全文获取类型
收费全文 | 194994篇 |
免费 | 1944篇 |
国内免费 | 92篇 |
专业分类
耳鼻咽喉 | 1256篇 |
儿科学 | 6931篇 |
妇产科学 | 3229篇 |
基础医学 | 18780篇 |
口腔科学 | 2132篇 |
临床医学 | 13605篇 |
内科学 | 35515篇 |
皮肤病学 | 1023篇 |
神经病学 | 17976篇 |
特种医学 | 9854篇 |
外科学 | 32292篇 |
综合类 | 2399篇 |
一般理论 | 1篇 |
预防医学 | 18764篇 |
眼科学 | 3234篇 |
药学 | 10941篇 |
中国医学 | 647篇 |
肿瘤学 | 18451篇 |
出版年
2022年 | 164篇 |
2021年 | 353篇 |
2020年 | 224篇 |
2019年 | 294篇 |
2018年 | 22201篇 |
2017年 | 17569篇 |
2016年 | 19755篇 |
2015年 | 1217篇 |
2014年 | 1179篇 |
2013年 | 1304篇 |
2012年 | 7763篇 |
2011年 | 21894篇 |
2010年 | 19298篇 |
2009年 | 11919篇 |
2008年 | 20256篇 |
2007年 | 22535篇 |
2006年 | 1514篇 |
2005年 | 3086篇 |
2004年 | 4249篇 |
2003年 | 5103篇 |
2002年 | 3305篇 |
2001年 | 1147篇 |
2000年 | 1304篇 |
1999年 | 922篇 |
1998年 | 471篇 |
1997年 | 407篇 |
1996年 | 312篇 |
1995年 | 243篇 |
1994年 | 241篇 |
1993年 | 181篇 |
1992年 | 560篇 |
1991年 | 569篇 |
1990年 | 597篇 |
1989年 | 540篇 |
1988年 | 460篇 |
1987年 | 442篇 |
1986年 | 428篇 |
1985年 | 417篇 |
1984年 | 249篇 |
1983年 | 203篇 |
1982年 | 113篇 |
1980年 | 97篇 |
1979年 | 181篇 |
1978年 | 118篇 |
1977年 | 105篇 |
1974年 | 97篇 |
1973年 | 96篇 |
1970年 | 128篇 |
1969年 | 111篇 |
1968年 | 102篇 |
排序方式: 共有10000条查询结果,搜索用时 609 毫秒
31.
32.
Debra L. Roter Richard M. Frankel Judith A. Hall David Sluyter 《Journal of general internal medicine》2006,21(1):28-34
Relationship-centered care reflects both knowing and feeling: the knowledge that physician and patient bring from their respective domains of expertise, and the physician’s and patient’s experience, expression, and perception of emotions during the medical encounter. These processes are conveyed and reciprocated in the care process through verbal and nonverbal communication. We suggest that the emotional context of care is especially related to nonverbal communication and that emotion-related communication skills, including sending and receiving nonverbal messages and emotional self-awareness, are critical elements of high-quality care. Although nonverbal behavior has received far less study than other care processes, the current review argues that it holds significance for the therapeutic relationship and influences important outcomes including satisfaction, adherence, and clinical outcomes of care. 相似文献
33.
杨娅 Thomas Bartel Loredana Latina Guido Caspari 王新房 Raimund Erbel 《华中科技大学学报(医学英德文版)》2002,22(2):158-163
Coronary flow reserve (CFR) has been used toassess coronary microcirculation and epicardial coro-nary stenoses[1— 3 ] . CFR is defined as the ratio ofcoronary flow under maximal coronary vasodilatationto coronary flow under resting conditions[4 ] .Whenthe cross- sectional area of epicardial coronary arteriesis constant,coronary flow velocity (CFV) ratios areequal to volume flow ratios.The most common method used clinically formeasuring CFVR is intracoronary Doppler flow(ICD) analysis re… 相似文献
34.
35.
36.
Hidetaro Mori Keisuke Hiraoka Ryoichi Yorifuji Tohru Iwasaki Syuzo Gomikawa Ohshi Inagaki Seishi Inoue Yoshihiro Takamitsu Yoshikazu Fujita 《Artificial organs》1994,18(10):725-728
Abstract: The adsorptive characteristics of 5 dialysis membranes for recombinant human erythropoietin (EPO) were studied in vitro in a closed circuit system. For 120 min, EPO added with bovine serum was significantly adsorbed by polymethylmetacrylate (PMMA) and polyacry–lonitrile (PAN) membranes but not by Cuprophan, ethylene vinyl alcohol (EVAL), or polysulfone (PS) membranes. In addition the EPO adsorptive rate, as well as that of β2 –microglobulin (β2 –MG), was greater with a PMMA membrane than with a PAN membrane. EPO was not detected in the ultrafiltrate at 15 min with 5 membranes. These results indicate that EPO was eliminated by membrane adsorption only with some dialysis membranes. 相似文献
37.
