全文获取类型
收费全文 | 2415篇 |
免费 | 155篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 33篇 |
儿科学 | 54篇 |
妇产科学 | 57篇 |
基础医学 | 333篇 |
口腔科学 | 47篇 |
临床医学 | 215篇 |
内科学 | 550篇 |
皮肤病学 | 74篇 |
神经病学 | 329篇 |
特种医学 | 51篇 |
外科学 | 387篇 |
综合类 | 11篇 |
预防医学 | 149篇 |
眼科学 | 26篇 |
药学 | 105篇 |
中国医学 | 9篇 |
肿瘤学 | 148篇 |
出版年
2023年 | 15篇 |
2022年 | 41篇 |
2021年 | 64篇 |
2020年 | 41篇 |
2019年 | 66篇 |
2018年 | 70篇 |
2017年 | 52篇 |
2016年 | 62篇 |
2015年 | 74篇 |
2014年 | 83篇 |
2013年 | 122篇 |
2012年 | 176篇 |
2011年 | 140篇 |
2010年 | 92篇 |
2009年 | 75篇 |
2008年 | 113篇 |
2007年 | 123篇 |
2006年 | 125篇 |
2005年 | 110篇 |
2004年 | 129篇 |
2003年 | 104篇 |
2002年 | 88篇 |
2001年 | 57篇 |
2000年 | 61篇 |
1999年 | 44篇 |
1998年 | 18篇 |
1997年 | 21篇 |
1996年 | 17篇 |
1995年 | 4篇 |
1994年 | 17篇 |
1993年 | 6篇 |
1992年 | 43篇 |
1991年 | 33篇 |
1990年 | 29篇 |
1989年 | 33篇 |
1988年 | 39篇 |
1987年 | 36篇 |
1986年 | 17篇 |
1985年 | 22篇 |
1984年 | 15篇 |
1983年 | 18篇 |
1982年 | 13篇 |
1981年 | 9篇 |
1979年 | 11篇 |
1978年 | 9篇 |
1977年 | 5篇 |
1976年 | 4篇 |
1973年 | 5篇 |
1972年 | 4篇 |
1969年 | 4篇 |
排序方式: 共有2578条查询结果,搜索用时 15 毫秒
91.
Milk fistula is an uncommon condition which occurs when there is an abnormal connection that forms between the skin surface and the duct in the breast of a lactating woman, resulting in spontaneous and often constant drainage of milk from this path of least resistance. A milk fistula is usually a complication that results from a needle biopsy or surgical intervention in a lactating patient. Here, the authors present an unusual case of a spontaneous milk fistula which developed from an abscess in the breast of a lactating woman. The patient initially presented to the office with a large open wound on her breast, formed from skin breakdown, within which milk was pooling. She was treated with local wound care and cessation of breastfeeding, with appropriate healing of the wound and closure of the fistula with 6 weeks. Diagnosis, prevention, and treatment of milk fistula were reviewed. 相似文献
92.
Benedetta Miglino MD Rossana Tiberio MD Stefano Astolfi MD Francesca Graziola MD Paolo Boggio MD Monica Leutner MD Guido Valente MD Roberto Franchini MD Enrico Colombo MD 《The breast journal》2016,22(3):339-341
Basal cell carcinoma (BCC) is a common skin cancer worldwide. However, BCC of the nipple and areola complex is rare. Men are more affected than women. Most of the cases were treated with simple excision. We report a case of BCC of the right nipple–areola complex in a 75‐year‐old man, treated with Mohs surgery and simple mastectomy. 相似文献
93.
94.
Flávia Galvão Cândido Flávia Xavier Valente Łukasz Marcin Grześkowiak Ana Paula Boroni Moreira Daniela Mayumi Usuda Prado Rocha Rita de Cássia Gonçalves Alfenas 《International journal of food sciences and nutrition》2018,69(2):125-143
Dietary fat strongly affects human health by modulating gut microbiota composition and low-grade systemic inflammation. High-fat diets have been implicated in reduced gut microbiota richness, increased Firmicutes to Bacteroidetes ratio, and several changes at family, genus and species levels. Saturated (SFA), monounsaturated (MUFA), polyunsaturated (PUFA) and conjugated linolenic fatty acids share important pathways of immune system activation/inhibition with gut microbes, modulating obesogenic and proinflammatory profiles. Mechanisms that link dietary fat, gut microbiota and obesity are mediated by increased intestinal permeability, systemic endotoxemia, and the activity of the endocannabinoid system. Although the probiotic therapy could be a complementary strategy to improve gut microbiota composition, it did not show permanent effects to treat fat-induced dysbiosis. Based upon evidence to date, we believe that high-fat diets and SFA consumption should be avoided, and MUFA and omega-3 PUFA intake should be encouraged in order to regulate gut microbiota and inflammation, promoting body weight/fat control. 相似文献
95.
96.
97.
