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271.
Manikandan R Srirangam SJ Brown SC O'Reilly PH Collins GN 《The Journal of urology》2003,170(5):1881-3; discussion 1883
PURPOSE: We compared the efficacy of Entonox (BOC Gases, Manchester, United Kingdom), a mixture of 50% nitrous oxide and oxygen, with periprostatic infiltration of 1% lidocaine to provide analgesia during transrectal ultrasound (TRUS) guided biopsy of the prostate. MATERIALS AND METHODS: The study included 235 consecutive men undergoing TRUS guided biopsy of the prostate for elevated prostate specific antigen or abnormal digital rectal examination. Patients were randomized to 3 groups, including group 1-84 controls who did not receive any form of analgesia prior to the procedure, group 2-75 who received periprostatic infiltration with 10 ml 1% lidocaine with biopsies performed 5 minutes after infiltration and group 3-76 who received Entonox for 2 minutes through a breath activated device prior to the procedure and thereafter according to patient preference. All patients were asked to indicate the level of pain experienced before and after the procedure on a 10 cm, nonnumerical, horizontal visual analog score. Results were analyzed using 1-way ANOVA. RESULTS: Mean patient age was 68.8, 64.9 and 65.2 years, and mean visual analog score was 2.9, 1.6 and 2.2 in groups 1 to 3, respectively. Patients in groups 2 (1% lidocaine infiltration) and 3 (Entonox) experienced significantly less pain during the procedure compared with group 1 controls (p <0.001 and 0.028, respectively). There was no statistical difference in pain scores between groups 2 and 3 (p = 0.08). CONCLUSIONS: Inhalation of Entonox or periprostatic infiltration with 1% lidocaine can be used for analgesia during TRUS guided biopsy of the prostate since each provides significant and similar pain relief. 相似文献
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273.
V. Manikandan Iulian Petrila S. Vigneselvan R. S. Mane Bogdan Vasile Raghu Dharmavarapu Stefan Lundgaard Saulius Juodkazis J. Chandrasekaran 《RSC advances》2020,10(7):3796
Herein, we report the chemiresistive gas and humidity sensing properties of pristine and nickel-doped tin oxide (Ni-SnO2) gas sensors prepared by a microwave-assisted wet chemical method. The structural and optical properties are characterised using X-ray diffraction, scanning electron microscopy, scanning transmission electron microscopy, ultraviolet spectroscopy, Fourier transform infrared spectroscopy, and X-ray photoelectron spectroscopy. The structural elucidation and morphology analyses confirm a particle size of 32–46 nm, tetragonal rutile crystal structure and small cauliflower-type surface appearance. Nickel doping can tune the structure of NPs and morphology. The tested carbon dioxide gas and humidity sensing properties reveal a rapid sensing performance with high-to-moderate sensitivity. Also, the materials favour gas sensing because their sensitivity is enhanced with the increase in nickel concentration. The sensing results suggest that nickel is a vibrant metal additive to increase the gas sensitivity of the sensor. However, nickel doping decreases the electron density and increases the oxygen vacancies. Ultimately, the gas sensor produces highly rapid sensing with a response time of 4 s.Herein, we report the chemiresistive gas and humidity sensing properties of pristine and nickel-doped tin oxide (Ni-SnO2) gas sensors prepared by a microwave-assisted wet chemical method. 相似文献
274.
Reitze N. Rodseth Bruce M. Biccard Yannick Le Manach Daniel I. Sessler Giovana A. Lurati Buse Lehana Thabane Robert C. Schutt Daniel Bolliger Lucio Cagini Daniela Cardinale Carol P.W. Chong Rong Chu Miłosław Cnotliwy Salvatore Di Somma René Fahrner Wen Kwang Lim Elisabeth Mahla Ramaswamy Manikandan Francesco Puma Wook B. Pyun Milan Radović Sriram Rajagopalan Stuart Suttie Thuvaraha Vanniyasingam William J. van Gaal Marek Waliszek P.J. Devereaux 《Journal of the American College of Cardiology》2014
275.
