全文获取类型
收费全文 | 758篇 |
免费 | 52篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 17篇 |
妇产科学 | 5篇 |
基础医学 | 82篇 |
口腔科学 | 10篇 |
临床医学 | 76篇 |
内科学 | 286篇 |
皮肤病学 | 6篇 |
神经病学 | 33篇 |
特种医学 | 9篇 |
外科学 | 31篇 |
综合类 | 2篇 |
预防医学 | 139篇 |
眼科学 | 3篇 |
药学 | 44篇 |
肿瘤学 | 67篇 |
出版年
2023年 | 1篇 |
2022年 | 9篇 |
2021年 | 16篇 |
2020年 | 9篇 |
2019年 | 11篇 |
2018年 | 16篇 |
2017年 | 21篇 |
2016年 | 15篇 |
2015年 | 21篇 |
2014年 | 42篇 |
2013年 | 28篇 |
2012年 | 52篇 |
2011年 | 53篇 |
2010年 | 26篇 |
2009年 | 24篇 |
2008年 | 48篇 |
2007年 | 71篇 |
2006年 | 51篇 |
2005年 | 47篇 |
2004年 | 41篇 |
2003年 | 38篇 |
2002年 | 34篇 |
2001年 | 18篇 |
2000年 | 15篇 |
1999年 | 16篇 |
1998年 | 5篇 |
1997年 | 14篇 |
1996年 | 6篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 5篇 |
1992年 | 4篇 |
1991年 | 9篇 |
1990年 | 9篇 |
1989年 | 11篇 |
1988年 | 5篇 |
1987年 | 8篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 2篇 |
排序方式: 共有811条查询结果,搜索用时 140 毫秒
81.
82.
Objective
The paper presents an application of the “Fit between Individuals, Task and Technology” (FITT) framework to analyze the socio-organizational-technical factors that influence IT adoption in the healthcare domain.Method
The FITT framework was employed as the theoretical instrument for a retrospective analysis of a 15-year effort in implementing IT systems and eHealth services in the context of a Regional Health Information Network in Crete. Quantitative and qualitative research methods, interviews and participant observations were employed to gather data from a case study that involved the entire region of Crete.Results
The detailed analysis of the case study based on the FITT framework, showed common features, but also differences of IT adoption within the various health organizations. The emerging picture is a complex nexus of factors contributing to IT adoption, and multi-level interventional strategies to promote IT use.Conclusion
The work presented in this paper shows the applicability of the FITT framework in explaining the complexity of aspects observed in the implementation of healthcare information systems. The reported experiences reveal that fit management can be viewed as a system with a feedback loop that is never really stable, but ever changing based on external factors or deliberate interventions. Management of fit, therefore, becomes a constant and complex task for the whole life cycle of IT systems. 相似文献83.
84.
Vavuranakis M Latsios G Tousoulis D Vaina S Triantafyllou G Drakopoulou M Stefanadis C 《International journal of cardiology》2007,118(1):e24-e26
An unusual case of giant hydatic cyst of the left ventricle producing cardiac and systemic symptomatology is described. The patient had suffered presyncopal and syncopal attacks and the final diagnosis was made by combination of echocardiography, magnetic resonance imaging and serological tests. Surgical resection of the cyst supplemented by medical therapy yielded favorable results. 相似文献
85.
Stefanadis C Toutouzas K Tsiamis E Vavuranakis M Tsioufis C Stefanadi E Boudoulas H 《Atherosclerosis》2007,192(2):396-400
Although previous studies have shown systemic inflammatory activation the relation with the local plaque inflammatory activation has not been extensively studied. The present study investigated the relation between local and systemic inflammatory activation in patients with coronary artery disease and the impact of atorvastatin treatment. We included 215 patients undergoing percutaneous coronary intervention; of them 140 were treated with atorvastatin. Patients with stable angina (SA) and acute coronary syndromes (ACS) were included. Systemic inflammation was assessed by serum C-reactive protein (CRP), soluble adhesion molecules levels and local plaque inflammatory activation by coronary thermography. Temperature difference (DeltaT) was assigned as the difference between the proximal vessel wall temperature from the maximal temperature at the culprit plaque. Patients with ACS (n=78) had increased DeltaT compared to patients with SA (n=137) (0.16+/-0.10 degrees C versus 0.08+/-0.07 degrees C, P<0.001). Patients treated with atorvastatin had lower DeltaT compared to untreated patients (0.10+/-0.07 degrees C versus 0.15+/-0.10 degrees C, P<0.01). DeltaT was less in the treated group compared to the untreated group in patients with SA and ACS (ACS: 0.13+/-0.08 degrees C versus 0.20+/-0.11 degrees C, P<0.01, SA: 0.08+/-0.06 degrees C versus 0.13+/-0.08 degrees C, P=0.03). Although a correlation was found between CRP levels and DeltaT (R=0.29, P<0.01), in certain groups a discrepancy between CRP levels and DeltaT was observed. In 25% of patients with low DeltaT CRP levels were >1mg/dl and in 35.5% of patients with high DeltaT CRP was <2mg/dl. The correlation between soluble adhesion molecules and DeltaT did not reach statistical significance. Although there is a correlation between widespread and local inflammatory activation in patients with coronary artery disease, a discrepancy between culprit plaque and systemic inflammatory activation is observed. Atorvastatin has a parallel effect on systemic and local inflammatory process in patients with coronary artery disease. 相似文献
86.
