全文获取类型
收费全文 | 831篇 |
免费 | 46篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 49篇 |
妇产科学 | 7篇 |
基础医学 | 119篇 |
口腔科学 | 12篇 |
临床医学 | 93篇 |
内科学 | 140篇 |
皮肤病学 | 16篇 |
神经病学 | 19篇 |
特种医学 | 120篇 |
外科学 | 84篇 |
综合类 | 106篇 |
预防医学 | 59篇 |
眼科学 | 3篇 |
药学 | 36篇 |
中国医学 | 1篇 |
肿瘤学 | 23篇 |
出版年
2021年 | 8篇 |
2020年 | 7篇 |
2017年 | 10篇 |
2016年 | 9篇 |
2015年 | 17篇 |
2014年 | 27篇 |
2013年 | 17篇 |
2012年 | 27篇 |
2011年 | 19篇 |
2010年 | 34篇 |
2009年 | 33篇 |
2008年 | 36篇 |
2007年 | 30篇 |
2006年 | 20篇 |
2005年 | 21篇 |
2004年 | 14篇 |
2003年 | 16篇 |
2002年 | 15篇 |
2001年 | 19篇 |
2000年 | 10篇 |
1999年 | 17篇 |
1998年 | 48篇 |
1997年 | 40篇 |
1996年 | 31篇 |
1995年 | 20篇 |
1994年 | 30篇 |
1993年 | 23篇 |
1992年 | 8篇 |
1991年 | 13篇 |
1990年 | 9篇 |
1989年 | 22篇 |
1988年 | 23篇 |
1987年 | 32篇 |
1986年 | 10篇 |
1985年 | 20篇 |
1984年 | 8篇 |
1983年 | 9篇 |
1982年 | 16篇 |
1981年 | 7篇 |
1978年 | 9篇 |
1976年 | 8篇 |
1975年 | 10篇 |
1974年 | 9篇 |
1973年 | 7篇 |
1972年 | 6篇 |
1970年 | 7篇 |
1969年 | 5篇 |
1968年 | 7篇 |
1966年 | 5篇 |
1965年 | 5篇 |
排序方式: 共有892条查询结果,搜索用时 15 毫秒
51.
Brown AS Calachanis M Evdoridis C Hancock J Wild S Prasan A Nihoyannopoulos P Monaghan MJ 《Irish journal of medical science》2004,173(1):13-17
Background Stress echocardiography is useful for assessing patients with coronary artery disease unable to undergo formal exercise testing.
Considerable skill is required to avoid large intra- and inter-observer variability due to poor endocardial definition. Intravenous
ultrasound contrast agents are now available which may improve this variability.
Aim To study intravenous Sonovue in assessing wall motion score and ejection fraction (EF) during stress echocardiography.
Methods Thirty-eight patients undergoing arbutamine stress echocardiography for known or suspected coronary artery disease were studied.
Echocardiographic analysis of wall motion score index, endocardial border detection (EBD) and EF was performed at rest and
at peak stress before and after intravenous injection of Sonovue, by experienced and inexperienced observers.
Results All three observers noted an improvement in endocardial border definition following Sonovue (p=<0.001). At baseline, there
was a significant difference in wall motion score index between experienced and inexperienced observers at rest (p=0.01) and
at peak stress (p=0.001). Following Sonovue administration this was no longer significant (p=0.07, p=0.114). Intra-observer
variability of end diastolic, end systolic volumes (ESV) and EF improved following contrast (p<0.05) at rest and during stress.
Conclusion Sonovue significantly improved EBD and reduced intra-observer variability of EF at rest and during peak arbutamine infusion. 相似文献
52.
The new drug cerebral, as well as its low-molecular-weight (LMW) fraction (MW, < or = 500 Da) separated from a ready-to-use commercial form of this new neutrotropic drug, increases the level of synthesis and secretion of the nerve growth factor (NGF) in rats under conditions of experimental hemorrhagic stroke (HS), while not influencing the NGF synthesis and secretion in intact animals. This neuroactivating effect of the trophinotropic drug cerebral and its LMW fraction in the acute HS development stage was observed upon intranasal administration. In comparison with parenteral (intraperitoneal) administration, the intranasal introduction provides for the optimum drug delivery to the CNS bypassing the blood-brain barrier. Trophinotropic agents are a new class of drugs with neuroactivating mechanism of action upon the NGF synthesis and secretion under HS conditions. 相似文献
53.
There have been significant changes in the doctor patient relationship with the impact of technology in day-to-day practice. More and more patients are aware of their rights and are keen to make free choice and decision on their treatment. This helps them to choose the treatment of their choice from the options available and to select a physician of their choice. Doctor's decisions are being questioned regarding their correctness and there is a need to educate the patient, on what one offers by way of treatment. In some procedures and types of treatment, patient needs to be educated and informed of the merits and demerits of the treatment available. This will help the patient to make appropriate choice and also to accept some adverse outcome of treatment. Towards this end, all countries are looking afresh at the necessity of Informed Consent. Methods adopted by some countries are highlighted to help our physicians practice them in an appropriate way. A lot of remedial work needs to be done to minimize future litigation, as many doctors misunderstand their legal obligations and haven't caught up with the change in judge's thinking. 相似文献
54.