Prasanth Ganesan Tenali Gnana Sagar Krishnarathinam Kannan Venkatraman Radhakrishnan Manikandan Dhanushkodi Rajaraman Swaminathan Shirley Sundersingh Trivadi S. Ganesan 《Indian journal of hematology & blood transfusion》2018,34(3):422-429
Young adults with acute lymphoblastic leukemia do better when treated on “pediatric” protocols. Young adults (18–30 years) with Ph-negative ALL treated between 2000 and 2014 were retrospectively analyzed. Two-hundred and thirty-two patients were included [median age 21 years (18–30); 176 (76%) males; median WBC 16,000/cmm]. Protocols used were: BFM 95 (N = 147, 63%), MCP-841 (N = 51, 22%), GMALL (N = 21, 9%), INCTR (N = 9, 4%) and UKALL (N = 4, 2%). Complete remission was achieved in 194/232 (84%). Twenty patients (9%) died due to toxicity which was higher with BFM versus others (18/147 vs. 2/85; p = 0.031). After a median follow-up of 48 months, median RFS and OS were 35.5 months (25–46), and 25 months (18–31) and actuarial RFS and OS (5-years) were 45% (37–53) and 39% (32–46). BFM protocol improved RFS (51 vs. 35%, p = 0.027) but not OS (43 vs. 33%, p = 0.2). The survival outcomes reported are 15–20% lower than those reported from West. Better supportive care and risk-adapted therapy may improve outcomes. 相似文献
276.
277.
Anjali Sivaramakrishnan John M. Solomon Natarajan Manikandan 《The journal of spinal cord medicine》2018,41(4):397-406
Objective: Spasticity following spinal cord injury (SCI) can impair function and affect quality of life. This study compared the effects of transcutaneous electrical nerve stimulation (TENS) and functional electrical stimulation (FES) on lower limb spasticity in patients with SCI.Design: Double blind randomized crossover design.Setting: Neuro-rehabilitation unit, Manipal University, India.Participants: Ten participants (age: 39 ± 13.6 years, C1–T11, 1–26 months post SCI) with lower limb spasticity were enrolled in this study.Interventions: Participants were administered electrical stimulation with TENS and FES (duration - 30 minutes) in a cross over manner separated by 24 hours.Outcome Measures: Spasticity was measured using modified Ashworth scale (MAS) [for hip abductors, knee extensors and ankle plantar flexors] and spinal cord assessment tool for spastic reflexes (SCATS). Assessments were performed at baseline, immediately, 1 hour, 4 hours, and 24 hours post intervention.Results: A between group analysis did not show statistically significant differences between FES and TENS (P > 0.05). In the within group analyses, TENS and FES significantly reduced spasticity up to 4 hours in hip adductors and knee extensors (P < 0.01). SCATS values showed significant reductions at 1 hour (P?=?0.01) following TENS and 4 hours following FES (P?=?0.01).Conclusion: A single session of electrical stimulation with FES and TENS appears to have similar anti-spasticity effects that last for 4 hours. The findings of this preliminary study suggest that both TENS and FES have the potential to be used as therapeutic adjuncts to relieve spasticity in the clinic. In addition, FES may have better effects on patients presenting with spastic reflexes. 相似文献
278.
279.
Abhiram Charan Tej Mallu Sivapriya Sivagurunathan Debasish Paul Hobby Aggarwal Abel Arul Nathan Amrutha Manikandan Mahalakshmi M. Ravi Ramanamurthy Boppana Kumaravelu Jagavelu Manas Kumar Santra Madhulika Dixit 《Immunology》2023,170(1):60-82
Nutritional availability during fasting and refeeding affects the temporal redistribution of lymphoid and myeloid immune cells among the circulating and tissue-resident pools. Conversely, nutritional imbalance and impaired glucose metabolism are associated with chronic inflammation, aberrant immunity and anomalous leukocyte trafficking. Despite being exposed to periodic alterations in blood insulin levels upon fasting and feeding, studies exploring the physiological effects of these hormonal changes on quiescent immune cell function and trafficking are scanty. Here, we report that oral glucose load in mice and healthy men enhances the adherence of circulating peripheral blood mononuclear cells (PBMCs) and lymphocytes to fibronectin. Adherence to fibronectin is also observed upon regular intake of breakfast following overnight fasting in healthy subjects. This glucose load-induced phenomenon is abrogated in streptozotocin-injected mice that lack insulin. Intra-vital microscopy in mice demonstrated that oral glucose feeding enhances the homing of PBMCs to injured blood vessels in vivo. Furthermore, employing flow cytometry, Western blotting and adhesion assays for PBMCs and Jurkat-T cells, we elucidate that insulin enhances fibronectin adherence of quiescent lymphocytes through non-canonical signalling involving insulin-like growth factor-1 receptor (IGF-1R) autophosphorylation, phospholipase C gamma-1 (PLCγ-1) Tyr783 phosphorylation and inside-out activation of β-integrins respectively. Our findings uncover the physiological relevance of post-prandial insulin spikes in regulating the adherence and trafficking of circulating quiescent T-cells through fibronectin–integrin interaction. 相似文献