全文获取类型
收费全文 | 459篇 |
免费 | 24篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 7篇 |
妇产科学 | 14篇 |
基础医学 | 54篇 |
口腔科学 | 25篇 |
临床医学 | 50篇 |
内科学 | 111篇 |
皮肤病学 | 5篇 |
神经病学 | 56篇 |
特种医学 | 4篇 |
外科学 | 52篇 |
综合类 | 4篇 |
一般理论 | 1篇 |
预防医学 | 37篇 |
眼科学 | 6篇 |
药学 | 22篇 |
肿瘤学 | 42篇 |
出版年
2023年 | 5篇 |
2022年 | 2篇 |
2021年 | 8篇 |
2020年 | 10篇 |
2019年 | 13篇 |
2018年 | 9篇 |
2017年 | 6篇 |
2016年 | 10篇 |
2015年 | 16篇 |
2014年 | 18篇 |
2013年 | 32篇 |
2012年 | 24篇 |
2011年 | 17篇 |
2010年 | 16篇 |
2009年 | 14篇 |
2008年 | 37篇 |
2007年 | 30篇 |
2006年 | 25篇 |
2005年 | 29篇 |
2004年 | 18篇 |
2003年 | 21篇 |
2002年 | 17篇 |
2001年 | 7篇 |
2000年 | 7篇 |
1999年 | 3篇 |
1998年 | 5篇 |
1997年 | 2篇 |
1994年 | 2篇 |
1992年 | 7篇 |
1991年 | 2篇 |
1990年 | 3篇 |
1989年 | 5篇 |
1987年 | 6篇 |
1986年 | 9篇 |
1985年 | 11篇 |
1984年 | 8篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1972年 | 1篇 |
1971年 | 2篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有491条查询结果,搜索用时 15 毫秒
481.
482.
483.
BACKGROUND: No longitudinal studies have addressed the effect of late life depression on the physical and mental health status of their informal caregivers. OBJECTIVE: To examine whether a diagnosis of depression in older medical inpatients is associated with the physical and mental health status of their informal caregivers after 6 months, independent of the physical health of the care recipient. DESIGN: Longitudinal observational study with 6-month follow-up. SETTING: Two Montreal acute-care hospitals. SUBJECTS: A sample of 97 cognitively intact medical inpatients aged 65 and over and their informal caregivers, with oversampling of patients with a diagnosis of major or minor depression. METHODS: Patient data included depression (current diagnosis, duration of current diagnosis, severity of symptoms, and history of depression), physical health (severity of illness, comorbidity, premorbid disability), and cognitive impairment. Caregiver data included relationship to patient, co-residence, and the physical and mental health status subscales of the SF-36. Multivariate linear regression analyses were conducted to determine the relationship between patient depression and caregiver 6 month SF-36 physical and mental scores, adjusting for baseline values, patient comorbidity, disability, and other patient and caregiver variables. RESULTS: Patient characteristics included: mean age 79.3, 62% female, 46% major depression, 18% minor depression, 36% no depression. Caregiver characteristics included: 73% female, 35% co-resident spouse, 15% other co-resident relation, 50% not residing with the patient. Results of the multivariate analyses showed that in comparison with caregivers of patients without a current diagnosis of depression, caregivers of those with major depression had a lower mental health score at follow-up (-9.54, 95% CI -16.66, -2.43), even though their physical health was slightly better (5.42 95% CI 0.04, 10.81). CONCLUSIONS: A diagnosis of major depression in older medical inpatients is independently associated with poor mental health in their informal caregivers 6 months later. 相似文献
484.
485.
Marco Fondi Ermanno Rizzi Giovanni Emiliani Valerio Orlandini Luisa Berna Maria Cristiana Papaleo Elena Perrin Isabel Maida Giorgio Corti Gianluca De Bellis Franco Baldi Lenie Dijkshoorn Mario Vaneechoutte Renato Fani 《Research in microbiology》2013,164(5):439-449
Here we report the genome sequence of Acinetobacter venetianus VE-C3, a strain isolated from the Venice Lagoon and known to be able to degrade n-alkanes. Post sequencing analyses revealed that this strain is relatively distantly related to the other Acinetobacter strains completely sequenced so far as shown by phylogenetic analysis and pangenome analysis (1285 genes shared with all the other Acinetobacter genomes sequenced so far). A. venetianus VE-C3 possesses a wide range of determinants whose molecular functions are probably related to the survival in a strongly impacted ecological niche. Among them, genes probably involved in the metabolism of long-chain n-alkanes and in the resistance to toxic metals (e.g. arsenic, cadmium, cobalt and zinc) were found. Genes belonging to these processes were found both on the chromosome and on plasmids. Also, our analysis documented one of the possible genetic bases underlying the strategy adopted by A. venetianus VE-C3 for the adhesion to oil fuel droplets, which could account for the differences existing in this process with other A. venetianus strains. Finally, the presence of a number of DNA mobilization-related genes (i.e. transposases, integrases, resolvases) strongly suggests an important role played by horizontal gene transfer in shaping the genome of A. venetianus VE-C3 and in its adaptation to its special ecological niche. 相似文献
486.
Pilar Flores‐Espinosa Montzerrat Pineda‐Torres Rodrigo Vega‐Sánchez Guadalupe Estrada‐Gutiérrez Aurora Espejel‐Nuñez Arturo Flores‐Pliego Rolando Maida‐Claros Yuriria Paredes‐Vivas Iyari Morales‐Méndez Irma Sosa‐González Angel Chávez‐Mendoza Verónica Zaga‐Clavellina 《American journal of reproductive immunology (New York, N.Y. : 1989)》2014,71(1):61-72
487.
Marcello Maida Fabio Salvatore Macaluso Giuseppe Cabibbo Giuseppe Lo Re Nicola Alessi 《World journal of hepatology》2013,5(6):336-339
A 63-year-old Caucasian man presented with a cholestatic syndrome, renal failure and arthralgias. A laboratory examination revealed high immunoglobulin G (IgG) and IgG4 levels (5.95 g/L; normal range: 0.08-1.4 g/L), pointing to a diagnosis of systemic IgG4-related disease, with definite radiological evidence of biliary and pancreatic expression, and plausible renal, articular, salivary and lacrimal glands involvement. Due to the rarity of the condition, there are currently no random control trials to point to the optimal therapeutic approach. The patient has been on steroid therapy with the subsequent introduction of azathioprine, with a complete resolution of all symptoms, a rapid reduction to normalization of all blood tests, and a complete regression of the radiological picture. Our experience underlines the complexity of IgG4-related disease and its variable and sometimes progressive presentation, while pointing out the need for a careful and complete assessment for possible multi-organ involvement. 相似文献
488.
489.
490.
Kit Chong BBMed Jack Maida BBioMed MD Hwa Ian Ong MBChB David Proud MBBS James Lin BBMed Adele Burgess MBBS BMedSci Alexander Heriot MA MB BChir MBA MD Philip Smart MBBS DMEDSCI Helen Mohan PhD DRCOG Dip Clin Leadership MB BCh BAO BMedSci 《ANZ journal of surgery》2023,93(10):2314-2336