Avidity of antibodies in sle

The avidity of antibodies to DNA in the sera of 8 patients with SLE was determined by saturation analysis and Scatchard plots. Five of the patients had severe lupus nephritis; the other 3 had relatively mild or no kidney disease. The Scatchard plots revealed components with high relative avidity in the patients with severe nephritis (K values 4.4–10.4 x 10⁵ M⁻¹ for nDNA), compared with the patients who had mild or no kidney disease (K values 0.3–1.8 x 10⁵ M⁻¹ for nDNA). Avidity measurements may be helpful in the evaluation and treatment of patients with SLE.     

Exploring physicians,nurses and ward-based pharmacists working relationships in a Swedish inpatient setting: a mixed methods study

International Journal of Clinical Pharmacy - Background In Sweden there has been limited work investigating the integration and nature of collaborative relationships between pharmacists and other...     

Bullous Melanoma: should the thickness of the bullous lesion be included in Breslow depth measurement?

Bullous melanoma represents a rare variant of melanoma, especially in patients without underlying bullous cutaneous disease. Few cases have been described in the literature, including cases of melanoma in patients with bullous epidermolysis or Hailey-Hailey disease. The histopathological diagnosis of bullous melanoma does not show any difficulties, except for the measurement of the Breslow index. The rarity of this case, the dilemma of how to measure the Breslow index and the importance of an early diagnosis motivated this report.