全文获取类型
收费全文 | 16966篇 |
免费 | 716篇 |
国内免费 | 137篇 |
专业分类
耳鼻咽喉 | 169篇 |
儿科学 | 360篇 |
妇产科学 | 123篇 |
基础医学 | 2141篇 |
口腔科学 | 303篇 |
临床医学 | 1089篇 |
内科学 | 4540篇 |
皮肤病学 | 444篇 |
神经病学 | 1371篇 |
特种医学 | 539篇 |
外科学 | 2700篇 |
综合类 | 46篇 |
一般理论 | 4篇 |
预防医学 | 371篇 |
眼科学 | 618篇 |
药学 | 1113篇 |
中国医学 | 28篇 |
肿瘤学 | 1860篇 |
出版年
2024年 | 13篇 |
2023年 | 106篇 |
2022年 | 262篇 |
2021年 | 445篇 |
2020年 | 215篇 |
2019年 | 271篇 |
2018年 | 346篇 |
2017年 | 272篇 |
2016年 | 368篇 |
2015年 | 413篇 |
2014年 | 500篇 |
2013年 | 609篇 |
2012年 | 1088篇 |
2011年 | 1147篇 |
2010年 | 682篇 |
2009年 | 577篇 |
2008年 | 1001篇 |
2007年 | 1142篇 |
2006年 | 1066篇 |
2005年 | 1212篇 |
2004年 | 1195篇 |
2003年 | 1054篇 |
2002年 | 1097篇 |
2001年 | 192篇 |
2000年 | 143篇 |
1999年 | 231篇 |
1998年 | 287篇 |
1997年 | 208篇 |
1996年 | 217篇 |
1995年 | 188篇 |
1994年 | 160篇 |
1993年 | 172篇 |
1992年 | 98篇 |
1991年 | 85篇 |
1990年 | 91篇 |
1989年 | 83篇 |
1988年 | 59篇 |
1987年 | 42篇 |
1986年 | 44篇 |
1985年 | 44篇 |
1984年 | 43篇 |
1983年 | 35篇 |
1982年 | 42篇 |
1981年 | 40篇 |
1980年 | 32篇 |
1979年 | 30篇 |
1978年 | 35篇 |
1977年 | 25篇 |
1976年 | 12篇 |
1975年 | 11篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Makoto Watanabe Takashi Fujimoto Masayuki Iwano Hideo Shiiki Shinobu Nakamura 《Nihon Rinshō Men'eki Gakkai kaishi》2002,25(2):191-198
We describe the case of a 61-year-old woman diagnosed with primary Sj?gren's syndrome (SS) after an 8-year history of IgA nephropathy and a 3-year history of recurrent purpuric rashes. Her two daughters had previously been diagnosed with other autoimmune diseases. One daughter had Graves' disease and the other had Hashimoto's disease and systemic lupus erythematosus. The diagnosis of SS was made based on dryness of mucous membranes, Shirmer test, and parotid sialography. Thrombocytopenia, high platelet-aggregated IgG (PA-IgG) level, and normal megakaryocytes count in bone marrow suggested that her recurrent purpuric rashes were due to idiopathic thrombocytopenic purpura (ITP). Patients with SS may develop other autoimmune diseases. This case aids understanding of the immune pathogenesis and genetic background of SS. 相似文献
32.
Estrogenic Induction of NADPH- Diaphorase Activity in the Preoptic Neurons Containing Estrogen Receptor Immunoreactivity in the Female Rat 总被引:1,自引:0,他引:1
Nitric oxide and estrogen have been shown to play a critical role in the control of female reproductive function. In order to determine an anatomical relationship between nitric oxide generating neurons and estrogen target neurons, NADPH-diaphorase histochemistry was combined with estrogen receptor immunohistochemistry in the female medial preoptic area. While only a few weakly stained neurons for NADPH-diaphorase were found in ovariectomized control rats, a drastic increase in NADPH-diaphorase activity was observed in the medial preoptic nucleus of estradiol-treated ovariectomized animals. The total number of NADPH-diaphorase neurons in the estradiol-treated group increased three-fold relative to controls, and more than 80% of those neurons contained estrogen receptor-immunoreactivity in their nuclei. Since neuronal NADPH-diaphorase is nitric oxide synthase, the present result suggests that nitric oxide synthase activity can be positively regulated by estradiol in neurons containing estrogen receptor in the female medial preoptic nucleus. 相似文献
33.
Koichi Shimizu M.D. Hirokuni Arai M.D. Tohru Sakamoto M.D. Makoto Sunamori M.D. Akio Suzuki M.D. 《Journal of cardiac surgery》1997,12(3):198-200
A bstract A 61-year-old woman suffering from Jarcho-Levin syndrome (JLS) was associated with atrial septal defect and partial anomalous pulmonary venous return and underwent corrective surgery. Pressure controlled postoperative ventilator therapy is preferred in patients with JLS. 相似文献
34.
