than in patients with transient or absent diaphragmatic elevation (P = 0.038, P < 0.001, P = 0.002, respectively). Graft survival did not differ between these groups (P = 0.597). Radiologic evidence of diaphragm elevation was found in 23% of our lung transplant recipients. While lung function tests were worse in patients with permanent elevation, diaphragm elevation did not have any relevant impact on outcomes. 相似文献
997.
998.
Rianne Schutter Veerle A. Lantinga Tim L. Hamelink Merel B. F. Pool Otis C. van Varsseveld Jan Hendrik Potze Jan-Luuk Hillebrands Marius C. van den Heuvel Rudi A. J. O. Dierckx Henri G. D. Leuvenink Cyril Moers Ronald J. H. Borra 《Transplant international》2021,34(9):1643-1655
Acceptance criteria of deceased donor organs have gradually been extended toward suboptimal quality, posing an urgent need for more objective pre-transplant organ assessment. Ex vivo normothermic machine perfusion (NMP) combined with magnetic resonance imaging (MRI) could assist clinicians in deciding whether a donor kidney is suitable for transplantation. Aim of this study was to characterize the regional distribution of perfusate flow during NMP, to better understand how ex vivo kidney assessment protocols should eventually be designed. Nine porcine and 4 human discarded kidneys underwent 3 h of NMP in an MRI-compatible perfusion setup. Arterial spin labeling scans were performed every 15 min, resulting in perfusion-weighted images that visualize intrarenal flow distribution. At the start of NMP, all kidneys were mainly centrally perfused and it took time for the outer cortex to reach its physiological dominant perfusion state. Calculated corticomedullary ratios based on the perfusion maps reached a physiological range comparable to in vivo observations, but only after 1 to 2 h after the start of NMP. Before that, the functionally important renal cortex appeared severely underperfused. Our findings suggest that early functional NMP quality assessment markers may not reflect actual physiology and should therefore be interpreted with caution. 相似文献
999.
Steven D. Nathan Vincent Cottin Juergen Behr Marius M. Hoeper Fernando J. Martinez Tamera J. Corte Anne M. Keogh Hanno Leuchte Nesrin Mogulkoc Silvia Ulrich Wim A. Wuyts Zhen Yao Julia Ley-Zaporozhan Ullrich G. Müller-Lisse Frank-Detlef Scholle Günther Brüggenwerth Dennis Busse Sylvia Nikkho Athol U. Wells 《The Journal of heart and lung transplantation》2021,40(6):494-503