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Joanna d'Arc Lyra Batista Maria de Fátima Pessoa Milit?o de Albuquerque Marcela Lopes Santos Demócrito de Barros Miranda-Filho Heloísa Ramos Lacerda Magda Maruza Libia Vilela Moura Isabella Coimbra Ricardo Arraes de Alencar Ximenes 《Revista do Instituto de Medicina Tropical de S?o Paulo》2014,56(2):127-132
Despite the effectiveness of combination antiretroviral therapy in the
treatment of people living with HIV/AIDS (PLWHA), nonadherence to medication has
become a major threat to its effectiveness. This study aimed to estimate the
prevalence of self-reported irregular use of antiretroviral therapy and the factors
associated with such an irregularity in PLWHA. A cross-sectional study of PLWHA who
attended two referral centers in the city of Recife, in Northeastern Brazil, between
June 2007 and October 2009 was carried out. The study analyzed socioeconomic factors,
social service support and personal habits associated with nonadherence to
antiretroviral therapy, adjusted by multivariable logistic regression analysis. The
prevalence of PLWHA who reported irregular use of combination antiretroviral therapy
(cART) was 25.7%. In the final multivariate model, the irregular use of cART was
associated with the following variables: being aged less than 40 years (OR =
1.66, 95%-CI: 1.29-2.13), current smokers (OR = 1.76, 95%-CI: 1.31-2.37) or
former smokers (OR = 1.43, 95%-CI: 1.05-1.95), and crack cocaine users (OR
= 2.79, 95%-CI: 1.24-6.32). Special measures should be directed towards each
of the following groups: individuals aged less than 40 years, smokers, former smokers
and crack cocaine users. Measures for giving up smoking and crack cocaine should be
incorporated into HIV-control programs in order to promote greater adherence to
antiretroviral drugs and thus improve the quality of life and prolong life
expectancy. 相似文献
25.
Kiran Kumar Mudnakudu Nagaraju Magda Babina Margitta Worm 《Experimental dermatology》2013,22(11):742-747
Proteasome inhibition (PI) has been reported to interfere with antibody‐driven autoimmune diseases. The impact of PI on the allergic immune response and on skin diseases like atopic dermatitis (AD) has not been thoroughly explored, however. Here, we examined whether the PI bortezomib interferes with the allergic immune response and the severity of AD by using an established mouse model of allergen‐driven dermatitis, to which bortezomib was applied after the establishment of systemic sensitization to ovalbumin. The treatment indeed resulted in a remarkable decrease in total and allergen‐specific plasma cells/antibody‐secreting cells, as evidenced by flow cytometry and ELISpot, respectively. This was accompanied by rapid reductions in serum antibody titres, including a prominent reduction of the IgE isotype. CD4+ and CD8+ cells were greatly diminished in lesional skin on immunohistological staining. The impressive effects at the level of immune modulation did not result in any improvement in the eczema, however. Following up on this unexpected result, we found that the skin itself was susceptible to bortezomib, by which it was instructed to lower the expression of critical skin barrier genes, especially transglutaminase‐1 and filaggrin. Together, bortezomib eliminates plasma cells and decreases immunoglobulin responses, including allergenic IgE. Although anti‐inflammatory effects are detectable in the skin, counter‐regulatory effects from PI on resident skin cells likely undermine improvement in the eczema. These results caution against the therapeutic use of bortezomib for inflammatory skin disorders, which are characterized by inherently impaired barrier function, especially AD. 相似文献
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Protocol for digital intervention for effective health promotion of small children—A cluster randomized trial
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28.
