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Anand Gaikwad Ashish Gupta Sam Hare Marcio Gomes Harman Sekhon Carolina Souza Joao Inacio Shilpa Lad Jean Seely 《European journal of radiology》2012
Primary adenocarcinoma of lung has replaced squamous cell carcinoma as the commonest histological subtype of lung cancer and the incidence of primary lung adenocarcinoma appears to be rising. Although the main factors behind this ‘epidemic-like’ situation are largely undiscovered, filter cigarettes appear to significantly contribute to this shift in the histopathological spectrum. The new multidisciplinary classification of adenocarcinoma of lung was introduced to address advances in clinical, pathological, radiological and molecular sciences. The purpose of this essay is to discuss various classes of lung adenocarcinoma in the new classification with their classical imaging features on computed tomography and summarise the recent advances in the field of radiology and review radiology recommendations. 相似文献
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Maria C.S. Inacio Donna Kritz-Silverstein Rema Raman Caroline A. Macera Jeanne F. Nichols Richard A. Shaffer Donald C. Fithian 《The Journal of arthroplasty》2014
This study characterized a cohort of obese total hip arthroplasty (THA) and total knee arthroplasty (TKA) patients (1/1/2008–12/31/2010) and evaluated whether a clinically significant amount of pre-operative weight loss (5% decrease in body weight) is associated with a decreased risk of surgical site infections (SSI) and readmissions post-surgery. 10,718 TKAs and 4066 THAs were identified. During the one year pre-TKA 7.6% of patients gained weight, 12.4% lost weight, and 79.9% remained the same. In the one year pre-THA, 6.3% of patients gained weight, 18.0% lost weight, and 75.7% remained the same. In TKAs and THAs, after adjusting for covariates, the risk of SSI and readmission was not significantly different in the patients who gained or lost weight pre-operatively compared to those who remained the same. 相似文献
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Namba RS Inacio MC Paxton EW Robertsson O Graves SE 《The Journal of bone and joint surgery. American volume》2011,93(Z3):48-50
The conventional wisdom that a mobile-bearing design may offer a benefit compared with a fixed-bearing design in total knee arthroplasty has not been supported by evidence. We reviewed the published literature and annual registry reports of all national and regional registries to determine the differences in clinical outcomes between mobile and fixed-bearing designs. We found only single-center reports and studies with small sample sizes in the published literature. These studies did not demonstrate any advantages of mobile bearings over fixed bearings. Moreover, major national joint registries reported higher failure rates associated with mobile-bearing total knee replacement compared with fixed-bearing total knee replacement. Similar findings from a U.S. national study in a community setting suggest that mobile-bearing knees have an increased risk of revision. After harmonization of methodologies, international collaborations of registries may provide the best insight into the performance of mobile-bearing total knee arthroplasty in real-world settings. 相似文献
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Bassat Q Machevo S O'Callaghan-Gordo C Sigaúque B Morais L Díez-Padrisa N Ribó JL Mandomando I Nhampossa T Ayala E Sanz S Weber M Roca A Alonso PL 《The American journal of tropical medicine and hygiene》2011,85(4):626-634
Malaria and severe pneumonia in hospitalized young children may show striking clinical similarities, making differential diagnosis challenging. We investigated ways to increase diagnostic accuracy in patients hospitalized with clinical symptoms compatible with malaria and severe pneumonia, in an area with high a prevalence of infection with human immunodeficiency virus. A total of 646 children admitted at the Manhiça District Hospital in Manhiça, Mozambique who met the World Health Organization clinical criteria for severe pneumonia and malaria were recruited for 12 months and thoroughly investigated to ascertain an accurate diagnosis. Although symptom overlap between malaria and severe pneumonia was frequent among hospitalized children, true disease overlap was uncommon. Clinical presentation and laboratory determinations were ineffective in reliably distinguishing between the two diseases. Infection with human immunodeficiency virus differentially influenced the epidemiology and clinical presentation of these two infectious diseases, further challenging their discrimination on clinical grounds, and having a greater impact on the current burden and prognosis of severe pneumonia. 相似文献
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Carlota Doba?o Diana Quelhas Lloren? Quintó Laura Puyol Elisa Serra-Casas Alfredo Mayor Tacilta Nhampossa Eusebio Macete Pedro Aide Inacio Mandomando Sergi Sanz Sanjeev K. Puniya Bijender Singh Puneet Gupta Arindam Bhattacharya Virander S. Chauhan John J. Aponte Chetan E. Chitnis Pedro L. Alonso Clara Menéndez 《Clinical and Vaccine Immunology : CVI》2012,19(2):157-166
Plasmodium falciparum blood-stage antigens such as merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and the 175-kDa erythrocyte binding antigen (EBA-175) are considered important targets of naturally acquired immunity to malaria. However, it is not clear whether antibodies to these antigens are effectors in protection against clinical disease or mere markers of exposure. In the context of a randomized, placebo-controlled trial of intermittent preventive treatment in infants conducted between 2002 and 2004, antibody responses to Plasmodium falciparum blood-stage antigens in a cohort of 302 Mozambican children were evaluated by immunofluorescence antibody test and enzyme-linked immunosorbent assay at 5, 9, 12, and 24 months of age. We found that IgG subclass responses to EBA-175 were differentially associated with the incidence of malaria in the follow-up period. A double amount of cytophilic IgG1 or IgG3 was associated with a significant decrease in the incidence of malaria (incidence rate ratio [IRR] = 0.49, 95% confidence interval [CI] = 0.25 to 0.97, and P = 0.026 and IRR = 0.44, CI = 0.19 to 0.98, and P = 0.037, respectively), while a double amount of noncytophilic IgG4 was significantly correlated with an increased incidence of malaria (IRR = 3.07, CI = 1.08 to 8.78, P = 0.020). No significant associations between antibodies to the 19-kDa fragment of MSP-1 (MSP-119) or AMA-1 and incidence of malaria were found. Age, previous episodes of malaria, present infection, and neighborhood of residence were the main factors influencing levels of antibodies to all merozoite antigens. Deeper understanding of the acquisition of antibodies against vaccine target antigens in early infancy is crucial for the rational development and deployment of malaria control tools in this vulnerable population. 相似文献
60.
Yungher DA Morgia J Bair WN Inacio M Beamer BA Prettyman MG Rogers MW 《Clinical biomechanics (Bristol, Avon)》2012,27(2):151-157