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951.
Mehdi BAMOROVAT Iraj SHARIFI Mohammad Ali MOHAMMADI Majid FASIHI HARANDI Mehdi MOHEBALI Reza MALEKPOUR AFSHAR Zahra BABAEI Nasser ZIAALI Mohammad Reza AFLATOONIAN 《Iranian Journal of Parasitology》2014,9(3):342-349
Background
Canine visceral leishmaniasis (CVL) is a systemic disease with a high mortality rate, caused by a diphasic protozoan parasite, Leishmania infantum/chagasi in the world. The objective of the present study was to determine the presence of CVL in the city and suburbs of Kerman, using a range of serological, histopathological and molecular methods.Methods
Blood samples were taken from 80 clinically symptomatic stray dogs All the collected blood samples were tested by direct agglutination test (DAT) to detect the anti-Leishmania antibodies in dogs, using a cut-off value of ≥1:320. Pathological specimens including spleen, liver and lymph nodes were prepared for paraffin blocks, sectioning, staining and final microscopic examination in the pathology laboratory. PCR amplification of kDNA from 9 samples of DAT positive stray dogs was studied.Results
The anti-Leishmania antibody was detected in 9 dogs (11.25 %) of the total 80 studied dogs. No significant difference was found between VL infection and gender. In contrast, there was a significant difference between seropositivity and age (P<0.05). Pathological samples showed changes including hyperplasia of infected macrophages and inflammatory cells that occupied sinusoids and splenic cords. Among the samples which was characterized by PCR, only one specimen revealed to be mixed infection between L. infantum and L. tropica.Conclusion
The results revealed a high prevalence of L. infantum infection in stray dogs in Kerman. This kind of information is needed for implementation of future control programs. 相似文献952.
Maryam Saberi-Karimian Amin Mansoori Maryam Mohammadi Bajgiran Zeinab Sadat Hosseini Amir Kiyoumarsioskouei Elias Sadooghi Rad Mostafa Mahmoudi Zo Negar Yeganeh Khorasani Mohadeseh Poudineh Sara Ghazizadeh Gordon Ferns Habibollah Esmaily Majid Ghayour-Mobarhan 《Journal of clinical laboratory analysis》2023,37(1):e24798
953.
954.
Majid Mokhtari Hamid Attarian Masoud Norouzi Mehran Kouchek Babak Sharif Kashani Fereidoun Sirati Behin Pourmirza Elham Mir 《Thrombosis research》2014
Background
Venous thromboembolism (VTE) is a major health issue worldwide. Data about VTE prophylaxis practices in developing countries are scarce.Objectives
The primary objectives of this survey were to define the VTE risk factors in hospitalized patients, to determine the rates of VTE prophylaxis administration and guideline compliance and to assess the effects of an educational program on VTE prophylaxis practices in Iran.Patients and Methods
Data on 1219 patients from twenty hospitals in Iran were extracted from the AVAIL-ME Extension project main databank. VTE risks were categorized according to the Caprini Risk Assessment Model. Logistic regression analysis was carried out to assess factors influencing VTE prophylaxis. We also examined the impact of an educational program which consisted of awareness, risk assessment, internal protocol implementation and re-assessment, on VTE prophylaxis practices.Results
Of 1219 patients, 789 (65%) and 430 (35%) were surgical and medical, respectively. VTE risks, categorized in low, moderate, high and very high were detected in 14%, 17%, 26% and 43% of patients respectively with a total of 1042(85%) patients being at risk for VTE. Of 882 (85%) eligible patients for VTE prophylaxis, 737 (83.5%) received any drug prophylaxis of whom 265 (62%) were medical and 472 (60%) were surgical. ACCP guidelines compliance was 60% and 33% in surgical and medical patients respectively. Any VTE prevention, drug prophylaxis, mechanical prophylaxis and guideline adherence were, 48% vs. 64%, 45% vs. 60%, 6% vs. 9% and 34% vs. 45% respectively (p < 00.1) before and after implementation of the VTE educational program.Conclusions
Despite an overall improvement in VTE prevention, areas such as inappropriate use of VTE prophylaxis in a large number of patients, significant under-use of mechanical devices and guideline adherence require closer attention. VTE awareness education is beneficial in improving VTE prophylaxis in Iran. 相似文献955.
Childhood obesity has reached epidemic proportions worldwide. With adult obesity-related co-morbidities now appearing in obese children, there has been a big push to educate the population and establish effective weight-losing initiatives. However, the limited success of non-operative methods has led to the introduction of bariatric surgery in the under 18-year olds. Laparoscopic Roux-en-Y gastric bypass is the most commonly performed operation, followed by the adjustable gastric band and sleeve gastrectomy. This review seeks to present the current position of bariatric surgery in the treatment of obese adolescents, and reviews the available evidence on selection and outcome, as well as the inherent uncertainties, particularly within the UK. 相似文献
956.