Mary Freyvogel DO Shilpa Padia MD Kelsey Larson MD Jill Dietz MD Stephen Grobmyer MD Colin O’Rourke MS Stephanie Valente DO 《Annals of surgical oncology》2014,21(10):3256-3260
Background
Currently, no standard guidelines exist regarding routine screening imaging in breast cancer patients following autologous reconstruction. Concern over nonpalpable chest wall recurrence has prompted many to pursue screening imaging. We analyzed the pattern of locoregional recurrence (LRR) and yield of screening imaging and exam in these patients.Methods
We performed a retrospective chart review of all patients who had mastectomy with autologous reconstruction between 2000 and 2009. Presentation of LRR and utility of imaging and breast exam were analyzed. Screening mammography was performed at the discretion of the treating physicians.Results
A total of 615 patients were identified and follow-up data were available for 541. Median follow-up from time of reconstruction was 7 years. Twenty-seven patients developed a LRR (5.0 %). Among patients screened with mammography (n = 397), an abnormality led to 25 biopsies in 25 patients, and 2 were malignant (8 %). Among patients receiving routine clinical exam (n = 537), an abnormality led to 77 biopsies in 66 patients, and 30 were malignant (39 %). The median time from cancer surgery to LRR was 2.6 years. LRR was detected on clinical exam in 24 of 27 patients (88.9 %). Screening mammography detected two recurrences that were palpable on follow-up exam. One patient had an incidental chest wall recurrence found on PET/CT. In summary, 26 of 27 (96.3 %) patients had a clinically detectable LRR.Conclusions
Diligent surveillance with clinical breast exam is a reliable method of detecting LRR after autologous reconstruction, identifying 96.3 % of recurrences in our study. Our results do not support routine mammographic screening in this population. 相似文献98.
Marina Macchini Marta Chiaravalli Chiara Pircher Silvia Zanon Umberto Peretti Elena Mazza Maria Maddalena Valente Clara Fugazza Luca Gianni Michele Reni 《Digestive and liver disease》2021,53(1):117-121
Background and AimsOlder patients with metastatic pancreatic adenocarcinoma (MPDAC) are under-represented in clinical trials.MethodsOur single-center, retrospective study enrolled MPDAC patients ≥ 70 treated with chemotherapyResults105 patients were divided in groups based on the received treatments: 44 gemcitabine or capecitabine monotherapy (A), 34 nabpaclitaxel-gemcitabine (B) 27 4-drugs combinations (gemcitabine, cisplatin, capecitabine plus either nab-paclitaxel or epirubicin or docetaxel) (C). Group A: median age was 78 (70–87) and Karnofsky performance status (KPS) ≥80 was found in 84% of patients; Group B: median age 77 (71–84) and KPS ≥ 80 in 88% of patients; Group C: median age 73 (70–78) and KPS ≥ 80 in 93% of patients. Median OS was 7.9, 11.7 and 14.2 months in group A, B and C respectively; 1 and 2-year OS were 27% and 8% in group A; 44% and 5% in group B; 52% and 22% in group C. When lung metastatic only patients were excluded, patients <75 and ≥ 75 had similar OS in group A (6.4 vs 5.6 months) and in group B (12.3 vs 11.1 months). In group B grade 3 thrombocytopenia, fatigue and peripheral neuropathy were more frequent in patients ≥ 75.ConclusionsIn older patients, combination chemotherapy shows acceptable feasibility and promising efficacy. 相似文献
99.
100.
Monoclonal antibodies to the thyrotropin receptor: stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease. 总被引:11,自引:1,他引:11
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
W A Valente P Vitti Z Yavin E Yavin C M Rotella E F Grollman R S Toccafondi L D Kohn 《Proceedings of the National Academy of Sciences of the United States of America》1982,79(21):6680-6684
Human monoclonal antibodies have been generated from heterohybridomas obtained by fusing mouse myeloma cells with peripheral lymphocytes from patients with active Graves disease. This report characterizes four antibodies as presumptive thyrotropin receptor antibodies because they specifically inhibit thyrotropin binding and competitively inhibit thyrotropin-induced cAMP levels in human thyroid cells. Two of these antibodies, 208F7 and 206H3, are representative of autoimmune stimulators in Graves disease sera because they stimulate thyroid function in all assays, including the mouse bioassay; their ability to inhibit thyrotropin-induced cAMP increases in thyroid cells competitively is complemented by more than additive agonism at low (10 pM) thyrotropin concentrations. These stimulating antibodies interact more potently with human thyroid ganglioside preparations than with bovine thyroid or brain gangliosides; in contrast, they are poor inhibitors of 125I-labeled thyrotropin binding to liposomes containing the glycoprotein component of the human thyrotropin receptor. Antibodies 129H8 and 122G3 appear to be representative of inhibiting or "blocking" antibodies in Graves disease sera. Thus they have no intrinsic stimulatory action in assays of thyroid function but rather inhibit thyrotropin activity in the assays tested. These two antibodies do not react with human thyroid gangliosides but are strong inhibitors of thyrotropin binding to liposomes containing the high-affinity glycoprotein component from human, bovine, and rat thyroid membranes. The data unequivocally establish the pluritopic nature of the immunoglobulins in Graves disease and relate individual components or determinants of the thyrotropin receptor structure with specific autoimmune immunoglobulins. 相似文献