全文获取类型
收费全文 | 688篇 |
免费 | 36篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 18篇 |
妇产科学 | 17篇 |
基础医学 | 94篇 |
口腔科学 | 12篇 |
临床医学 | 51篇 |
内科学 | 180篇 |
皮肤病学 | 15篇 |
神经病学 | 59篇 |
特种医学 | 10篇 |
外科学 | 50篇 |
综合类 | 6篇 |
预防医学 | 88篇 |
眼科学 | 7篇 |
药学 | 66篇 |
中国医学 | 14篇 |
肿瘤学 | 42篇 |
出版年
2024年 | 1篇 |
2023年 | 3篇 |
2022年 | 15篇 |
2021年 | 25篇 |
2020年 | 11篇 |
2019年 | 29篇 |
2018年 | 25篇 |
2017年 | 13篇 |
2016年 | 17篇 |
2015年 | 19篇 |
2014年 | 34篇 |
2013年 | 53篇 |
2012年 | 60篇 |
2011年 | 68篇 |
2010年 | 40篇 |
2009年 | 24篇 |
2008年 | 46篇 |
2007年 | 38篇 |
2006年 | 46篇 |
2005年 | 44篇 |
2004年 | 36篇 |
2003年 | 32篇 |
2002年 | 34篇 |
2001年 | 3篇 |
2000年 | 1篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1996年 | 4篇 |
1994年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
排序方式: 共有730条查询结果,搜索用时 0 毫秒
61.
62.
Herrera-Ruiz M Gutiérrez C Enrique Jiménez-Ferrer J Tortoriello J Mirón G León I 《Journal of ethnopharmacology》2007,112(2):243-247
Ipomoea stans Cav., popularly known as "tumbavaqueros", is a plant widely used in Mexico for the treatment of epileptic seizures and nervous disorders. This work researched the action of the ethyl acetate extract from the root of I. stans (IS-EAE) on the central nervous system (CNS). The administration of IS-EAE (2.5 and 5.0 mg/kg, i.p.) produced an anxiolytic effect in mice. This extract (20.0 and 40.0 mg/kg, i.p.) significantly reduced spontaneous motor activity. 2.5, 5.0, 10.0, and 20.0 mg/kg of IS-EAE protected mice against pentylenetetrazole-induced convulsions and increased the hypnotic effect induced by pentobarbital. The administration of IS-EAE was able to increase the release of GABA in brain cortex of mice. These results suggest that IS-EAE possess anxiolytic and anticonvulsant effects, and could have potential sedative effect, probably through a GABAergic system. The extract did not show antidepressant effects on mice exposed to forced swimming test. 相似文献
63.
64.
65.
66.
67.
Daniele Doná Juan Torres Canizales Elisa Benetti Mara Cananzi Federica De Corti Elisabetta Calore Loreto Hierro Esther Ramos Boluda Marta Melgosa Hijosa Luis Garcia Guereta Antonio Pérez Martínez Maribel Barrios Patricia Costa Reis Ana Teixeira Maria Francelina Lopes Piotr Kaliciński Sophie Branchereau Olivia Boyer Dominque Debray Marco Sciveres Lars Wennberg Björn Fischler Peter Barany Alastair Baker Ulrich Baumann Nicolaus Schwerk Emanuele Nicastro Manila Candusso Jacek Toporski Etienne Sokal Xavier Stephenne Caroline Lindemans Marius Miglinas Jelena Rascon Paloma Jara ERN TransplantChild 《Clinical transplantation》2020,34(10):e14063
The current pandemic SARS-CoV-2 has required an unusual allocation of resources that can negatively impact chronically ill patients and high-complexity procedures. Across the European Reference Network on Pediatric Transplantation (ERN TransplantChild), we conducted a survey to investigate the impact of the COVID-19 outbreak on pediatric transplant activity and healthcare practices in both solid organ transplantation (SOT) and hematopoietic stem cell transplantation (HSCT). The replies of 30 professionals from 18 centers in Europe were collected. Twelve of 18 centers (67%) showed a reduction in their usual transplant activity. Additionally, outpatient visits have been modified and restricted to selected ones, and the use of telemedicine tools has increased. Additionally, a total of 14 COVID-19 pediatric transplanted patients were identified at the time of the survey, including eight transplant recipients and six candidates for transplantation. Only two moderate-severe cases were reported, both in HSCT setting. These survey results demonstrate the limitations in healthcare resources for pediatric transplantation patients during early stages of this pandemic. COVID-19 disease is a major worldwide challenge for the field of pediatric transplantation, where there will be a need for systematic data collection, encouraging regular discussions to address the long-term consequences for pediatric transplantation candidates, recipients, and their families. 相似文献
68.
