全文获取类型
收费全文 | 67794篇 |
免费 | 3693篇 |
国内免费 | 148篇 |
专业分类
耳鼻咽喉 | 867篇 |
儿科学 | 1499篇 |
妇产科学 | 1369篇 |
基础医学 | 9026篇 |
口腔科学 | 2605篇 |
临床医学 | 5201篇 |
内科学 | 16916篇 |
皮肤病学 | 1658篇 |
神经病学 | 5996篇 |
特种医学 | 1540篇 |
外科学 | 9131篇 |
综合类 | 285篇 |
一般理论 | 26篇 |
预防医学 | 5858篇 |
眼科学 | 1294篇 |
药学 | 4451篇 |
中国医学 | 252篇 |
肿瘤学 | 3661篇 |
出版年
2024年 | 48篇 |
2023年 | 451篇 |
2022年 | 209篇 |
2021年 | 1124篇 |
2020年 | 655篇 |
2019年 | 1187篇 |
2018年 | 2089篇 |
2017年 | 1251篇 |
2016年 | 1334篇 |
2015年 | 2032篇 |
2014年 | 2070篇 |
2013年 | 3010篇 |
2012年 | 5930篇 |
2011年 | 5810篇 |
2010年 | 2650篇 |
2009年 | 1952篇 |
2008年 | 4921篇 |
2007年 | 5108篇 |
2006年 | 5294篇 |
2005年 | 4993篇 |
2004年 | 4506篇 |
2003年 | 4038篇 |
2002年 | 3921篇 |
2001年 | 1566篇 |
2000年 | 2079篇 |
1999年 | 996篇 |
1998年 | 210篇 |
1997年 | 150篇 |
1996年 | 155篇 |
1995年 | 142篇 |
1994年 | 109篇 |
1993年 | 107篇 |
1992年 | 120篇 |
1991年 | 110篇 |
1990年 | 72篇 |
1989年 | 76篇 |
1988年 | 54篇 |
1987年 | 51篇 |
1986年 | 66篇 |
1985年 | 73篇 |
1984年 | 93篇 |
1983年 | 59篇 |
1982年 | 77篇 |
1981年 | 68篇 |
1980年 | 73篇 |
1979年 | 43篇 |
1978年 | 38篇 |
1977年 | 37篇 |
1976年 | 34篇 |
1974年 | 33篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
993.
994.
995.
An introduction of the role of probiotics in human infections and autoimmune diseases 总被引:1,自引:0,他引:1
Helioswilton Sales-Campos Siomar Castro Soares Carlo José Freire Oliveira 《Critical reviews in microbiology》2013,39(4):413-432
AbstractDuring the last decades, studies exploring the role of microorganisms inhabiting human body in different scenarios have demonstrated the great potential of modulating them to treat and prevent diseases. Among the most outstanding applications, probiotics have been used for over a century to treat infections and inflammation. Despite the beneficial role of other probiotics, Lactobacillus and Bifidobacterium species are the most frequently used, and have been effective as a therapeutic option in the treatment/prevention of dental caries, periodontal diseases, urogenital infections, and gastrointestinal infections. Additionally, as gastrointestinal tract harbors a great diversity of microbial species that directly or indirectly modulate host metabolism and immune response, the influence of intestinal microbiota, one of the targets of therapies using probiotics, on the biology of immune cells can be explored to treat inflammatory disorders or immune-mediated diseases. Thus, it is not surprising that probiotics have presented promising results in modulating human inflammatory diseases such as type 1 diabetes, multiple sclerosis, rheumatoid arthritis and inflammatory bowel disease, among others. Hence, the purpose of this review is to discuss the potential of therapeutic approaches using probiotics to constrain infection and development of inflammation on human subjects. 相似文献
996.
997.
998.
Pérez-Sayáns Mario González-Juanatey José R. Lorenzo-Pouso Alejandro I. Chamorro-Petronacci Cintia M. Blanco-Carrión Andrés Marichalar-Mendía Xabier Somoza-Martín José M. Suárez-Quintanilla Juan A. 《Odontology / the Society of the Nippon Dental University》2021,109(3):574-584
Odontology - The objective of this paper is to clarify the rate of abdominal obesity (AO), waist-to-height ratio (WHtR), metabolic syndrome (MetS) and determine the relationship with the... 相似文献
999.
Mahmoud Maasrani Agnès Drochon Majid Harmouche Hervé Corbineau Jean-Philippe Verhoye 《Medical engineering & physics》2013,35(1):103-107
In this work, patients with severe coronary disease and chronic occlusion of the right coronary artery (RCA) are studied. In this clinical situation, the collateral circulation is an important factor in the preservation of the myocardium until reperfusion of the area at risk. An accurate estimation of collateral flow is crucial in surgical bypass planning as it can influence the outcome of a given treatment for a given patient. The evaluation of collateral flow is frequently achieved using an index (CFI, Collateral Flow Index) based on pressure measurements.Using a model of the coronary circulation based on hydraulic/electric analogy, we demonstrate, through theoretical simulations, that a wide range of fractional collateral flow values can be obtained for any given distal pressure difference depending on the values of the capillary and collateral resistances. 相似文献
1000.
Alberto Antonicelli Stefano Cafarotti Alice Indini Alessio Galli Andrea Russo Alfredo Cesario Filippo Maria Lococo Patrizia Russo Alberto Franco Mainini Luca Giuseppe Bonifati Mario Nosotti Luigi Santambrogio Stefano Margaritora Pierluigi Maria Granone André Emanuel Dutly 《International journal of medical sciences》2013,10(3):320-330
The two essential requirements for pathologic specimens in the era of personalized therapies for non-small cell lung carcinoma (NSCLC) are accurate subtyping as adenocarcinoma (ADC) versus squamous cell carcinoma (SqCC) and suitability for EGFR molecular testing, as well as for testing of other oncogenes such as EML4-ALK and KRAS. Actually, the value of EGFR expressed in patients with NSCLC in predicting a benefit in terms of survival from treatment with an epidermal growth factor receptor targeted therapy is still in debate, while there is a convincing evidence on the predictive role of the EGFR mutational status with regard to the response to tyrosine kinase inhibitors (TKIs).This is a literature overview on the state-of-the-art of EGFR oncogenic mutation in NSCLC. It is designed to highlight the preclinical rationale driving the molecular footprint assessment, the progressive development of a specific pharmacological treatment and the best method to identify those NSCLC who would most likely benefit from treatment with EGFR-targeted therapy. This is supported by the belief that a rationale for the prioritization of specific regimens based on patient-tailored therapy could be closer than commonly expected. 相似文献