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71.
Talbi C Cabon J Baud M Bourjaily M de Boisséson C Castric J Bigarré L 《Archives of virology》2011,156(12):2133-2144
Despite the increasing impact of rhabdoviruses in European percid farming, the diversity of the viral populations is still
poorly investigated. To address this issue, we sequenced the partial nucleoprotein (N) and complete glycoprotein (G) genes
of nine rhabdoviruses isolated from perch (Perca fluviatilis) between 1999 and 2010, mostly from France, and analyzed six of them by immunofluorescence antibody test (IFAT). Using two
rabbit antisera raised against either the reference perch rhabdovirus (PRhV) isolated in 1980 or the perch isolate R6146,
two serogroups were distinguished. Meanwhile, based on partial N and complete G gene analysis, perch rhabdoviruses were divided
into four genogroups, A-B-D and E, with a maximum of 32.9% divergence (G gene) between isolates. A comparison of the G amino
acid sequences of isolates from the two identified serogroups revealed several variable regions that might account for antigenic
differences. Comparative analysis of perch isolates with other rhabdoviruses isolated from black bass, pike-perch and pike
showed some strong phylogenetic relationships, suggesting cross-host transmission. Similarly, striking genetic similarities
were shown between perch rhabdoviruses and isolates from other European countries and various ecological niches, most likely
reflecting the circulation of viruses through fish trade as well as putative transfers from marine to freshwater fish. Phylogenetic
relationships of the newly characterized viruses were also determined within the family Rhabdoviridae. The analysis revealed a genetic cluster containing only fish viruses, including all rhabdoviruses from perch, as well as
siniperca chuatsi rhabdovirus (SCRV) and eel virus X (EVEX). This cluster was distinct from the one represented by spring
viraemia of carp vesiculovirus (SVCV), pike fry rhabdovirus (PFRV) and mammalian vesiculoviruses. The new genetic data provided
in the present study shed light on the diversity of rhabdoviruses infecting perch in France and support the hypothesis of
circulation of these viruses between other hosts and regions within Europe. 相似文献
72.
Pascual-Leone A Freitas C Oberman L Horvath JC Halko M Eldaief M Bashir S Vernet M Shafi M Westover B Vahabzadeh-Hagh AM Rotenberg A 《Brain topography》2011,24(3-4):302-315
Brain plasticity can be conceptualized as nature's invention to overcome limitations of the genome and adapt to a rapidly changing environment. As such, plasticity is an intrinsic property of the brain across the lifespan. However, mechanisms of plasticity may vary with age. The combination of transcranial magnetic stimulation (TMS) with electroencephalography (EEG) or functional magnetic resonance imaging (fMRI) enables clinicians and researchers to directly study local and network cortical plasticity, in humans in vivo, and characterize their changes across the age-span. Parallel, translational studies in animals can provide mechanistic insights. Here, we argue that, for each individual, the efficiency of neuronal plasticity declines throughout the age-span and may do so more or less prominently depending on variable 'starting-points' and different 'slopes of change' defined by genetic, biological, and environmental factors. Furthermore, aberrant, excessive, insufficient, or mistimed plasticity may represent the proximal pathogenic cause of neurodevelopmental and neurodegenerative disorders such as autism spectrum disorders or Alzheimer's disease. 相似文献
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76.
Boige V Malka D Elias D Castaing M De Baere T Goere D Dromain C Pocard M Ducreux M 《Annals of surgical oncology》2008,15(1):219-226
Background We have previously shown promising activity of hepatic arterial infusion (HAI) oxaliplatin combined with intravenous (IV)
5-fluorouracil (5-FU) and leucovorin (LV) as first-line chemotherapy in patients with colorectal liver metastases (CRLM) (intent-to-treat
[ITT] objective response rate [ORR], 64%; secondary resection rate, 18%; overall survival [OS], 27 months). Whether this regimen
could be beneficial after systemic chemotherapy failure is unknown.
Methods Patients with unresectable CRLM and history of systemic chemotherapy failure were treated bimonthly with HAI oxaliplatin (100
mg/m2 2 hours) combined with IV LV and IV bolus and infusional 5FU (modified LV5FU2 regimen).
Results Forty-four consecutive patients (median age 56 years; median number of prior systemic chemotherapy regimens, 2 range 1–5)
were included, of whom 43 (98%) had previously received oxaliplatin (n = 34), irinotecan (n = 37), or both (n = 28). Patients received a median of nine cycles of HAI oxaliplatin and IV modified LV5FU2 (range 0–25). Toxicity included
grade 3–4 neutropenia (43%), grade 2–3 neuropathy (43%), and grade 3–4 abdominal pain (14%). We observed 24 partial ORs (62%)
among the 39 assessable patients (ITT ORR, 55%; 95% CI, 40–69%), including 17, 12, and 12 patients who had failed to respond
to prior systemic chemotherapy with FOLFIRI, FOLFOX, or both, respectively. Tumor response allowed further R0 surgical resection
(n = 7) or radiofrequency ablation (n = 1) of initially unresectable CRLM in eight patients (18%). Median progression-free survival and OS were 7 and 16 months,
respectively.
Conclusions HAI oxaliplatin and IV LV5FU2 is feasible, safe, and shows promising activity after systemic chemotherapy failure, allowing
surgical resection of initially unresectable CRLM in 18% of patients. 相似文献
77.
