全文获取类型
收费全文 | 3191篇 |
免费 | 131篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 68篇 |
妇产科学 | 27篇 |
基础医学 | 472篇 |
口腔科学 | 39篇 |
临床医学 | 189篇 |
内科学 | 780篇 |
皮肤病学 | 87篇 |
神经病学 | 317篇 |
特种医学 | 54篇 |
外科学 | 562篇 |
综合类 | 19篇 |
预防医学 | 51篇 |
眼科学 | 15篇 |
药学 | 222篇 |
中国医学 | 3篇 |
肿瘤学 | 419篇 |
出版年
2023年 | 19篇 |
2022年 | 44篇 |
2021年 | 58篇 |
2020年 | 44篇 |
2019年 | 54篇 |
2018年 | 59篇 |
2017年 | 35篇 |
2016年 | 55篇 |
2015年 | 40篇 |
2014年 | 66篇 |
2013年 | 91篇 |
2012年 | 119篇 |
2011年 | 154篇 |
2010年 | 98篇 |
2009年 | 72篇 |
2008年 | 130篇 |
2007年 | 121篇 |
2006年 | 153篇 |
2005年 | 147篇 |
2004年 | 137篇 |
2003年 | 129篇 |
2002年 | 119篇 |
2001年 | 138篇 |
2000年 | 133篇 |
1999年 | 118篇 |
1998年 | 42篇 |
1997年 | 40篇 |
1996年 | 21篇 |
1995年 | 16篇 |
1994年 | 16篇 |
1993年 | 15篇 |
1992年 | 64篇 |
1991年 | 58篇 |
1990年 | 59篇 |
1989年 | 70篇 |
1988年 | 51篇 |
1987年 | 54篇 |
1986年 | 82篇 |
1985年 | 66篇 |
1984年 | 34篇 |
1983年 | 38篇 |
1982年 | 26篇 |
1981年 | 25篇 |
1980年 | 21篇 |
1979年 | 29篇 |
1978年 | 17篇 |
1977年 | 21篇 |
1970年 | 17篇 |
1969年 | 16篇 |
1968年 | 15篇 |
排序方式: 共有3335条查询结果,搜索用时 0 毫秒
91.
Hiroshi Okano Tatsunori Nakano Kazushi Sugimoto Kazuaki Takahashi Shigeo Nagashima Masaharu Takahashi Masahiro Arai Hiroaki Okamoto 《Hepatology research》2014,44(6):694-699
A 67‐year‐old male living in Tsu city, Mie prefecture, Japan was referred to our hospital for further examination of acute liver injury and was diagnosed as having clinical hepatitis E virus (HEV) infection in January 2010. The HEV strain (HE‐JA11‐1701) isolated from the patient belonged to genotype 3 and European‐type subgenotype 3e. It was presumed that the patient had been infected from a wild boar (Sus scrofa leucomystax) because he consumed meat/viscera from a wild boar that he had captured himself as a hunter approximately 2 months before disease onset. A specimen of the boar meat/viscera that the patient had ingested was not available. However, the HE‐JA11‐1701 strain was 99.8% identical within the 412‐nucleotide sequence of the open reading frame 2 region to a HEV strain (JBOAR012‐Mie08) that had been recovered from a wild boar captured near the patient's hunting area in 2008. A phylogenetic analysis confirmed that the two HEV strains had a close genetic relationship and were segregated into subgenotype 3e, supported by a high bootstrap value of 99%. Of note, the HE‐JA11‐1701 and JBOAR012‐Mie08 strains were remotely related to the 3e strains reported in Japan and European countries, with a nucleotide difference of 7.9–13.9%, reinforcing the uniqueness of the 3e strains obtained in the present study. These results strongly support our speculation that the patient developed acute hepatitis E via consumption of HEV‐infected boar meat/viscera. Genetic analyses of HEV strains are useful for tracing infectious sources in sporadic cases of acute hepatitis E. 相似文献
92.
