全文获取类型
收费全文 | 73篇 |
免费 | 14篇 |
专业分类
儿科学 | 2篇 |
基础医学 | 9篇 |
口腔科学 | 2篇 |
临床医学 | 19篇 |
内科学 | 10篇 |
神经病学 | 5篇 |
外科学 | 1篇 |
一般理论 | 2篇 |
预防医学 | 10篇 |
药学 | 26篇 |
肿瘤学 | 1篇 |
出版年
2022年 | 3篇 |
2021年 | 3篇 |
2020年 | 1篇 |
2019年 | 1篇 |
2018年 | 2篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 3篇 |
2014年 | 1篇 |
2013年 | 1篇 |
2012年 | 4篇 |
2011年 | 6篇 |
2010年 | 6篇 |
2009年 | 6篇 |
2008年 | 1篇 |
2006年 | 1篇 |
2005年 | 2篇 |
2004年 | 1篇 |
2003年 | 2篇 |
2002年 | 8篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1994年 | 1篇 |
1991年 | 4篇 |
1990年 | 2篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1987年 | 3篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1975年 | 1篇 |
1966年 | 2篇 |
排序方式: 共有87条查询结果,搜索用时 15 毫秒
11.
Patricia O’Campo Maritt Kirst Nicole Schaefer-McDaniel Michelle Firestone Allison Scott Kelly McShane 《Journal of urban health》2009,86(6):965-989
Consultations with community-based service providers in Toronto identified a lack of strong research evidence about successful
community-based interventions that address the needs of homeless clients experiencing concurrent mental health and substance
use disorders. We undertook a collaborative research effort between academic-based and community-based partners to conduct
a systematic evidence synthesis drawing heavily from Pawson’s realist review methodology to focus on both whether programs
are successful and why and how they lead to improved outcomes. We examined scholarly and nonscholarly literature to explore
program approaches and program elements that lead to improvements in mental health and substance use disorders among homeless
individuals with concurrent disorders (CD). Information related to program contexts, elements, and successes and failures
were extracted and further supplemented by key informant interviews and author communication regarding reviewed published
studies. From the ten programs that we reviewed, we identified six important and promising program strategies that reduce
mental health and, to a far lesser degree, substance use problems: client choice in treatment decision-making, positive interpersonal
relationships between client and provider, assertive community treatment approaches, providing supportive housing, providing
supports for instrumental needs, and nonrestrictive program approaches. These promising program strategies function, in part,
by promoting and supporting autonomy among homeless adults experiencing CD. Our realist informed review is a useful methodology
for synthesizing complex programming information on community-based interventions. 相似文献
12.
Quality systems and total process control in blood banking 总被引:3,自引:0,他引:3
Blood banking has dramatically changed in the past few years. Is the old business hierarchy and medical model for management still workable? How do we want to organize our work today for success in the future? Implementation of quality systems may seem overwhelmingly complex at this time to many blood banking establishments. However, by methodically adhering to the requirements of organization development described in this review, blood centers can achieve goals of quality improvement and TPC. The FDA and the pharmaceuticals and medical device industries have set the direction and provided guidance to blood establishments. The AABB, American Society for Quality Control, the American Society for Training and Development, and numerous other professional organizations can contribute information and materials. The FDA's document on quality assurance and the CFR are the basic texts guiding the approach presented in this paper. The organization's structure and processes may need to be reengineered to meet the requirements of a culture based on quality and process control. 相似文献
13.
In Canada, illicit drug use and addiction have traditionally been considered as a criminal justice problem and have been addressed from a legal perspective. Over the past century, a medical approach to drug addiction has slowly crept into the criminal justice processing of drug offenders. This has happened through the combination of principles of punishment with principles of addiction treatment in the sentencing of drug offenders to create a distinct application of 'compulsory drug treatment' in Canada. However, this evolution has occurred sporadically over time, with punishment and coercion as predominantly the main approach to dealing with this population. This evolution has recently culminated in Canada with the development of two criminal justice approaches to dealing with the substance use problems of drug offenders that incorporate concepts of punishment and treatment more equally than ever before - conditional sentencing and drug courts. This paper outlines the historical evolution of concepts of 'compulsory treatment', discusses such examples of contemporary 'compulsory treatment' as conditional sentencing and drug courts, and analyses the implications, concerns and challenges associated with these tools currently used in the sentencing of drug offenders in the Canadian context. 相似文献
14.
