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71.
Erika Borlenghi Chiara Cattaneo Elisa Cerqui Silvana Archetti Diego Bertoli Daniela Bellotti Doriana Gramegna Giulia Soverini Margherita Oberti Francesca Schieppati Chiara Pagani Angela Passi Margherita Sciumé Mirko Farina Cecilia Carbone Claudia Crippa Daniela Dalceggio Alessandra Tucci Giuseppe Rossi 《Hematological oncology》2020,38(5):754-762
Consolidation treatment in acute myeloid leukemia (AML) patients achieving complete remission (CR) is warranted. High-dose cytarabine (HDAC) is considered first choice in favorable risk and an option in intermediate-risk AML. However, its optimal dose and schedule, as well as the benefit of additional chemotherapy agents remain controversial. Herein, we report on the long-term outcome of consecutive unselected AML patients treated with repeated courses of HDAC, with the addition of idarubicin, followed by autologous peripheral blood stem cell (PBSC) support, in order to limit toxicity, according to Northern Italy Leukemia Group (NILG) AML-01/00 study (EUDRACT number 00400673). Among 338 patients consecutively diagnosed from 2001 to 2017 at our center, 148 with high-risk AML (adverse cytogenetic, isolated FLT3-internal tandem duplication mutation, refractory to first induction) were addressed to allogeneic stem cell transplant. All other cases, 186 patients (55%), median age 53 (range 19–75), were considered standard-risk and received the NILG AML-01/00 program. After achieving CR, patients were mobilized with cytarabine 8 g/sqm to collect autologous CD34+-PBSC and received three consolidation cycles with HDAC (20 g/sqm) plus idarubicin (20 mg/sqm) per cycle, followed by reinfusion of limited doses of CD34+ PBSC (1-2x106/kg). The program was completed by 160 (86%) patients. Toxicity was acceptable. Neutrophils recovered a median of 10 days. Treatment-related mortality was 3/160 (1.8%). After a median follow-up of 66.4 months, overall survival (OS) and relapse-free survival (RFS) at 5-years were 61.4% and 52.4%, respectively. Twenty-eight selected patients aged >65 had similar outcomes. According to European leukemia net-2010 classification, the OS and RFS at 5-years were 76.4% and 65% in favorable risk, without differences between molecular subgroups, 52.3% and 47.2% in Intermediate-I, 45.2% and 36.5% in Intermediate-II risk patients, respectively. In conclusion, consolidation including repeated courses of high dose cytarabine and idarubicin, with limited PBSC support, proved feasible and very effective in nonhigh risk patients. The incorporation of novel agents in its backbone may be tested to further improve patient's prognosis. 相似文献
72.
73.
Maria?Concetta?FargnoliEmail author Gianfranco?Altomare Elisa?Benati Francesco?Borgia Paolo?Broganelli Anna?Carbone Sergio?Chimenti Sergio?Donato Giampiero?Girolomoni Giuseppe?Micali Erica?Moggio Aurora?Parodi Stefano?Piaserico Giuseppe?Pistone Concetta?Potenza Mario?Puviani Margherita?Raucci Sabina?Vaccari Stefano?Veglio Andrea?Zanca Ketty?Peris 《European journal of dermatology : EJD》2017,27(6):599-608
Background
Actinic keratosis (AK) is a common keratinocyte intraepidermal neoplasia.Objective
To assess AK prevalence and potential risk factors in patients attending Italian general dermatology clinics.Materials & methods
This retrospective study was conducted on clinical data from consecutive white outpatients aged ≥30 years, attending 24 general dermatology clinics between December 2014 and February 2015. AK prevalence (entire population) and multivariate risk factor analysis (patients with current/previous AK and complete data) are presented.Results
AK prevalence in 7,284 patients was 27.4% (95% CI: 26.4-28.4%); 34.3% in men and 20.0% in women (p<0.001). Independent AK risk factors in 4,604 patients were: age (OR: 4.8 [95% CI: 3.5-6.5] for 46-60 years, increasing with older age to OR: 41.5 [95% CI: 29.5-58.2] for >70 years), history of other non-melanoma skin cancers (OR: 2.7 [2.2-3.3]), residence in southern Italy/Sardinia (OR: 2.6 [2.1-3.0]), working outdoors >6 hours/day (OR: 1.9 [1.4-2.4]), male gender (OR: 1.7 [1.4-2.0]), facial solar lentigos (OR: 1.6 [1.4-1.9]), light hair colour (OR: 1.5 [1.2-1.8]), prolonged outdoor recreational activities (OR: 1.4 [1.2-1.7]), light eye colour (OR: 1.3 [1.1-1.6]), skin type I/II (OR: 1.3 [1.1-1.6]), and alcohol consumption (OR: 1.2 [1.0-3.3]). BMI ≥25.0 (OR: 0.6 [0.5-0.7]), regular sunscreen use (OR: 0.7 [0.6-0.8]), and a lower level of education (OR: 0.8 [0.7-1.0]) were independent protective factors.Conclusions
AK prevalence was high in Italian dermatology outpatients. We confirm several well-known AK risk factors and reveal possible novel risk and protective factors. Our results may inform on the design and implementation of AK screening and educational programmes.74.