Masashi Ninomiya Yasuteru Kondo Tetsuya Niihori Takeshi Nagashima Takayuki Kogure Eiji Kakazu Osamu Kimura Yoko Aoki Yoichi Matsubara Tooru Shimosegawa 《Hepatology research》2014,44(6):678-684
Taking nucleoside/nucleotide analogs is a major antiviral therapy for chronic hepatitis B infection. The problem with this treatment is the selection for drug‐resistant mutants. Currently, identification of genotypic drug resistance is conducted by molecular cloning sequenced by the Sanger method. However, this methodology is complicated and time‐consuming. These limitations can be overcome by deep sequencing technology. Therefore, we performed sequential analysis of the frequency of drug resistance in one individual, who was treated with lamivudine on‐and‐off therapy for 2 years, by deep sequencing. The lamivudine‐resistant mutations at rtL180M and rtM204V and the entecavir‐resistant mutation at rtT184L were detected in the first subject. The lamivudine‐ and entecavir‐resistant strain was still detected in the last subject. However, in the deep sequencing analysis, rt180 of the first subject showed a mixture in 76.9% of the methionine and in 23.1% of the leucine, and rt204 also showed a mixture in 69.0% of the valine and 29.8% of the isoleucine. During the treatment, the ratio of resistant mutations increased. At rt184, the resistant variants were detectable in 58.7% of the sequence, with the replacement of leucine by the wild‐type threonine in the first subject. Gradually, entecavir‐resistant variants increased in 82.3% of the leucine in the last subject. In conclusion, we demonstrated the amino acid substitutions of the serial nucleoside/nucleotide analog resistants. We revealed that drug‐resistant mutants appear unchanged at first glance, but actually there are low‐abundant mutations that may develop drug resistance against nucleoside/nucleotide analogs through the selection of dominant mutations. 相似文献
93.
94.
95.
96.
Shuichi Nagashima Tetsuji Wakabayashi Naoko Saito Manabu Takahashi Kenta Okada Ken Ebihara Shun Ishibashi 《Journal of diabetes investigation.》2020,11(5):1363-1365
Type A insulin resistance (IR) syndrome is a severe IR form caused by insulin receptor (INSR) gene defects. Antidiabetic drugs, including high‐dose insulin and insulin‐sensitizing agents, often fail to control associated hyperglycemia. Therapy with recombinant human insulin‐like growth factor 1 can be more effective, but it is expensive. We report a case of type A IR syndrome with an in‐frame INSR heterozygous deletion (ΔLeu999) that was treated with a combination of conventional therapy and ipragliflozin, a sodium–glucose cotransporter 2 inhibitor. Treatment reduced hemoglobin A1c levels (10.0–7.5%) and induced weight loss (54.4–52.0 kg) within 2 months, and the effects were sustained for >3 years. Sodium–glucose cotransporter 2 inhibitors might be useful to normalize blood glucose in type A IR syndrome by reducing bodyweight and ameliorating glucotoxicity. 相似文献
97.
Ito Y Kenmochi T Irino T Egawa T Hayashi S Nagashima A Kitagawa Y 《Hepato-gastroenterology》2012,59(118):1744-1747
Background/Aims: The prognosis remains unsatisfactory even if the patient undergoes extensive surgery, which is the only curative treatment for these tumors. Therefore, early detection and diagnosis are needed to improve long-term survival. To investigate the clinicopathological feature of extrahepatic cholangiocarcinoma in patients presenting without jaundice compared with the features of tumors in patients presenting with jaundice. Methodology: This was a retrospective study of 50 patients resected for extrahepatic cholangiocarcinoma. There were 15 non-jaundiced (Group A) and 35 jaundiced patients (Group B). Data on demographic and clinical features, surgical procedures and pathological diagnoses were collected retrospectively. Results: Preoperative mean serum levels of total bilirubin, aspartate aminotransferase, alanine aminotransaminase, alkaline phosphatase and gamma-glutamyltranspeptidase were statistically different between the groups. There was also a significant difference in the location of tumors. The distal tumors occurred in 9 non-jaundiced and 31 jaundiced patients (p=0.048). There were no significant differences between the characteristics and preoperative laboratory data of the patients with perihilar tumors and those with distal tumors. Conclusions: We believe that finding the disease in asymptomatic and non-jaundiced patients is very important for their prognosis. Further studies are needed and efforts should also continue to identify patients with suspicious findings. 相似文献
98.
99.
100.
Chie Shimizu Takayuki Fujita Yoshinobu Fuke Minako Yabuki Mamiko Kajiwara Seiichiro Hemmi Atsushi Satomura Masayoshi Soma 《International urology and nephrology》2013,45(3):803-808