全文获取类型
收费全文 | 2104篇 |
免费 | 131篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 51篇 |
妇产科学 | 30篇 |
基础医学 | 298篇 |
口腔科学 | 297篇 |
临床医学 | 172篇 |
内科学 | 409篇 |
皮肤病学 | 73篇 |
神经病学 | 138篇 |
特种医学 | 23篇 |
外科学 | 253篇 |
综合类 | 11篇 |
一般理论 | 4篇 |
预防医学 | 271篇 |
眼科学 | 11篇 |
药学 | 105篇 |
中国医学 | 7篇 |
肿瘤学 | 73篇 |
出版年
2023年 | 16篇 |
2022年 | 47篇 |
2021年 | 54篇 |
2020年 | 56篇 |
2019年 | 65篇 |
2018年 | 75篇 |
2017年 | 56篇 |
2016年 | 73篇 |
2015年 | 73篇 |
2014年 | 92篇 |
2013年 | 93篇 |
2012年 | 150篇 |
2011年 | 157篇 |
2010年 | 111篇 |
2009年 | 77篇 |
2008年 | 132篇 |
2007年 | 128篇 |
2006年 | 117篇 |
2005年 | 108篇 |
2004年 | 98篇 |
2003年 | 84篇 |
2002年 | 56篇 |
2001年 | 33篇 |
2000年 | 34篇 |
1999年 | 32篇 |
1998年 | 14篇 |
1996年 | 7篇 |
1995年 | 10篇 |
1994年 | 4篇 |
1993年 | 10篇 |
1992年 | 17篇 |
1991年 | 12篇 |
1990年 | 17篇 |
1989年 | 7篇 |
1988年 | 8篇 |
1987年 | 12篇 |
1986年 | 10篇 |
1985年 | 9篇 |
1984年 | 10篇 |
1983年 | 8篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 6篇 |
1971年 | 3篇 |
1970年 | 10篇 |
1969年 | 11篇 |
1968年 | 4篇 |
1965年 | 3篇 |
排序方式: 共有2236条查询结果,搜索用时 46 毫秒
61.
Gonzalo Garijo MA Pérez Calderón R de Argila Fernández-Durán D Rangel Mayoral JF 《Allergologia et immunopathologia》2005,33(4):238-240
BackgroundThe spectrum of cutaneous eruptions in association with calcium channel blockers is extensive, varying from exanthemas to severe adverse events. Reactions due to diltiazem occur more frequently than with other calcium channel blockers. Patch testing has been used as confirmatory testing in patients with extensive cutaneous reactions. Cross-reactivity among these drugs have not been established.MaterialWe present 3 patients: 1) A 54-year-old man developed a generalized eythema-multiformelike reaction followed by erythrodermia and exfoliative dermatitis 6-7 days after starting on diltiazem. The drug was stopped and remission was obtained with emollients and systemic corticosteroids and antihistamines within 12 days. 2) A 80-year-old woman experienced a pruritic exanthematous eruption on her trunk which evolved to generalized erythrodermia and superficial desquamation. This reaction appeared 10 days after taking diltiazem, and gradually improved in 10-12 days after discontinuation of this drug.3) A 79-year-old man presented with erythema and pruritus initially on the back, and then affecting thorax, extremities and face. He had started treatment with diltiazem three days before. Diltiazem was stopped and steroid and antihistamine therapy was given. His skin condition improved, but 3 days later the patient received verapamil with worsening of previous situation. He recovered within 7 days.Methods and resultsTwo to six months after the reaction, we carried out epicutaneous tests with calcium channel blockers from different groups. Diltiazem proved positive (at 48 and 96 hours) in the three patients; nifedipine was also positive in patient 2, and verapamil in patient 3. Controlled administration of verapamil was well tolerated in patient 2 after the reaction, and the patient 1 has taken nifedipine without problems.Conclusions1) We report 3 cases of cutaneous reactions due to diltiazem. 2) Epicutaneous tests have been useful for diagnosis. 3) As one of patients had positive patch tests to diltiazem and nifedipine, and other one with diltiazem and verapamil, more studies are needed to demonstrate cross reactions among calcium channel blockers. 相似文献
62.
63.