Active oxygen species generated by monocytes and polymorphonuclear cells in Crohn's disease 总被引:4,自引:0,他引:4
Tetsuji Kitahora MD Koichi Suzuki MD Hitoshi Asakura MD Takeshi Yoshida MD Makoto Suematsu MD Mamoru Watanabe MD Sadakazu Aiso MD Dr. Masaharu Tsuchiya MD 《Digestive diseases and sciences》1988,33(8):951-955
Chemiluminescence (CL) analysis of monocytes and polymorphonuclear cells (PMNs) was performed on 13 patients with Crohn's disease (CD) and 10 healthy volunteers. The percentages of monocyte populations in mononuclear cells obtained from the patients with CD were greater than those from the healthy volunteers, but the numbers of PMNs were not different between the two groups. The peak level of phorbol myristate acetate (PMA)-induced CL activity generated by diluted whole blood from the patients with CD was more significantly elevated than that from the healthy volunteers, whereas the peak levels of opsonized zymosan-induced CL activity did not differ between the two groups. In monocytes, the peak levels of both PMA- and opsonized zymosan-induced CL activity were significantly higher in the patients with CD than in the healthy volunteers. CL in PMNs, however, showed no significant difference between CD and controls. It is suggested that monocytes of CD have a large capacity to generate active oxygen species. The present study suggests that excessive active oxygen species released by monocytes and perhaps macrophages may play an important role in formation of the intestinal lesions in CD.This work was supported by the Grant of Tokuteishitsukan from the Japanese Ministry of Welfare and Health. 相似文献
35.
Yuka Sakazume Makoto Tanaka Itsuo Isobe Rika Tominaga Eiji Nanba Koichi Okamoto 《Clinical neurology》2004,44(8):541-544
We reported a patient with middle-aged onset sialidosis type I. A 52-year-old Japanese man was referred to our hospital because of dysarthria, involuntary movement of his extremities and gait disturbance since the age of 46 years. On admission, neurological examination revealed scanning speech, action myoclonus, cerebellar ataxia and cherry-red spots. Vacuolated lymphocytes were found in peripheral blood. Brain 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography (18F-FDG PET) showed decreased glucose metabolism in the cerebellum. Enzymological analysis using his skin fibroblasts revealed primary deficiency of sialidase activity. Sialidase gene analysis identified compound heterozygotes for base substitusions of 239T-to-C and 649G-to-A, which resulted in amino acid alterations of P80L and V217M, respectively. These mutations have been reported in Japanese sialidosis type II (P80L) and I (V217M). Further studies are required to reveal effects of gene mutations on residual enzyme activities and phenotypes. 相似文献
36.
37.
Newborn infant with maternal anti-SSA antibody-induced complete heart block accompanying cardiomyopathy. 总被引:2,自引:0,他引:2
Newborn case of maternal anti-SSA antibody-induced congenital complete heart block (CCHB) accompanying cardiomyopathy is presented. Unexpectedly, she died of ventricular tachycardia, not bradycardia, 6 days after birth. Autopsy revealed left ventricular cardiomyopathy with endocardial fibroelastosis. Thus, when evaluating fetal cardiac performance in cases of maternal anti-SSA antibody-induced CCHB, it is necessary to pay attention to myocardial attributes such as endocardial hyperplasia. 相似文献
38.
Health-related quality of life among persons living in Japan with a permanent colostomy. 总被引:2,自引:0,他引:2
Naomi Ito Makoto Tanaka Keiko Kazuma 《Journal of wound, ostomy, and continence nursing》2005,32(3):178-83; quiz 184-5
OBJECTIVE: To compare the health-related quality of life (HRQOL) of persons with a permanent colostomy to that of the general Japanese population and explore the factors influencing HRQOL. DESIGN: A cross-sectional survey. SETTING AND SUBJECTS: A total of 255 persons with an ostomy who attended a meeting of the Japan Ostomy Association in the Kanto region of Japan. INSTRUMENTS: The HRQOL was assessed using Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), Japanese version 1.2. Factors potentially influencing the HRQOL were age, sex, marital status, employment status, number of people in the household, time since colostomy, and diagnosis. METHODS: Questionnaires were distributed to the subjects and SF-36 scores were determined and compared with the corresponding national-norm data by Wilcoxon signed rank sum test. A logistic regression analysis was used to explore the influencing factors. RESULTS: The questionnaire response rate was 66.7%. Subjects with a urostomy or an ileostomy and those with missing data were excluded. Data from 102 subjects with a permanent colostomy were analyzed. The subjects' scores were significantly lower than the national-norm scores in the role-physical and social functioning scales. Being employed was associated with significantly lower scores or associated with a tendency toward lower scores. CONCLUSIONS: Scores in two scales in these subjects were lower than those of national-norm scores. Being employed had a negative impact on the HRQOL of subjects with a permanent colostomy. The results of this study provide reference data for future research and underscore the importance of support for persons with a colostomy. 相似文献
39.
Heat Flow and Distribution during Epidural Anesthesia 总被引:43,自引:0,他引:43
40.
Yohei Ogawa Makoto Hiura Toru Kikuchi Keisuke Nagasaki Yukie Iwata Makoto Uchiyama 《Clinical Pediatric Endocrinology》2004,13(1):55-58
This study aimed to investigate the levels of serum low-density lipoprotein
cholesterol (LDLC) using direct measurement in healthy Japanese school children. The
subjects were 621 children (325 boys and 296 girls) aged 9 to 10 in the 4th grade, and 688
children (334 boys and 354 girls) aged 12 to 13 in the 7th grade. The levels of serum LDLC
and high-density lipoprotein cholesterol were measured by direct determination (Cholestest
LDL and Cholestest NHDL; Daiichi Pure Chemicals Co., Ltd., Tokyo, Japan). In boys in the
4th grade, the mean, the 75th, the 90th and the 95th percentiles of LDLC levels (mg/dl)
were 91.6, 104, 124 and 134, respectively. In girls in the 4th grade, they were 92.8, 108,
122 and 130. In boys in the 7th grade, they were 83.4, 96, 113 and 123. In girls in the
7th grade, they were 93.0, 106, 126 and 137. Serum LDLC levels in boys in the 7th grade
were lower than those of other groups. The direct measurement of serum LDLC level is
useful for evaluation of dyslipidemia in healthy school children, because the method is
applicable to non-fasting serum. 相似文献