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排序方式: 共有2717条查询结果,搜索用时 15 毫秒
61.
Satoshi Inoue Zhenyue Hao Andrew J. Elia David Cescon Lily Zhou Jennifer Silvester Bryan Snow Isaac S. Harris Masato Sasaki Wanda Y. Li Momoe Itsumi Kazuo Yamamoto Takeshi Ueda Carmen Dominguez-Brauer Chiara Gorrini Iok In Christine Chio Jillian Haight Annick You-Ten Susan McCracken Andrew Wakeham Danny Ghazarian Linda J.Z. Penn Gerry Melino Tak W. Mak 《Genes & development》2013,27(10):1101-1114
62.
Yu Ben C. L. Mak Winnie W. S. Chio Floria H. N. 《Social psychiatry and psychiatric epidemiology》2021,56(3):401-408
Social Psychiatry and Psychiatric Epidemiology - Family has been found to have an influential role on clinical and recovery outcomes of people with schizophrenia. While recovery-oriented services... 相似文献
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64.
Dimeric bis (heptyl)‐Cognitin Blocks Alzheimer's β‐Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils 下载免费PDF全文
65.
Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent 下载免费PDF全文
Susan E. Andrew Margaret McKinnon Benjamin S. Cheng Agnes Francis Janice Penney Armin H. Reitmair Tak W. Mak Frank R. Jirik 《Proceedings of the National Academy of Sciences of the United States of America》1998,95(3):1126-1130
The mutational response of mismatch repair-deficient animals to the alkylating agent N-methyl-N-nitrosourea was evaluated by using a transgenic lacI reporter system. Although the mutations detected in MSH2 heterozygotes were similar to those of controls, MSH2−/− animals demonstrated striking increases in mutation frequency in response to this agent. G:C to A:T transitions at GpG sites, as opposed to CpG sites, dominated the mutational spectrum of both MSH2+/+ and MSH2−/− N-methyl-N-nitrosourea -treated animals. Extrapolating to humans with hereditary non-polyposis colorectal cancer, the results suggest that MSH2 heterozygotes are unlikely to be at increased risk of mutation, even when exposed to potent DNA methylating agents. In contrast, mismatch repair-deficient cells spontaneously arising within individuals with hereditary non-polyposis colorectal cancer would likely exhibit hypermutability in response to such mutagens, an outcome predicted to accelerate the pace of tumorigenesis. 相似文献
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作为标准化的非手术治疗,诱导化疗(ICT)在治疗局部晚期头颈鳞癌已有几十年的历史,但是关于其作用尚存争议。同期放化疗(CRT)是目前标准化的非手术治疗,然而由于ICT能够使肿瘤体积缩小,提高放疗的可行性,改善患者对放疗的耐受力,增加放疗后器官功能保留的可能性及降低远处转移率。所以,对ICT的研究从未停止。该文对近期随机试验进行回顾分析,与手术或单独CRT比较,评估ICT中紫杉醇的价值。Meta分析比较ICT中紫杉醇和顺铂及5氟尿嘧啶的作用。之前的随机试验中,并没有ICT提高生存率的报道。但 相似文献
68.
Andrew M. Zeiger Meghan E. McGarry Angel C. Y. Mak Vivian Medina Sandra Salazar Celeste Eng Amy K. Liu Sam S. Oh Thomas J. Nuckton Deepti Jain Thomas W. Blackwell Hyun Min Kang Goncalo Abecasis Leandra Cordero Oate Max A. Seibold Esteban G. Burchard Jose Rodriguez‐Santana 《Pediatric pulmonology》2020,55(2):533-540
69.
Kwan‐Lung Ko Wai‐Pan To Lung‐Yi Mak Wai‐Kay Seto Qin Ning James Fung Ching‐Lung Lai Man‐Fung Yuen 《Journal of viral hepatitis》2020,27(4):397-406
Real‐world studies examining reduction in risk of hepatocellular carcinoma (HCC) in patients receiving antivirals are limited by the small size of the studies, or by data insufficiency and heterogeneity with short follow‐up duration. We aimed to examine the real‐world long‐term outcome of patients receiving entecavir treatment on HCC incidence and HBsAg seroclearance. The incidence of HCC in 1225 entecavir‐treated patients between 2002 and 2015 was compared with the HCC incidence estimated using the REACH‐B, GAG‐HCC and CU‐HCC scores. Standardized incidence ratios (SIR) were calculated. The impact of entecavir treatment on HBsAg seroclearance was also explored. The median follow‐up of the cohort was 6.6 years, with 66 cases of HCC development. Using the REACH‐B model, the reduction of HCC risk was significant from year 6 onwards with SIR of 0.68 (95% CI 0.535‐0.866) at year 10. In subgroup patients without cirrhosis, consistent risk reduction was observed from the fifth year and the SIR reached 0.51 (95% CI 0.271‐0.704) by year 10. Benefit in cirrhotic patients was demonstrated when using the GAG‐HCC and CU‐HCC score, with the SIR at year 10 being 0.38 (95% CI 0.259‐0.544) and 0.46 (95% CI 0.314‐0.659), respectively. The cumulative rate of HBsAg seroclearance was 5.2%. HBsAg level at third year of treatment and baseline‐to‐3‐year percentage reduction was predictive of subsequent HBsAg seroclearance. In conclusion, long‐term entecavir therapy was associated with significant reduction in the risk of HCC in the real world. However, HBsAg seroclearance rate remained low. Additional therapy may be considered in patients with adverse predictive factors for subsequent HBsAg seroclearance. 相似文献
70.
Jennifer Sze Man Mak Terence T. Lao Maran Bo Wah Leung Cathy Hoi Sze Chung Jacqueline Pui Wah Chung Lai Ping Cheung Tin‐Chiu Li 《Journal of viral hepatitis》2020,27(2):110-117
Hepatitis B virus (HBV) can be found in ovarian tissues. This study compared HBV DNA levels in follicular fluid collected during oocyte retrieval with paired serum samples in HBV carriers after ovarian stimulation during IVF treatment for infertility. Sixty‐four HBV carrier women referred to the Assisted Reproductive Units of two Hong Kong hospitals were recruited. At oocyte retrieval, the follicular fluid aspirated from the first follicle was collected for study. In 22 women, the first follicular fluid sample from both ovaries was similarly collected and studied. These women were also tested for liver function test and HBeAg. In 28 (43.8%) women, HBV DNA was detected in follicular fluid and the level correlated with serum levels (Spearman's correlation P < .001). There was concordant detection of HBV DNA in both ovaries, and the levels were significantly correlated (Spearman's correlation P = .029). In 40% of women with FF HBV DNA, the follicular fluid:serum ratio was >1.0, suggesting stimulation of HBV replication. These women also had significantly different liver function test results. Increased HBV replication exists in 40% of women with HBV DNA detected in follicular undergoing ovarian stimulation during IVF treatment. 相似文献