Y Nishizawa T Shoji S Tanaka M Yamashita A Morita M Emoto T Tabata T Inoue H Morii 《American journal of kidney diseases》1998,31(4):655-661
Leptin is a newly found hormone secreted by adipocytes that regulates food intake, thermogenesis, and body fat. We measured plasma leptin levels in 103 patients with chronic renal failure treated by hemodialysis and 167 age- and gender-matched healthy control subjects to examine the impact of renal failure on plasma leptin levels and the influence of leptin on body composition measured by dual-energy X-ray absorptiometry. Hemodialysis patients showed a significant decrease in both body fat mass and lean body mass compared with those of the control subjects. Plasma leptin was significantly elevated in the hemodialysis group over the controls. In both groups, leptin was higher in female than male subjects, and it correlated positively with percent body fat. The subjects were divided into six categories according to percent body fat, and plasma leptin levels were compared between the two groups in the same category. Leptin of hemodialysis patients was significantly higher than that of the control subjects in the percent body fat categories of 30 or greater, whereas there was no statistically significant difference in leptin concentrations in the lower percent body fat categories. This was also true in the comparison in each gender, and leptin levels in female subjects showed a more remarkable difference between the hemodialysis and control groups in obese categories. Multiple regression analysis in all subjects indicated that plasma leptin levels were independently affected by percent body fat, plasma insulin concentration, gender, and renal failure. The positive impact of renal failure on leptin remained significant in the subjects with percent body fat of 30 or greater in the multiple regression model, whereas it was no longer significant in the remaining lean subjects. In multiple regression analysis of factors affecting fat mass index and lean mass index, leptin level was selectively associated with fat mass index, but not with lean mass index, regardless of percent body fat ranges. These results indicate that renal failure is an important factor affecting plasma leptin levels, especially in obese female subjects, and that hyperleptinemia was closely related to fat mass but not to lean body mass in hemodialysis patients. 相似文献
38.
T Uno H Kondo Y Inoue Y Kawahata M Sotomura K Iuchi G Tsukamoto 《Journal of medicinal chemistry》1990,33(10):2929-2932
A series of novel pyridone carboxylic acids having a 4-hydroxypiperazinyl group at the 7-position of norfloxacin and ciprofloxacin were prepared. The in vivo antibacterial efficacies of these compounds were superior to those of corresponding piperazinyl derivatives. From the results of the studies on the pharmacokinetic profile and toxicity, the 4-hydroxypiperazinyl derivatives were confirmed to be pharmacologically superior to corresponding piperazinyl derivatives. Thus, a 4-hydroxypiperazinyl group was revealed to be a beneficial substituent for potential use in future quinolone antibacterials. 相似文献
39.
Irwin L. Flink 《Brain structure & function》2002,205(3):235-244
40.
Preoperative concurrent chemotherapy and radiation therapy followed by surgery for esophageal cancer. 总被引:1,自引:0,他引:1
Masahiko Yano Masatoshi Inoue Hitoshi Shiozaki 《Annals of thoracic and cardiovascular surgery》2002,8(3):123-130
Currently, the most promising strategy to improve the prognosis of advanced esophageal cancer is preoperative chemoradiation (CRT) followed by surgery. The superiority of CRT over radiation therapy alone has been demonstrated by several randomized studies. Many phase II studies of CRT followed by surgery have shown that the pathologic complete response (CR) rate ranges from 17 to 40%, and the median survival time (MST) is 12 to 31.3 months. Five randomized trials have compared preoperative CRT followed by surgery with surgery alone for resectable esophageal cancer, and four of them did not find any significant survival benefit for the combined treatment group. There are several issues in interpreting these findings, such as the quality of the surgery, the accuracy of the preoperative staging, the statistical power and design of the trials. Until comprehensive evaluation can be done, the standard therapy for resectable esophageal cancer should be considered to be surgery alone. The histological response in the resected specimen correlates well with the prognosis. Patients with pathologic CR display significantly better survival than those with microscopic residual cancer cells in the resected specimens. These findings suggest that more potent regimens leading to higher pathologic CR rates should improve the prognosis. Chemotherapy or radiation therapy sensitivity testing needs to be established. If accurate prediction of the response is possible prior to therapy, non-responders can be excluded. Cell cycle-related genes, apoptosis-related genes, and drug metabolizing genes have been investigated in many pilot studies and need to be evaluated by large-scale clinical studies. At present, pathologic CR can not be accurately diagnosed before surgery. Endoscopic biopsy is also unreliable for the diagnosis. In the future, new diagnostic tools such as positron emission tomography scanning, a sensitivity test or molecular markers may enable accurate diagnosis of pathologic CR to guide the choice of treatment strategies for individual patients. 相似文献