The presence of genomic imbalances is associated with poor outcome in patients with burkitt lymphoma treated with dose‐intensive chemotherapy including rituximab 下载免费PDF全文
Maribel Forero‐Castro Cristina Robledo Eva Lumbreras Rocio Benito Jesús M. Hernández‐Sánchez María Hernández‐Sánchez Juan L. García Luis A. Corchete‐Sánchez Mar Tormo Pere Barba Javier Menárguez Jordi Ribera Carlos Grande Lourdes Escoda Carmen Olivier Estrella Carrillo Alfonso García de Coca Josep‐María Ribera Jesús M. Hernández‐Rivas 《British journal of haematology》2016,172(3):428-438
The introduction of Rituximab has improved the outcome and survival rates of Burkitt lymphoma (BL). However, early relapse and refractoriness are current limitations of BL treatment and new biological factors affecting the outcome of these patients have not been explored. This study aimed to identify the presence of genomic changes that could predict the response to new therapies in BL. Forty adolescent and adult BL patients treated with the Dose‐Intensive Chemotherapy Including Rituximab (Burkimab) protocol (Spanish Programme for the Study and Treatment of Haematological Malignancies; PETHEMA) were analysed using array‐based comparative genomic hybridization (CGH). In addition, the presence of TP53, TCF3 (E2A), ID3 and GNA13 mutations was assessed by next‐generation sequencing (NGS). Ninety‐seven per cent of the patients harboured genomic imbalances. Losses on 11q, 13q, 15q or 17p were associated with a poor response to Burkimab therapy (P = 0·038), shorter progression‐free survival (PFS; P = 0·007) and overall survival (OS; P = 0·009). The integrative analysis of array‐CGH and NGS showed that 26·3% (5/19) and 36·8% (7/19) of patients carried alterations in the TP53 and TCF3 genes, respectively. TP53 alterations were associated with shorter PFS (P = 0·011) while TCF3 alterations were associated with shorter OS (P = 0·032). Genetic studies could be used for risk stratification of BL patients treated with the Burkimab protocol. 相似文献
69.
Differences in Selected HIV Care Continuum Outcomes Among People Residing in Rural,Urban, and Metropolitan Areas—28 US Jurisdictions 下载免费PDF全文
John A. Nelson PhD Anna Kinder MS Anna Satcher Johnson MPH H. Irene Hall PhD Xiaohong Hu MS Donna Sweet MD Alyssa Guido MPH Harold Katner MD Jennifer Janelle MD Maribel Gonzalez MSN Natalia Martínez Paz MA MPA Charlotte Ledonne BSN MA Jason Henry Theresa Bramel MHS Jeanne Harris BSN MBA 《The Journal of rural health》2018,34(1):63-70
Purpose
The HIV care continuum is used to monitor success in HIV diagnosis and treatment among persons living with HIV in the United States. Significant differences exist along the HIV care continuum between subpopulations of people living with HIV; however, differences that may exist between residents of rural and nonrural areas have not been reported.Methods
We analyzed the Centers for Disease Control and Prevention's National HIV Surveillance System data on adults and adolescents (≥13 years) with HIV diagnosed in 28 jurisdictions with complete reporting of HIV‐related lab results. Lab data were used to assess linkage to care (≥1 CD4 or viral load test ≤3 months of diagnosis), retention in care (≥2 CD4 and/or viral load tests ≥3 months apart), and viral suppression (viral load <200 copies/mL) among persons living with HIV. Residence at diagnosis was grouped into rural (<50,000 population), urban (50,000‐499,999 population), and metropolitan (≥500,000 population) categories for statistical comparison. Prevalence ratios and 95% CI were calculated to assess significant differences in linkage, retention, and viral suppression.Findings
Although greater linkage to care was found for rural residents (84.3%) compared to urban residents (83.3%) and metropolitan residents (81.9%), significantly lower levels of retention in care and viral suppression were found for residents of rural (46.2% and 50.0%, respectively) and urban (50.2% and 47.2%) areas compared to residents of metropolitan areas (54.5% and 50.8%).Conclusions
Interventions are needed to increase retention in care and viral suppression among people with HIV in nonmetropolitan areas of the United States. 相似文献70.