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51.
Lynn Marie Trotti David B Rye Donald L Bliwise 《Movement disorders》2007,22(10):1520; author reply 1520-1520; author reply 1521
52.
Propriospinal myoclonus: utility of magnetic resonance diffusion tensor imaging and fiber tracking. 总被引:1,自引:0,他引:1
Emmanuel Roze Emmanuelle Apartis Marie Vidailhet Valérie Cochen Yara Beaugendre Jean-Marc Trocello Pierre Lasjaunias Denis Ducreux 《Movement disorders》2007,22(10):1506-1509
Propriospinal myoclonus (PSM) is a rare movement disorder characterized by involuntary spinal-generated muscular jerks that spread rostrally and caudally to other spinally innervated muscles. Most patients have no clear etiology, and conventional MRI of the spinal cord is generally normal. Here we report the use of magnetic resonance diffusion tensor imaging (DTI) and fiber tracking to detect tract-specific abnormalities in a patient with propriospinal myoclonus. As the patient had the fragile-X premutation and antithyroid antibodies, spinal cord DTI abnormalities may be related to these conditions. Tract-specific analysis may provide new insights into the pathophysiology of propriospinal myoclonus. 相似文献
53.
In this observational study, we sought to assess the usefulness of pH values from residuals in intensive care unit (ICU) patients with small-bore feeding tubes. A review of the literature demonstrated that most critically ill patients were excluded in previous studies on gastric pH testing, suggesting that pH testing in critical care is not warranted. Our results demonstrated that 21% of intestinal testing and 64% of gastric testing yielded potential misinformation to the bedside nurse with regards to possible tube location. In conclusion, pH testing for small-bore tube placement and maintenance was not deemed meaningful in our critical care unit. 相似文献
54.
55.
56.
Hiroaki Nakamura Marie Yamada Makoto Fukae Hidehiro Ozawa 《Journal of bone and mineral metabolism》1997,15(4):184-192
We investigated the immunohistochemical localization of CD44, hyaluronate receptor, and moesin, of the ezrinradixin-moesin
(ERM) family, in osteoclasts after calcitonin adminstration using confocal laser scanning microscopy and transmission electron
microscopy to clarify the role of CD44 and moesin in their cytoskeletal organization and cell polarity. We also elucidated
the localization of osteopontin (OPN) to confirm its possible role in cell-matrix recognition via CD44. In untreated mice,
intense immunoreactivities for CD44 and moesin were detected on the basolateral plasma membrane of osteoclasts. Rhodamine-phalloidin
reactivity was seen in a bandlike pattern on the region of contact between osteoclasts and bone and was also detected moderately
along their basolateral plasma membrane. At 30 min after calcitonin administration, osteoclasts did not show either clear
zones or ruffled borders. The bandlike reactivity of rhodamine-phalloidin in the contact region was diminished, although labeling
was seen along osteoclasts. CD44 and moesin were colocalized along their plasma membranes, including the region facing the
bone surface. Electron microscopic observation revealed that the microvillus processes in the contacting region with bone
surface, as well as the basolateral plasma membrane, showed immunoreactivities to CD44 and moesin. At 60 min, some osteoclasts
attached to bone and showed a bandlike pattern of rhodamine-phalloidin. On the other hand, OPN was localized under CD44-positive
cytoplasmic processes and the clear zone of osteoclasts. These findings suggest that calcitonin effects on the cell polarity
of osteoclasts and the CD44-moesin-actin filament system in osteoclasts plays an imporant role in cell polarity and cell-matrix
recognition. 相似文献
57.
The AIDS epidemic has caused hysteria among the public and concern to many healthcare workers in the past 12 years. Currently, legislation exists for mandatory AIDS testing in some populations. The questions remain: Should healthcare workers be routinely tested? If so, is mandatory testing ethical? The author explores the incidence and prevalence of AIDS among healthcare workers, discusses why mandatory testing for healthcare workers is an issue, and examines the legal and ethical principles involved in mandatory testing. 相似文献
58.
59.
Marie V. St-Pierre K. Sandy Pang 《Journal of pharmacokinetics and pharmacodynamics》1995,23(3):243-266
Previous mouse liver studies with diazepam (DZ),N-desmethyldiazepam (NZ), and temazepam (TZ) confirmed that under first-order conditions, DZ formed NZ and TZ in parallel.