Oberyszyn TM; Conti CJ; Ross MS; Oberyszyn AS; Tober KL; Rackoff AI; Robertson FM 《Carcinogenesis》1998,19(3):445-455
The beta2 integrin (CD 18/CD 11 a, b, c) family of proteins mediate
adherence of leukocytes to vascular endothelium and the associated ligand,
intercellular adhesion molecule-1 (ICAM-1; CD 54), interacts with beta2
integrin proteins to allow transendothelial migration of leukocytes into
sites of inflammation. The present study examines the function of these
proteins in a murine model of acute cutaneous inflammation induced
following topical application of 12-O- tetradecanoylphorbol-13-acetate
(TPA) to the dorsal epidermis of SENCAR mice and in a model of skin
multistage carcinogenesis. At 24 h following topical application of TPA to
the dorsal epidermis of mice, dermal leukocytes expressed higher levels of
beta2 integrin protein compared with the lower levels of beta2 integrin
protein expression by peripheral blood leukocytes. ICAM-1 protein was
localized to epidermal keratinocytes and vascular endothelium in
TPA-treated skin and to proliferating papilloma cells. Intravenous (i.v.)
injection of either 50 microg anti-beta2 integrin antibody alone or in
combination with anti-ICAM-1 antibody significantly inhibited both
TPA-stimulated neutrophil infiltration into the dermis (P < 0.001) and
myeloperoxidase (MPO) activity (P < 0.03 anti-beta2 integrin antibody; P
< 0.01 anti- beta2 integrin + ICAM-1 adhesion molecule antibodies), but
had no effect on TPA-induced epidermal hyperplasia. In addition, injection
of either anti-ICAM-1 adhesion molecule antibody alone (P < 0.004) or in
combination with anti-beta2 integrin antibody (P < 0.001) significantly
inhibited TPA-induced production of 7,8-dihydroxy-2'-deoxyguanosine (8-
OHdG) immunoreactive proteins by epidermal keratinocytes. Beta2
integrin/ICAM-1 adhesion molecules work in concert to regulate migration,
retention and functional activation of leukocytes within the dermis during
TPA-induced skin inflammation and within stromal tissue of papillomas that
form during multi-stage carcinogenesis. Agents that inhibit these
receptor/ligand interactions may be useful in defining the roles of
specific cell populations in cutaneous inflammation and multistage
carcinogenesis and may also have potential as anti-promoting and
anti-progression agents.
相似文献
55.
56.
敏定偶用于35岁以上妇女的疗效、安全性和周期控制 总被引:11,自引:0,他引:11
<正> 口服避孕药在投放市场之初,应用于各种年龄段的妇女。然而资料显示早期使用的高剂量口服避孕药会增加心肌梗塞的发病率;在1975年,美国食品药物管理局(FDA)不建议40岁以上的妇女服用避孕药,对30岁以上的吸烟妇女建议她们要么停止吸烟要么改换避孕方式。随着研究的进一步深入及低剂量口服避孕药的问市,已证实任何年龄的非吸烟 相似文献
57.
58.
We report 8 infants with immediate hypersensitivity reactions to foods (milk, egg, or peanut), occurring at the first-known exposure. Each developed symptoms within the first hour, but these generally settled within 2 hours. Sensitisation to the food concerned was demonstrated by positive immediate allergen skin prick tests in every case. Symptoms experienced included irritability, erythematous rash, urticaria, angio-oedema, vomiting, rhinorrhoea, and cough. Five infants were being followed prospectively and 4 were clinically tolerant of the food by age 16 months. The most likely route of sensitisation was via breast milk. None of the infants experienced similar reactions while being breast fed, suggesting that the reaction was dose dependent. As 5 out of a group of 80 infants being followed prospectively developed an immediate reaction at their first known exposure to a food, this appeared to be a not uncommon presentation of food hypersensitivity in infancy. 相似文献
59.
N A Makarenko M E Pavlenko V I Vysovich A I Demchenko A A Pan'kova 《Gigiena truda i professional'nye zabolevaniia》1989,(6):1-4
The study was designed to explore occupational morbidity levels, dynamics and structure in workers of the Krivbas ore works during 1961-1985. Workers' profession, age and length of service were taken into account. It was shown that further decrease of occupational morbidity could be achieved due to carrying out of the proposed recommendations. 相似文献
60.
AS Winkler B Stelzhammer K Kerschbaumsteiner M Meindl W Dent J Kaaya W Matuja & E Schmutzhard 《Cephalalgia : an international journal of headache》2009,29(12):1317-1325
The aim of the study was to assess the prevalence of headache with special attention to tension-type headache (TTH) in a rural area in northern Tanzania. A door-to-door study was performed using a standardized and validated questionnaire. A total of 7412 participants were screened. The total headache prevalence during the past year was 12.1%; the overall 1-year prevalence of TTH was 7%; 5% reported episodic TTH and 0.4% chronic TTH. Borderline cases (International Headache Society code 2.3) were described in 1.6%. The prevalence of headache was highest in the 41–50-year-old group in women and in the 61+ age group in men. This is the first account of the prevalence of TTH in a rural Tanzanian population, and shows that headache in general and, more specifically, TTH are prevalent disorders that deserve attention. However, the prevalence of primary headache seems to be lower than in Western countries. 相似文献