全文获取类型
收费全文 | 198篇 |
免费 | 24篇 |
专业分类
儿科学 | 7篇 |
基础医学 | 30篇 |
临床医学 | 34篇 |
内科学 | 32篇 |
皮肤病学 | 2篇 |
神经病学 | 45篇 |
特种医学 | 9篇 |
外科学 | 36篇 |
预防医学 | 10篇 |
眼科学 | 1篇 |
药学 | 6篇 |
肿瘤学 | 10篇 |
出版年
2023年 | 2篇 |
2022年 | 5篇 |
2021年 | 10篇 |
2020年 | 6篇 |
2019年 | 11篇 |
2018年 | 10篇 |
2017年 | 9篇 |
2016年 | 7篇 |
2015年 | 8篇 |
2014年 | 12篇 |
2013年 | 14篇 |
2012年 | 27篇 |
2011年 | 19篇 |
2010年 | 14篇 |
2009年 | 11篇 |
2008年 | 11篇 |
2007年 | 9篇 |
2006年 | 10篇 |
2005年 | 8篇 |
2004年 | 5篇 |
2003年 | 3篇 |
2002年 | 2篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 2篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1988年 | 1篇 |
1976年 | 1篇 |
排序方式: 共有222条查询结果,搜索用时 0 毫秒
51.
Liu QS Xu Q Arcuino G Kang J Nedergaard M 《Proceedings of the National Academy of Sciences of the United States of America》2004,101(9):3172-3177
Exogenous kainate receptor agonists have been shown to modulate inhibitory synaptic transmission in the hippocampus, but the pathways involved in physiological activation of the receptors remain largely unknown. Accumulating evidence indicates that astrocytes can release glutamate in a Ca(2+)-dependent manner and signal to neighboring neurons. We tested the hypothesis that astrocyte-derived glutamate activates kainate receptors on hippocampal interneurons. We report here that elevation of intracellular Ca(2+) in astrocytes, induced by uncaging Ca(2+), o-nitrophenyl-EGTA, increased action potential-driven spontaneous inhibitory postsynaptic currents in nearby interneurons in rat hippocampal slices. This effect was blocked by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate glutamate receptor antagonists, but not by selective AMPA receptor or N-methyl-d-aspartate receptor antagonists. This pharmacological profile indicates that kainate receptors were activated during Ca(2+) elevation in astrocytes. Kainate receptors containing the GluR5 subunit seemed to mediate the observed effect because a selective GluR5-containing kainate receptor antagonist blocked the changes in sIPSCs induced by Ca(2+) uncaging, and bath application of a selective GluR5-containing receptor agonist robustly potentiated sIPSCs. When tetrodotoxin was included to block action potentials, Ca(2+) uncaging induced a small decrease in the frequency of miniature inhibitory postsynaptic currents, which was not affected by AMPA/kainate receptor antagonists. Our data suggest that an astrocyte-derived, nonsynaptic source of glutamate represents a signaling pathway that can activate neuronal kainate receptors. By modulating the activity of interneurons, astrocytes may play a critical role in circuit function of hippocampus. 相似文献
52.
53.
54.
55.
We report a case of severe systolic anterior motion (SAM) and dynamic left ventricular outflow obstruction after repair of a flail posterior leaflet of the mitral valve. The reason for SAM was found to be due to traction on the pericardial stay sutures placed to expose the surgical field. The SAM and the outflow obstruction were completely resolved by cutting these sutures. Our case demonstrates the contribution of geometric factors in the development of SAM and left ventricular outflow obstruction and emphasizes the need to evaluate the heart in its natural position within the mediastinum. 相似文献
56.
57.
58.
59.
Recurrent terbinafine resistant Trichophyton rubrum infection in a child with congenital ichthyosis 下载免费PDF全文
Louise Schøsler MD Louise Kronborg Andersen MD Maiken Cavling Arendrup MD PhD DMSci Mette Sommerlund MD PhD 《Pediatric dermatology》2018,35(2):259-260
Dermatophytosis in children caused by Trichophyton rubrum is preferably treated with topical or systemic terbinafine. We report the first case of terbinafine resistance in a child with recurrent T. rubrum dermatophytosis and congenital ichthyosiform erythroderma. 相似文献
60.