Laura Annaratone Marco Volante Sofia Asioli Nelson Rangel Gianni Bussolati 《Endocrine pathology》2013,24(2):83-91
The aim of this study was to assess the suitability of using real-time quantitative PCR (RT-qPCR) to characterize neuroendocrine (NE) tumors of the pancreas. For a series of tumors, we evaluated several genes of interest, and the data were matched with the “classical” immunohistochemical (IHC) features. In 21 cases, we extracted RNA from formalin-fixed paraffin-embedded (FFPE) blocks, and in nine cases, we also extracted RNA from fresh-frozen tissue. The RT-qPCR procedure was performed using two sets of customized arrays. The test using the first set, covering 96 genes of interest, was focused on assessing the feasibility of the procedure, and the results were used to select 18 genes indicative of NE differentiation, clinical behavior, and therapeutic responsiveness for use in the second set of arrays. Threshold cycle (Ct) values were used to calculate the fold-changes in gene expression using the 2-??Ct method. Statistical procedures were used to analyze the results, which were matched with the IHC and follow-up data. Material from fresh-frozen samples performed better in terms of the level of amplification, but acceptable and concordant results were also obtained from FFPE samples. In addition, high concordance was observed between the mRNA and protein expression levels of somatostatin receptor type 2A (R?=?0.52, p?=?0.016). Genes associated with NE differentiation, as well as the gastrin-releasing peptide receptor and O-6-methylguanine-DNA methyltransferase genes, were underexpressed, whereas angiogenesis-associated markers (CDH13 and SLIT2) were overexpressed in tissues with malignant behavior. The RT-qPCR procedure is practical and feasible in economic terms for the characterization of NE tumors of the pancreas and can complement morphological and IHC-based evaluations. Thus, the results of the RT-qPCR procedure might offer an objective basis for therapeutic choices. 相似文献
64.
65.
do Lago Eliel Scarpioni Ferreira Sabrina Garcia Idelmo Rangel Okamoto Roberta Mariano Ronaldo Clio 《Clinical oral investigations》2020,24(5):1637-1650
Clinical Oral Investigations - The effect of leucocyte- and platelet-rich fibrin (L-PRF), associated with DBBM (deproteinized bovine bone mineral; Bio-Oss®) was investigated and compared with... 相似文献
66.
Jürgen Rehm Carolin Kilian Carina Ferreira‐Borges David Jernigan Maristela Monteiro Charles D. H. Parry Zila M. Sanchez Jakob Manthey 《Drug and alcohol review》2020,39(4):301-304
Based on a literature search undertaken to determine the impacts of past public health crises, and a systematic review of the effects of past economic crises on alcohol consumption, two main scenarios—with opposite predictions regarding the impact of the current COVID‐19 pandemic on the level and patterns of alcohol consumption—are introduced. The first scenario predicts an increase in consumption for some populations, particularly men, due to distress experienced as a result of the pandemic. A second scenario predicts the opposite outcome, a lowered level of consumption, based on the decreased physical and financial availability of alcohol. With the current restrictions on alcohol availability, it is postulated that, for the immediate future, the predominant scenario will likely be the second, while the distress experienced in the first may become more relevant in the medium‐ and longer‐term future. Monitoring consumption levels both during and after the COVID‐19 pandemic will be necessary to better understand the effects of COVID‐19 on different groups, as well as to distinguish them from those arising from existing alcohol control policies. 相似文献
67.
Marcia F. da Silva Alexandre Y. Saito Valnice J. Peres Antonio C. Oliveira Alejandro M. Katzin 《Antimicrobial agents and chemotherapy》2015,59(8):5084-5087
Previous studies have shown that fosmidomycin, risedronate, and nerolidol exert antimalarial activity in vitro. We included squalestatin, an inhibitor of the isoprenoid metabolism in Erwinia uredovora, and found that combinations of compounds which act on different targets of the plasmodial isoprenoid pathway possess important supra-additivity effects. 相似文献
68.
69.
70.
The global distribution of average volume of alcohol consumption and patterns of drinking 总被引:8,自引:0,他引:8
Rehm J Rehn N Room R Monteiro M Gmel G Jernigan D Frick U 《European addiction research》2003,9(4):147-156
AIMS: To make quantitative estimates on a global basis of exposure of disease-relevant dimensions of alcohol consumption, i.e. average volume of alcohol consumption and patterns of drinking. DESIGN: Secondary data analysis. MEASUREMENTS: Level of average volume of drinking was estimated by a triangulation of data on per capita consumption and from general population surveys. Patterns of drinking were measured by an index composed of several indicators for heavy drinking occasions, an indicator of drinking with meals and an indicator of public drinking. Average volume of consumption was assessed by sex and age within each country, and patterns of drinking only by country; estimates for the global subregions were derived from the population-weighted average of the countries. For more than 90% of the world population, per capita consumption was known, and for more than 80% of the world population, survey data were available. FINDINGS: On the country level, average volume of alcohol consumption and patterns of drinking were independent. There was marked variation between WHO subregions on both dimensions. Average volume of drinking was highest in established market economies in Western Europe and the former Socialist economies in the Eastern part of Europe and in North America, and lowest in the Eastern Mediterranean region and parts of Southeast Asia including India. Patterns were most detrimental in the former Socialist economies in the Eastern part of Europe, in Middle and South America and parts of Africa. Patterns were least detrimental in Western Europe and in developed countries in the Western Pacific region (e.g., Japan). CONCLUSIONS: Although exposure to alcohol varies considerably between regions, the overall exposure by volume is quite high and patterns are relatively detrimental. The predictions for the future are not favorable, both with respect to average volume and to patterns of drinking. 相似文献