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排序方式: 共有1721条查询结果,搜索用时 15 毫秒
991.
ShaSha Duan MM ShuJuan Li MM ZhenTing Sun MM YiLu Shi MM WenYan Fu MM Lei Zhang MM Jie Zhao MM YaXi Wang MM XiaoShan Zhang 《Echocardiography (Mount Kisco, N.Y.)》2020,37(5):788-790
Right atrial appendage aneurysms (RAAAs) are rare heart malformations, presenting as isolated anomalies or co-existing with other structural heart diseases. We describe a rare case of RAAA complicated with an atrial septal defect (ASD). The diagnosis was established using transthoracic echocardiography and confirmed using cardiac magnetic resonance imaging. To treat the ASD and reduced right atrium volume load, ASD transcatheter closure was performed. On echocardiography performed 3 months post discharge, the RAAA was observed to have reduced in size compared to that presurgery. Six years later, she was in good condition without any adverse events. 相似文献
992.
Background
This study compares the safety and efficacy of first-line treatments for anaplastic lymphoma kinase (ALK)-mutated non–small cell lung cancer (NSCLC).Methods
A comprehensive literature search was conducted in PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov databases. Abstracts related to lung cancer presented at important international conferences were also reviewed. Randomized clinical trials that qualified the inclusion criteria were subjected to Bayesian network meta-analysis and systematically reviewed.Results
The authors included a total of nine studies including 2441 patients and seven first-line treatments (ensartinib, brigatinib, crizotinib, lorlatinib, alectinib, ceritinib, and pemetrexed-based chemotherapy). Overall, lorlatinib appeared to confer the best progression-free survival (PFS) (probability of being the best [Prbest], 90%; surface under the cumulative ranking curve [SUCRA], 98%), and the same conclusion was obtained on paired comparisons (lorlatinib vs. ceritinib [hazard ratio (HR), 0.31; 95% confidence interval (CI), 0.20–0.47); lorlatinib vs. chemotherapy [HR, 0.17; 95% CI, 0.12–0.23]; crizotinib vs. lorlatinib [HR, 3.6; 95% CI, 2.4–5.2]; and brigatinib vs. lorlatinib [HR, 1.7; 95% CI, 1.0–2.8]). Alectinib conferred the best overall survival (OS) and safety profile. In the Asian population, ensartinib conferred the best PFS (Prbest 50%, SUCRA 87%), and for patients with brain metastases at baseline, lorlatinib showed the best PFS (Prbest 70%, SUCRA 93%).Conclusions
For first-line treatment of patients with ALK-positive NSCLC, lorlatinib was associated with the best PFS and objective response rate, but poorer safety profile, whereas alectinib demonstrated the best OS and safety profile. In Asians, ensartinib conferred the best PFS benefit, and in the brain baseline metastasis population, lorlatinib conferred the best PFS benefit.Plain Language Summary
- Among the many molecularly targeted drugs currently used to treat anaplastic lymphoma kinase mutation-positive non–small cell lung cancer, lorlatinib may be one of the most effective targeted drugs.
- Lung cancer has long been at the top of cancer rankings in terms of incidence and mortality.
- Today, the treatment of lung cancer has moved into the era of precision therapy.
- In this article, we use a statistical approach to compare the efficacy and safety of targeted drugs that have been used in the first-line treatment of anaplastic lymphoma kinase mutations to improve the reference for clinicians to make treatment decisions in the real world.
993.
994.
Esther MM Van Lieshout Gerdine H Van Kralingen Youssef El-Massoudi Harrie Weinans Peter Patka 《BMC musculoskeletal disorders》2011,12(1):34
Background
Many (artificial) bone substitute materials are currently available for use in orthopaedic trauma surgery. Objective data on their biological and biomechanical characteristics, which determine their clinical application, is mostly lacking. The aim of this study was to investigate structural and in vitro mechanical properties of nine bone substitute cements registered for use in orthopaedic trauma surgery in the Netherlands. 相似文献995.
996.
Sparsh Shah Joshua Murray Muhammad Mamdani Samuel Vaillancourt 《The American journal of emergency medicine》2019,37(8):1544-1546
ObjectivesWe sought to determine whether addition of a snowfall variable improves emergency department (ED) patient volume forecasting. Our secondary objective was to characterize the magnitude of effect of snowfall on ED volume.MethodsWe used daily historical patient volume data and local snowfall records from April 1st, 2011 to March 31st, 2018 (2542 days) to fit a series of four generalized linear models: a baseline model which included calendar variables and three different snowfall models with an indicator variable for either any snowfall (>0 cm), moderate snowfall (≥1 cm), or large snowfall (≥5 cm). To evaluate model fit, we examined the Akaike Information Criterion (AIC) and Bayesian Information Criterion (BIC). Incident rate ratios were calculated to determine the effect of snowfall in each model.ResultsAll three snowfall models demonstrated improved model fit compared to the model without snowfall. The best fitting model included a binary variable for snowfall (<1 cm vs. ≥1 cm). This model showed a statistically significant decrease in daily ED volume of 2.65% (95% CI: 1.23%–4.00%) on snowfall days.DiscussionThe addition of a snowfall variable results in improved model performance in short-term ED volume forecasting. Snowfall is associated with a modest, but statistically significant reduction in ED volume. 相似文献
997.
998.
Hans C. Lee Sikander Ailawadhi Cristina J. Gasparetto Sundar Jagannath Robert M. Rifkin Brian G. M. Durie Mohit Narang Howard R. Terebelo Kathleen Toomey James W. Hardin Lynne Wagner James L. Omel Mazaher Dhalla Liang Liu Prashant Joshi Rafat Abonour Connect® MM Registry 《Blood cancer journal》2021,11(7)
999.
1000.
Cameron J. Gilbert Tara Gomes Muhammad M. Mamdani Chelsea Hellings Zhan Yao Amit X. Garg Ron Wald Ziv Harel David N. Juurlink 《The Canadian journal of cardiology》2013