Darosa Lim M.D. Marine Aussedat D.Pharm. Nicole Maillet‐Lebel M.D. Danielle Marcoux M.D. 《Pediatric dermatology》2017,34(5):e257-e259
Flagellate dermatitis, a cutaneous eruption in which the patient appears to have been whipped, has been described with antineoplastic agents and shiitake mushroom ingestion. A 15‐year‐old girl with metastatic Ewing sarcoma developed pruritic erythematous linear lesions on her trunk that became hyperpigmented over time during her first cycle of chemotherapy with doxorubicin, vincristine, cyclophosphamide, and ganitumab. Flagellate dermatitis was diagnosed based on clinical and histologic findings. Flagellate dermatitis (FD) is a rare cutaneous eruption named for its appearance, in which the patient appears to have been whipped. It has been associated with chemotherapeutic agents such as bleomycin 1 . We report FD in a child that occurred during chemotherapy treatment that included doxorubicin. 相似文献
78.
Benjamin Bouyer MD Zakaria Jalal MD PhD F. Daniel Ramirez MD Nicolas Derval MD Xavier Iriart MD Josselin Duchateau MD PhD François Roubertie MD PhD Nadir Tafer MD Romain Tixier MD Thomas Pambrun MD Ghassen Cheniti MD Ciro Ascione MD Masaaki Yokoyama MD Christopher Kowalewski MD Samuel Buliard MD Rémi Chauvel MD Marine Arnaud MD Mélèze Hocini MD Michel Haïssaguerre MD Pierre Jaïs MD PhD Hubert Cochet MD PhD Jean-Benoit Thambo MD PhD Frederic Sacher MD PhD 《Journal of cardiovascular electrophysiology》2023,34(6):1395-1404
Aim
Ventricular arrhythmias (VAs) are the most common cause of death in patients with repaired Tetralogy of Fallot (rTOF). However, risk stratifying remains challenging. We examined outcomes following programmed ventricular stimulation (PVS) with or without subsequent ablation in patients with rTOF planned for pulmonary valve replacement (PVR).Methods
We included all consecutive patients with rTOF referred to our institution from 2010 to 2018 aged ≥18 years for PVR. Right ventricular (RV) voltage maps were acquired and PVS was performed from two different sites at baseline, and if non-inducible under isoproterenol. Catheter and/or surgical ablation was performed when patients were inducible or when slow conduction was present in anatomical isthmuses (AIs). Postablation PVS was undertaken to guide implantable cardioverter-defibrillator (ICD) implantation.Results
Seventy-seven patients (36.2 ± 14.3 years old, 71% male) were included. Eighteen were inducible. In 28 patients (17 inducible, 11 non-inducible but with slow conduction) ablation was performed. Five had catheter ablation, surgical cryoablation in 9, both techniques in 14. ICDs were implanted in five patients. During a follow-up of 74 ± 40 months, no sudden cardiac death occurred. Three patients experienced sustained VAs, all were inducible during the initial EP study. Two of them had an ICD (low ejection fraction for one and important risk factor for arrhythmia for the second). No VAs were reported in the non-inducible group (p < .001).Conclusion
Preoperative EPS can help identifying patients with rTOF at risk for VAs, providing an opportunity for targeted ablation and may improve decision-making regarding ICD implantation. 相似文献79.
Disruption of Conscious Access in Psychosis Is Associated with Altered Structural Brain Connectivity
Lucie Berkovitch Lucie Charles Antoine Del Cul Nora Hamdani Marine Delavest Samuel Sarrazin Jean-Franois Mangin Pamela Guevara Ellen Ji Marc-Antoine d'Albis Raphaël Gaillard Frank Bellivier Cyril Poupon Marion Leboyer Ryad Tamouza Stanislas Dehaene Josselin Houenou 《The Journal of neuroscience》2021,41(3):513
According to global neuronal workspace (GNW) theory, conscious access relies on long-distance cerebral connectivity to allow a global neuronal ignition coding for conscious content. In patients with schizophrenia and bipolar disorder, both alterations in cerebral connectivity and an increased threshold for conscious perception have been reported. The implications of abnormal structural connectivity for disrupted conscious access and the relationship between these two deficits and psychopathology remain unclear. The aim of this study was to determine the extent to which structural connectivity is correlated with consciousness threshold, particularly in psychosis. We used a visual masking paradigm to measure consciousness threshold, and diffusion MRI tractography to assess structural connectivity in 97 humans of either sex with varying degrees of psychosis: healthy control subjects (n = 46), schizophrenia patients (n = 25), and bipolar disorder patients with (n = 17) and without (n = 9) a history of psychosis. Patients with psychosis (schizophrenia and bipolar disorder with psychotic features) had an elevated masking threshold compared with control subjects and bipolar disorder patients without psychotic features. Masking threshold correlated negatively with the mean general fractional anisotropy of white matter tracts exclusively within the GNW network (inferior frontal-occipital fasciculus, cingulum, and corpus callosum). Mediation analysis demonstrated that alterations in long-distance connectivity were associated with an increased masking threshold, which in turn was linked to psychotic symptoms. Our findings support the hypothesis that long-distance structural connectivity within the GNW plays a crucial role in conscious access, and that conscious access may mediate the association between impaired structural connectivity and psychosis. 相似文献
80.
The present study was aimed at investigating how print experience as a cultural factor influences directional tendencies in children’s drawing in the interplay with biomechanical (hand), syntactic (shape orientation) and semantic (shape meaning) factors. Eighty-eight right-handed children from three literacy/age groups (preliterate, first graders and third graders) had to copy a geometrical shape adapted from the Rey–Osterrieth complex figure. The shape was presented alternatively leftward and rightward, while using both dominant (right) and non-dominant (left) hands. Directional tendencies were assessed regarding directionality of drawing movements at global, intermediate and local levels and deviation error in centre line bisection. Results show a global improvement of drawing quality and strategies across groups and an advantage for the dominant right hand from 6 years onward. Regarding directional tendencies, a reinforcement of a congruency effect between conditions and writing direction was found from preliterates to third graders. These results are discussed as a cultural embodiment process and have implications for psychological testing. 相似文献