Crispino P Pica R Angelucci E Consolazio A Rivera M Cassieri C Paoluzi P 《International journal of colorectal disease》2007,22(5):553-558
Several forms of primary and secondary hematological malignancies were rarely observed during the clinical course of inflammatory
bowel diseases (IBD). Patients needing a prolonged treatment with immunosuppressants, such as azathioprine or methotrexate,
with familiarity and genetic predisposition seem to be at a higher risk of leukemia. On the other hand, asthenia, thickness,
and fever may be the symptoms of the onset of each kind of hematological malignancy. The finding of anemia, alteration of
leukocyte count and large undetermined cells may suggest increased probability of abnormal proliferation of a single white
blood cell line. In this report, the occurrence of hematological malignancies is described in five patients affected by IBD
(three with ulcerative colitis and two with Crohn’s disease) attending our Gastroenterology Unit. 相似文献
75.
Coppola A Coppola L Luongo C Arciello A Cacciapuoti F Lama D Luongo M Ruggiero L Pastore A Gombos G 《The International journal of angiology》2007,16(1):7-11
Ozonized autohemotransfusion has been used as a complementary therapy in patients with peripheral arterial disease (PAD). To determine whether ozone therapy could acutely modify artery vasodilatory capacity, a flow-mediated dilation test was performed at the brachial artery level before and after an ozonized autohemotransfusion in 16 patients with PAD, mean (± SD) age 55±1.8 years, and 14 healthy volunteers matched for age, sex and body mass index. Before ozonized autohemotransfusion, the mean baseline diameter of the brachial artery was higher in PAD patients than in healthy subjects (4.6±0.54 mm versus 3.6±0.54 mm, P<0.001) while mean flow-mediated brachial artery dilation and percentage of increase in flow were significantly lower in PAD patients than in controls (6.3±6.1% versus 11.8±2.4%, P<0.02; 433±61% versus 580±46%, P<0.02, respectively). No significant changes were observed after ozonized autohemotransfusion, indicating that ozonized autohemotransfusion does not modify endothelium-dependent ischemia-induced vascular reactivity. 相似文献
76.
Sergio Daga Jie Ding Constantinos Deltas Judy Savige Beata S. Lipska-Zitkiewicz Julia Hoefele Frances Flinter Daniel P. Gale Marina Aksenova Hirofumi Kai Laura Perin Moumita Barua Roser Torra Jeff H. Miner Laura Massella Danica Galei Ljubanovi Rachel Lennon Andr B. Weinstock Bertrand Knebelmann Agne Cerkauskaite Susie Gear Oliver Gross A. Neil Turner Margherita Baldassarri Anna Maria Pinto Alessandra Renieri 《European journal of human genetics : EJHG》2022,30(5):507
77.
78.
79.
Conchedda M Seu V Capra S Caredda A Pani SP Lochi PG Collu C Mura A Gabriele F 《Acta tropica》2012,122(1):52-58
The epidemiological status of cystic echinococcosis (CE) in sheep in Sardinia over the 20 years since the last control attempt at the end of the 1980s has been assessed, comparing the results of two surveys carried out in abattoirs in southern Sardinia. In the first, conducted in 1995-1997 (5-7 years after the last control effort), CE prevalence of about 75% was observed in the 1375 sheep sampled, with intensity of 10.0 and mean abundance of 7.5. The most affected organ was the liver, whereas a large percentage of infected animals presented cysts in both the liver and lung. Overall, about 26% of parasitized sheep were found to be heavily infected and 12.15% of infected animals harboured fertile cysts. In the second survey, carried out ten years after the first, during the period 2005-2010 in absence of specific control measures, a total of 1414 sheep were examined. CE prevalence was 65%, 78% in the most rural Oristano province and 58% in the most "urbanised" province of Cagliari. Frequency of sheep infected in both the liver and lung had decreased slightly compared to the first survey, particularly in the Cagliari province, as had intensity and mean abundance, though to a lesser extent in the Oristano province. 14.6% of parasitized sheep were heavily infected, showing a general decline over the 10 years between the two surveys, particularly in the Cagliari area where the figure had more than halved. Conversely, about 14% of infected sheep hosted at least 1 fertile cyst, a slight increase compared to the 1st survey. Finally, the trend of CE transmission in Sardinian sheep according to surveys carried out from 1952 to 2010 has been analysed and the results are discussed in the light of the significant socio-economic and structural transformations that have actually modified the zoonosis scenario on the island. 相似文献
80.
Resistance of Congenitally Immunodeficient Gnotobiotic Mice to Vaginal Candidiasis 总被引:5,自引:2,他引:5 下载免费PDF全文
Congenitally immunodeficient beige, athymic, and beige athymic mice whose orogastric mucosal tissues were chronically colonized and infected with a pure culture of Candida albicans were found to be resistant to naturally occurring vulvovaginal candidiasis. 相似文献