Neuroendocrine dysfunction in female patients with systemic dysplasia of the connective tissue

The study covered 119 women with systemic undifferentiated dysplasia of the connective tissue (DCT) aged 14-39 years. All the examinees had vegetative disorders, 26.1% had a neuroendocrine-metabolic form of hypothalamic syndrome (HS), 51.3%--premenopausal syndrome, 65.5%--dysmenorrhea. It was found that women with DCT and HS develop symptoms of neuroendocrine disorders at earlier age than those with HS but free of DCT. Arterial hypertension was registered in 96.8% of patients with DCT and HS, 80.3% of DCT patients with premenopausal syndrome. Central hemodynamics was different in DCT patients without neuroendocrine disorders and with neuroendocrine dysfunction evidencing the role of the latter in development of arterial hypertension in DCT.     

Antiinflammatory effect of russian-made budesonide in experimental noninfectious pulmonary granulomatosis

We studied the antiinflammatory effect of a Russian-made glucocorticoid budesonide administered by inhalation and intraperitoneal injection to rats with experimental noninfectious pulmonary granulomatosis. The antiinflammatory effects of budesonide at both administration routes were similar. Intraperitoneal injection, in contrast to inhalation, produced a systemic effect manifested in suppression of hyperplasia of non-encapsulated lymphoid formations in the mucosa.     

Time-dependent effects of antihypertensive agents and chronocorrecting action of melatonin in patients with arterial hypertension

The chronopharmacodynamics of angiotension-converting enzyme (ACE) inhibitors, such as ramipril (R), enalapril (E), acetene (A), caposide-50 (C-50) and the effect of the epiphyseal neurohormone melatonin used alone and in combination with cozaar (Co) and cintome (Ci) in the randomized groups including 124 patients with arterial hypertension (AH). The ACE inhibitors were given in the morning, afternoon, and evening. Co and Ci were used in the morning. Melatonin was given at 10.00 p.m. 10-14 days before and after therapy, 24-hour monitoring (Astracard, Russia) and echocardiography (Toshiba, Japan) were performed. Analyzing the findings indicated the time-dependent hemodynamic effects of R, E, and C-50. Ci, A, and Co were found to have antihypertensive and vasodilatory effects without normalizing the chronostructure of circadian rhythms of major hemodynamic parameters. By producing antihypertensive and vasodilatory effects, melatonin leads to the recovery of circadian hemodynamic organization when used alone and in combination with Co, Ci, and ACE inhibitors.     

Antiviral Activity of Compounds Based on (1-Adamantyl)bromomethyl Ketone

Pharmaceutical Chemistry Journal -     

Use of cultivation-dependent and -independent techniques to assess contamination of central venous catheters: a pilot study

Background  

Catheters are the most common cause of nosocomial infections and are associated with increased risk of mortality, length of hospital stay and cost. Prevention of infections and fast and correct diagnosis is highly important.     

Morphology and pathogenesis of chronic bronchitis

Histologic and ultrastructural features of the chronic catarrhal bronchitis are presented and its pathogenetic mechanisms are discussed. An important role in the development of bronchitis of the mucociliary transport system damage, retention of the mucus and bacterial contamination of the respiratory tract is analysed. Current hypothesis of the chronic bronchitis development based on the disturbance of the protease-antiprotease and oxidative-antioxidative balance is presented. The data on the role of the specific and non-specific local immune mechanisms of the lung defence in the development of the exacerbations are given.