Oxazepam (OZ) was generatedvia NZ and not TZ despite that preformed NZ and TZ were both capable of forming OZ. In the present studies, the concentration-dependent
sequential metabolism of DZ was studied in perfused mouse livers and microsomes, with the aim of distinguishing the relative
importance of NZ and TZ as precusors of OZ. In microsomal studies, theK
ms andV
maxs, corrected for binding to microsomal proteins, were 34 μM and 3.6 nmole/min per mg and 239 μM and 18 nmole/min per mg, respectively,
forN-demthylation andC
3-hydroxylation of DZ. TheK
ms andV
maxs forN-demethylation andC
3-hydroxylation of TZ and NZ, respectively, to form OZ, were 58 μM and 2.5 nmole/min per mg and 311 μM and 2 nmole/min per
mg, respectively. The constants suggest that at low DZ concentrations, NZ formation predominates and is a major source of
OZ, whereas at higher DZ concentrations, TZ is the important source of OZ. In livers perfused with DZ at input concentrations
of 13 to 35 μM, the extraction ratio of DZ (E{DZ}) decreased from 0.83 to 0.60. NZ was the major metabolite formed although its appearance was less than proportionate
with increasing DZ input concentration. By contrast, the formation of TZ increased disporportionately with increasing DZ concentration,
whereas that for OZ decreased and paralleled the behavior of NZ. Computer simulations based on a tubular flow model and thein vitro enzymatic parameters provided a poorin vitro-organ correlation. TheE{DZ}, appearance rates of the metabolites, and the extraction ratio of formed NZ (E{NZ, DZ}) were poorly predicted; TZ was incorrectly identified as the major precursor of OZ. Simulations with optimized parameters
imporved the correlations and identified NZ as the major contributor of OZ. Saturation of DZN-demethylation at higher DZ concentrations increased the role of TZ in the formation of OZ. The poor aqueous solubility (limiting
the concentration range of substrates usedin vitro), avid tissue binding and the coupling of enzymatic reactions in liver, favoring sequential metabolism, are possible explanations
for the poorin vitro-organ correlation. This work emphasizes the complexity of the hepatic intracellular milieu for drug metabolism and the need
for additional modeling efforts to adequately describe metabolite kinetics.
This work was supported by the Medical Research Council of Canada (MA-9104). 相似文献
60.
Erica KNEIPP Richard MURRAY Kevin WARR Cherelle FITZCLARENCE Marie WEARNE Graeme MAGUIRE 《Nephrology (Carlton, Vic.)》2004,9(S4):S121-S125
SUMMARY: The incidence of end-stage renal failure (ESRF) in the Kimberley region at the top end of Western Australia far exceeds known national rates and trend analysis demonstrates a close parallel to what is occurring in the Northern Territory. Dialysis prevalence in the Kimberley has nearly tripled in the last decade and has increased at a much faster rate than the rest of Western Australia. Almost all of these people with ESRF are Aboriginal Australians living in remote communities.
In January 2004, the Western Australia Country Health Service and Kimberley Aboriginal Medical Services' Council, under the auspices of the Kimberley Aboriginal Health Planning Forum, embarked upon a review of renal disease in the Kimberley funded by the Western Australia Department of Health. The main purpose of the review was to identify the scope of the problem and make projections upon which to base programme and service development over the next 10 years.
This paper outlines the findings of the Review of Renal Disease in the Kimberley and presents, for the first time, regional data analysis and comparisons. In addition, future projections on the impact of ESRF and recommendations for improving current service delivery are discussed. Given the challenges of remoteness and individuals' desire to return home, this review recommends development of locally-based expertise capable of providing training and support to patients and their families, reinvigoration of community-based dialysis modalities, and the initiation of planning for a second satellite service in the Kimberley. 相似文献
In January 2004, the Western Australia Country Health Service and Kimberley Aboriginal Medical Services' Council, under the auspices of the Kimberley Aboriginal Health Planning Forum, embarked upon a review of renal disease in the Kimberley funded by the Western Australia Department of Health. The main purpose of the review was to identify the scope of the problem and make projections upon which to base programme and service development over the next 10 years.
This paper outlines the findings of the Review of Renal Disease in the Kimberley and presents, for the first time, regional data analysis and comparisons. In addition, future projections on the impact of ESRF and recommendations for improving current service delivery are discussed. Given the challenges of remoteness and individuals' desire to return home, this review recommends development of locally-based expertise capable of providing training and support to patients and their families, reinvigoration of community-based dialysis modalities, and the initiation of planning for a second satellite service in the Kimberley. 相似文献