Makenzie Saoura Christopher A. Powell Robert Kopajtich Ahmad Alahmad Haya H. AL‐Balool Buthaina Albash Majid Alfadhel Charlotte L. Alston Enrico Bertini Penelope E. Bonnen Drago Bratkovic Rosalba Carrozzo Maria A. Donati Michela Di Nottia Daniele Ghezzi Amy Goldstein Eric Haan Rita Horvath Joanne Hughes Federica Invernizzi Eleonora Lamantea Benjamin Lucas Kyla‐Gaye Pinnock Maria Pujantell Shamima Rahman Pedro Rebelo‐Guiomar Saikat Santra Daniela Verrigni Robert McFarland Holger Prokisch Robert W. Taylor Louis Levinger Michal Minczuk 《Human mutation》2019,40(10):1731-1748
Mutations in either the mitochondrial or nuclear genomes are associated with a diverse group of human disorders characterized by impaired mitochondrial respiration. Within this group, an increasing number of mutations have been identified in nuclear genes involved in mitochondrial RNA metabolism, including ELAC2. The ELAC2 gene codes for the mitochondrial RNase Z, responsible for endonucleolytic cleavage of the 3′ ends of mitochondrial pre‐tRNAs. Here, we report the identification of 16 novel ELAC2 variants in individuals presenting with mitochondrial respiratory chain deficiency, hypertrophic cardiomyopathy (HCM), and lactic acidosis. We provide evidence for the pathogenicity of the novel missense variants by studying the RNase Z activity in an in vitro system. We also modeled the residues affected by a missense mutation in solved RNase Z structures, providing insight into enzyme structure and function. Finally, we show that primary fibroblasts from the affected individuals have elevated levels of unprocessed mitochondrial RNA precursors. Our study thus broadly confirms the correlation of ELAC2 variants with severe infantile‐onset forms of HCM and mitochondrial respiratory chain dysfunction. One rare missense variant associated with the occurrence of prostate cancer (p.Arg781His) impairs the mitochondrial RNase Z activity of ELAC2, suggesting a functional link between tumorigenesis and mitochondrial RNA metabolism 相似文献
957.
958.
Salehi Zahra Sharifynia Somayeh Jamzivar Fatemehsadat Shams-Ghahfarokhi Masoomeh Poorabdollah Mihan Abtahian Zahra Nasiri Naser Marjani Majid Moniri Afshin Salehi Mohammadreza Tabarsi Payam Razzaghi-Abyaneh Mehdi 《European journal of clinical microbiology & infectious diseases》2023,42(7):853-864
European Journal of Clinical Microbiology & Infectious Diseases - Pulmonary aspergillosis is a life-threatening fungal infection with worldwide distribution. In the present study, clinical... 相似文献
959.
This study determined the relationship between anthropometric status of 3-5-year-old urban children and theirs mothers' educational levels and employment status in Rasht City, northern Iran. A total of 1319 children (638 girls and 681 boys) at the ages of 3 and 6 years in all day-care centres in Rasht City were studied, using a cross-sectional design. Height and weight of the children were measured, and data on mothers' educational levels, employment status and duration of any breastfeeding were collected. Height for age, weight for age and weight for height of the children were compared with the National Center for Health Statistics (NCHS) reference population of the United States, and z-values 12 years of schooling, OR = 1.87; 95% CI: 1.08-2.4) had higher relative risk for underweight than children of mothers with an intermediate level of education (5-12 years of schooling). Children of mothers with college education were also more at risk for development of stunting (OR = 1.41; 95% CI: 1.14-4.22). In addition, children of employed mothers were more likely to be underweight (OR = 1.52; 95% CI: 1.05-2.31), stunted (OR = 2.42; 95% CI: 1.21-6.35) and wasted (OR = 3.35; 95% CI: 1.21-5.58) than children of non-employed mothers. The relative risk for undernutrition was higher in the children of both less and highly educated mothers compared with children of mothers with an intermediate level of education. Mothers' employment was also negatively related to nutritional status of these children in day-care centres in Rasht City. 相似文献
960.
Mohammad Eftekhari Majid Assadi Majid Kazemi Mohsen Saghari Armaghan Fard Esfahani Babak Fallahi Sichani Ali Gholamrezanezhad Davood Beiki 《BMC medical physics》2005,5(1):1-7