Janet T. Lin Sarah Kirst Stevan Cuci Alexandra Klem Yi-Min She Andrew M. Kropinski Hany Anany 《Viruses》2022,14(11)
Shiga toxin-producing Escherichia coli (STEC) is one of the leading causes of foodborne illnesses in North America and can lead to severe symptoms, with increased fatality risk for young children. While E. coli O157:H7 remains the dominant STEC serotype associated with foodborne outbreaks, there has been an increasing number of non-O157 STEC outbreaks in recent years. For the food industry, lytic bacteriophages offer an organic, self-limiting alternative to pathogen reduction—one that could replace or reduce the use of chemical and physical food processing methods. From EHEC-enriched sewage, we isolated a novel bacteriophage, vB_EcoM-4HA13 (4HA13). Phenotypic characterizations revealed 4HA13 to possess a myoviral morphotype, with a high specificity to non-motile O111 serotype, and a long latent period (90 min). Through genomic analyses, this 52,401-bp dsDNA phage was found to contain 81 CDS, but no detectable presence of antibiotic resistance, integrase, or virulence genes. A BLASTn search for each of the identified 81 CDS yielded homologues with low levels of similarity. Comparison of RNA polymerase and terminase large subunit amino acid sequences led to the proposal and acceptance of a new bacteriophage family, Chaseviridae, with 4HA13 representing a new species and genus. The discovery of this phage has broadened our current knowledge of bacteriophage diversity. 相似文献
15.
16.
H A Kirst M Debono K E Willard B A Truedell J E Toth J R Turner D R Berry B B Briggs D S Fukuda V M Daupert 《The Journal of antibiotics》1986,39(12):1724-1735
A large group of ester derivatives of tylosin-related macrolides was prepared in which the hydroxyl groups at C-3 and C-4' were acylated by either chemical or biochemical methods. Most of the derivatives exhibited excellent in vitro antimicrobial activity. However, only the 3,4'-diacyl derivatives of tylosin and macrocin showed any significant improvements of in vivo efficacy against experimental infections in rodents. 相似文献
17.
Comparison of aminoglycoside antibiotics with respect to uptake and lethal activity in Escherichia coli 总被引:1,自引:0,他引:1
Forty-five aminoglycoside antibiotics and related compounds were compared for their ability to induce the accumulation of dihydrostreptomycin in Escherichia coli K12. The common aminoglycosides and a streptothricin antibiotic all induced enhanced uptake within a relatively narrow concentration range. These concentrations were lethal to the bacteria. Comparison of aminoacyl derivatives of tobramycin and apramycin, the latter synthesized utilizing transition-metal cations to selectively control the site of substitution, revealed that 1-N-aminoacyl modifications resulted in an increased ability to induce enhanced uptake. 2'-N-Aminoacyl modifications were also effective at inducing enhanced uptake, albeit without noticeable improvement over parent. The findings from this structure-activity comparison support the proposition that aminoglycosides share a common critical target (most likely the ribosome), which, when acted upon, results in both drug accumulation and killing. 相似文献
18.
H A Kirst J E Toth J A Wind M Debono K E Willard R M Molloy J W Paschal J L Ott A M Felty-Duckworth F T Counter 《The Journal of antibiotics》1987,40(6):823-842
A large series of C-23-modified derivatives of 5-O-mycaminosyltylonolide were synthesized, in which the C-23 hydroxyl group was replaced by halo, aryl ether or thioether, azido, amino or dialkylamino substituents via SN2 displacement reactions. The majority of derivatives possessed excellent in vitro activity against a variety of aerobic and anaerobic bacteria. While some of the compounds treated experimental infections in rodents by parenteral administration, none showed any significant efficacy or bioavailability after oral dosing. Novel rearrangement products were obtained from some of the reactions; these were identified as 13,23-cyclopropyl-12,22-exomethylene and 13,23-cyclopropyl-12-alkoxy derivatives. 相似文献
19.
The structure of A201A, a novel nucleoside antibiotic 总被引:1,自引:0,他引:1
H A Kirst D E Dorman J L Occolowitz N D Jones J W Paschal R L Hamill E F Szymanski 《The Journal of antibiotics》1985,38(5):575-586
The structure of the novel nucleoside antibiotic A201A has been determined by a combination of chemical and spectroscopic methods. It is composed of 6-dimethylaminopurine, 3-amino-3-deoxyribose, p-hydroxy-alpha-methylcinnamic acid, a novel unsaturated hexofuranose and 3,4-di-O-methylrhamnose. Structures have also been assigned to several related minor factors simultaneously isolated from the fermentation broth. These unique nucleosides have very interesting similarities and differences in structure with the known antibiotics puromycin and hygromycin A. 相似文献
20.
Herbert A. Kirst Diane G. Thompson Thalia I. Nicas 《Antimicrobial agents and chemotherapy》1998,42(5):1303-1304