Beatriz Deoti e Silva Rodrigues Raniere dos Santos Magda Maria Profeta da Luz Flávia Chaves e Silva Igor Guedes Nogueira Reis 《Clinical journal of gastroenterology》2016,9(6):341-344
Acute esophageal necrosis (AEN) or “black esophagus” is a rare condition presented by patients with critical state of health and characterized by a darkened esophagus, usually the distal third, in upper digestive endoscopy. The main clinical manifestation is upper gastrointestinal bleeding and there may be abdominal pain, dysphagia, nausea, vomiting, fever and syncope associated. The diagnosis depends on clinical suspicion and performing endoscopy, the biopsy not being required. In this article we present a case of a patient who had lots of comorbidities and developed AEN during a post-operative period, and discuss the importance of AEN in an increasingly ageing population. 相似文献
29.
Fernando Pea Benito Ordaz Hugo Balleza‐Tapia Ramn Bernal‐Pedraza Abraham Mrquez‐Ramos Liliana Carmona‐Aparicio Magda Giordano 《Hippocampus》2010,20(1):78-96
Early cognitive deficit characteristic of early Alzheimer's disease seems to be produced by the soluble forms of β‐amyloid protein. Such cognitive deficit correlates with neuronal network dysfunction that is reflected as alterations in the electroencephalogram of both Alzheimer patients and transgenic murine models of such disease. Correspondingly, recent studies have demonstrated that chronic exposure to βAP affects hippocampal oscillatory properties. However, it is still unclear if such neuronal network dysfunction results from a direct action of βAP on the hippocampal circuit or it is secondary to the chronic presence of the protein in the brain. Therefore, we aimed to explore the effect of acute exposure to βAP25–35 on hippocampal network activity both in vitro and in vivo, as well as on intrinsic and synaptic properties of hippocampal neurons. We found that βAP25–35, reversibly, affects spontaneous hippocampal population activity in vitro. Such effect is not produced by the inverse sequence βAP35–25 and is reproduced by the full‐length peptide βAP1–42. Correspondingly βAP25–35, but not the inverse sequence βAP35–25, reduces theta‐like activity recorded from the hippocampus in vivo. The βAP25–35‐induced disruption in hippocampal network activity correlates with a reduction in spontaneous neuronal activity and synaptic transmission, as well as with an inhibition in the subthreshold oscillations produced by pyramidal neurons in vitro. Finally, we studied the involvement of Fyn‐kinase on the βAP25–35‐induced disruption in hippocampal network activity in vitro. Interestingly, we found that such phenomenon is not observed in slices obtained from Fyn‐knockout mice. In conclusion, our data suggest that βAP acutely affects proper hippocampal function through a Fyn‐dependent mechanism. We propose that such alteration might be related to the cognitive impairment observed, at least, during the early phases of Alzheimer's disease. © 2009 Wiley‐Liss, Inc. 相似文献
30.
Maria T. Rinaudo Magda Curto Ivana Rabbone Marco Piccinini Renato Bruno Silvia Mioletti Silvia Gamba 《Journal of diabetes and its complications》1994,8(4):221-225
In circulating lymphocytes from patients with non-insulin-dependent diabetes mellitus (NIDDM) subnormal pyruvate dehydrogenase (PDH) activity returns to normal following patient treatment with sulfonylurea (gliclazide*, 80 mg twice daily/5 weeks). Moreover, in vitro in cells from diabetic patients exposed to insulin at 50 μU/mL PDH activation also occurs; in cells of controls the same happens for insulin at 5 μU/mL, whereas at 50 μU/mL inhibition takes place. Therefore, the low PDH activity in cells of NIDDM patients might be caused by defective insulin control on the enzyme and its recovery in gliclazide-treated patients by drug-mediated removal of the defect. The validity of the hypothesis was verified in this study where cells of NIDDM patients before and after gliclazide treatment were exposed, in vitro, to insulin at 5 and 50 μU/mL and then tested for PDH activity. In such conditions, the profile of PDH behavior in treated patients was no longer comparable to that in untreated patients but closer to that in euglycemic controls, thus supporting the view that the recovery of PDH activity in NIDDM patients following gliclazide treatment might be the expression of an additional effect that the drug would have in these patients, aimed to renew cell responsiveness to insulin. 相似文献