Systematic discovery of regulatory motifs in conserved regions of the human genome, including thousands of CTCF insulator sites 总被引:12,自引:0,他引:12
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Xie X Mikkelsen TS Gnirke A Lindblad-Toh K Kellis M Lander ES 《Proceedings of the National Academy of Sciences of the United States of America》2007,104(17):7145-7150
Conserved noncoding elements (CNEs) constitute the majority of sequences under purifying selection in the human genome, yet their function remains largely unknown. Experimental evidence suggests that many of these elements play regulatory roles, but little is known about regulatory motifs contained within them. Here we describe a systematic approach to discover and characterize regulatory motifs within mammalian CNEs by searching for long motifs (12-22 nt) with significant enrichment in CNEs and studying their biochemical and genomic properties. Our analysis identifies 233 long motifs (LMs), matching a total of approximately 60,000 conserved instances across the human genome. These motifs include 16 previously known regulatory elements, such as the histone 3'-UTR motif and the neuron-restrictive silencer element, as well as striking examples of novel functional elements. The most highly enriched motif (LM1) corresponds to the X-box motif known from yeast and nematode. We show that it is bound by the RFX1 protein and identify thousands of conserved motif instances, suggesting a broad role for the RFX family in gene regulation. A second group of motifs (LM2*) does not match any previously known motif. We demonstrate by biochemical and computational methods that it defines a binding site for the CTCF protein, which is involved in insulator function to limit the spread of gene activation. We identify nearly 15,000 conserved sites that likely serve as insulators, and we show that nearby genes separated by predicted CTCF sites show markedly reduced correlation in gene expression. These sites may thus partition the human genome into domains of expression. 相似文献
87.
88.
The use of spray electrocautery to control presacral bleeding: a report of four cases 总被引:1,自引:0,他引:1
Filippakis GM Leandros M Albanopoulos K Genetzakis M Lagoudianakis E Pararas N Konstandoulakis MM 《The American surgeon》2007,73(4):410-413
Bleeding originating from the presacral venous plexus during pelvic operations is difficult to control, constituting a potentially life-threatening complication. Although suture ligatures, packing, and placement of tacks are established hemostatic techniques, they are often proved to be ineffective. We report a simple novel technique using spray diathermy for managing this severe complication. We have applied our method in four patients, two undergoing low anterior resection, and the others undergoing abdominoperineal resection for rectal cancer, that manifested severe presacral bleeding during rectal mobilization. Electrocautery at spray setting was applied slightly above the target bleeders at the presacral fascia, delivering a high-frequency electrical current in combination with drainage suction. In all cases, the method resulted in successful hemostasis. Applying spray electrocautery is a simple and effective method for controlling presacral bleeding. The advantages of using such a method instead of conventional hemostatic techniques include the option of varying the degree of haemostatic effect by altering the frequency and the volume of electric current. 相似文献
89.
90.
Clifford P. Weisel Susan D. Richardson Benoit Nemery Gabriella Aggazzotti Eugenio Baraldi Ernest R. Blatchley III Benjamin C. Blount Kai-H?kon Carlsen Peyton A. Eggleston Fritz H. Frimmel Michael Goodman Gilbert Gordon Sergey A. Grinshpun Dirk Heederik Manolis Kogevinas Judy S. LaKind Mark J. Nieuwenhuijsen Fontaine C. Piper Syed A. Sattar 《Environmental health perspectives》2009,117(4):500-507