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991.
Daniele P. Santos-Bezerra Ana Mercedes Cavaleiro Aritania Sousa Santos Claudia Kimie Suemoto Carlos Augusto Pasqualucci Wilson Jacob-Filho Renata Elaine Paraizo Leite Marisa Passarelli Suely Kazue Nagahashi Marie Ubiratan Fabres Machado Maria Lucia Correa-Giannella 《Alcoholism, clinical and experimental research》2021,45(1):64-68
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Daniele Piovani Maria Nefeli Christodoulou Andreas Hadjidemetriou Katerina Pantavou Paraskevi Zaza Pantelis G. Bagos Stefanos Bonovas Georgios K. Nikolopoulos 《The Journal of infection》2021,82(1):133-142
ObjectivesTo estimate the effect of early application of social distancing interventions on Covid-19 cumulative mortality during the first pandemic wave.MethodsEcological longitudinal study using multivariable negative binomial regression for panel data. Daily numbers of Covid-19 cases and deaths, and data on social distancing interventions, for the 37 member countries of the Organization for Economic Cooperation and Development (OECD) were analysed.ResultsCovid-19 cumulative mortality over the first pandemic wave varied widely across countries (range, 4.16 to 855 deaths per million population). On average, one-day delay in application of mass gatherings ban was associated with an adjusted increase in Covid-19 cumulative mortality by 6.97% (95% CI, 3.45 to 10.5), whilst a one-day delay in school closures was associated with an increase of 4.37% (95% CI, 1.58 to 7.17) over the study period. We estimated that if each country had enacted both interventions one week earlier, Covid-19 cumulative mortality could have been reduced by an average of 44.1% (95% CI, 20.2 to 67.9).ConclusionsEarly application of mass gatherings ban and school closures in outbreak epicentres was associated with an important reduction in Covid-19 cumulative mortality during the first pandemic wave. These findings may support policy decision making. 相似文献
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Saidy Vásconez Noguera Evelyn Patrícia Sánchez Espinoza Marina Farrel Côrtes Izabel Cristina Vilela Oshiro Fernanda de Sousa Spadão Laura Maria Brasileiro Brandão Ana Natiele da Silva Barros Sibeli Costa Bianca Leal de Almeida Paula Gemignani Soriano Alessandra Grassi Salles Mirian Elizabete Marques Escorcio Cristina Madeira Barretti Fernanda Spadotto Baptista Glaura Souza Alvarenga Igor Marinho Leila Suemi Harima Letaif Ho Ye Li Silvia Figueiredo Costa 《American journal of infection control》2021,49(4):512-515
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Javier Lucas Ramos Cristina Suárez Ferrer Joaquín Poza Cordón María Sánchez Azofra Jose Luis Rueda García Eduardo Martin Arranz Jorge Yebra Carmona Irene Andaluz García Maria Dolores Martín Arranz 《Gastroenterologia y hepatologia》2021,44(5):337-345
IntroductionThe dose of thiopurine drugs in combined treatments with anti-TNF in inflammatory bowel disease (IBD) has not been clearly established. The purpose of this study is to assess whether the dose of azathioprine influences clinical and biochemical response/remission rates, and anti-TNF drug levels/antibody formation.Material and methodsPatients with IBD on combined maintenance treatment with azathioprine and infliximab or adalimumab were selected. Based on the dose of azathioprine, two groups were defined (standard: 2–2.5 mg/kg/day; and decreased: less than 2 mg/kg/day).ResultsIn the IFX group, there were no statistically significant differences (p = 0.204) in the rates of remission (39% vs 41.3%), response (10% vs 21.7%) or failure (51.5% vs 37%) depending on the dose of thiopurine drugs. No differences were found between AZA-dose dependent IFX levels (2.46 vs 3.21 μg/mL; p = 0.211). In the adalimumab group, there were no statistically significant differences (p = 0.83) in the rates of remission (66% vs 56%), response without remission (15.38% vs 25%) or failure (18% vs 18%) depending on the dose of thiopurines. With respect to ADA-levels, no differences were found in both groups (7.69 vs 8.23 μg/mL; p = 0.37).ConclusionIn our experience, no statistically significant differences were found in either anti-TNF levels or clinical-biological response/remission rates based on doses of azathioprine. 相似文献
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Luduvico Karina Pereira Spohr Luiza de Aguiar Mayara Sandrielly Soares Teixeira Fernanda Cardoso Bona Natália Pontes de Mello Julia Eisenhardt Spanevello Roselia Maria Stefanello Francieli Moro 《Metabolic brain disease》2022,37(6):2133-2140
Metabolic Brain Disease - Acetylcholine is an excitatory neurotransmitter that modulates synaptic plasticity and communication, and it is essential for learning and memory processes. This... 相似文献