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911.
肿瘤浸润淋巴细胞及重组白细胞介素2治疗原发性肝细胞癌 总被引:1,自引:1,他引:0
目的探讨联合应用肿瘤浸润性淋巴细胞(tumorinfitratinglymphocytes,TIL)和重组白细胞介素2(rIL2)治疗对原发性肝细胞癌(primaryhepatocelularcarcinoma,PHCC)术后患者细胞免疫功能的影响和其临床疗效。方法对16例PHCC术后患者进行了TIL和rIL2治疗,12例从肝动脉插管输入,4例从门静脉插管输入。结果TIL治疗后16例患者外周血白细胞介素2(IL2),T细胞亚群及比率均有不同程度上升;肿瘤坏死因子(TNF),白细胞介素6(IL6)多有不同程度下降。随访6~24个月,14例肝癌根治性切除术患者,肿瘤无复发迹象,1例肝癌根治切除术患者TNF上升了8IU,该患者治疗8个月后死于肝功能衰竭;1例肝癌姑息性切除,残癌无水酒精注射病人,TIL治疗18个月后肿瘤直径扩大2cm。结论TIL治疗对提高PHCC术后患者抗肿瘤细胞免疫功能,防止肿瘤复发,抑制残瘤生长,延长患者生存期具有一定作用。 相似文献
912.
913.
How should we manage children after mild head injury? 总被引:1,自引:0,他引:1
There are many controversies concerning the management of children after mild head injury. Most of these patients achieve
a full recovery without medical or surgical intervention. A small percentage of them deteriorate owing to intracranial complications.
The goal of this study was to identify significant factors that might allow the identification of patients at risk of subsequent
deterioration. Its secondary goal was to establish a clinical protocol for the management of mild head injuries in children.
We retrospectively reviewed the records of 166 children and adolescents with head trauma who had Glasgow Coma Scale (GCS)
or Children Coma Scale (CCS) scores of 13–15 at the time of admission. The patients were divided into five age categories:
babies younger than 1 year, children 1–3, 4–6, and 7–14 years old, and adolescents 15–17 years of age. The largest age group
consisted of children 7–14 years old (83 cases). There was a male predominance (2:1). The main causes of injury were traffic
accidents (55 cases) and falls (53 patients). Neurosurgical procedures were required in 93 of the 166 patients (56%). The
most common intracranial lesion was subdural and epidural hematoma (60 cases). In 26 children (15.6%) diffuse brain swelling
was the only lesion. A skull fracture was found in 103 cases and was accompanied by epidural hematoma (HED) in 19 cases (18%)
and by subdural hematoma (HSD) in 12 cases (12%). However, the 63 children without a fracture also included 18 (29%) who had
HSD and 11 (17%) who had HED. In our population 165 (99%) of the patients obtained a very good or good result. None was left
severely disabled or in a vegetative state. One patient with GCS 13 died of an infection. We concluded that skull X-ray examination
is not sufficient to rule out intracranial hematoma. We recommend CT scanning and admission to hospital for 24-h observation
for all children with minor head injury, because of the risk of delayed hematoma.
Received: 8 September 1999 相似文献
914.
耳部原发性横纹肌肉瘤的临床与病理特征 总被引:1,自引:0,他引:1
目的 探讨耳部原发性横纹肌肉瘤的临床及病理特征及其与婴儿横纹肌纤维肉瘤、原始神经外胚瘤、恶性横纹肌样瘤等肿瘤的鉴别诊断。方法 用光学显微镜和免疫组织化学以及肉眼观察8例耳部原发性横纹肌肉瘤的临床病理学特征。结果 8例中男性7例,女性1例,平均年龄7.4岁,其中胚胎性横纹肌肉瘤7例,葡萄型横纹肌肉瘤1例。免疫组织化学检查阳性率分别为:Vimentin及Myoglobin100%,Desmin75%,Actin82%。结论 耳部原发性横纹肌肉瘤和其他部位的软组织横纹肌肉瘤相比,组织学上并无特殊,但临床及病理形态学诊断却较困难,常需免疫组织化学标记帮助方能确诊。 相似文献
915.
916.
917.
918.
Dan Lin Haiyang Zhang Rui Liu Ting Deng Tao Ning Ming Bai Yuchong Yang Kegan Zhu Junyi Wang Jingjing Duan Shaohua Ge Bei Sun Guoguang Ying Yi Ba 《Molecular oncology》2021,15(12):3430
Fatty acid oxidation (FAO) plays a vital role in drug resistance in cancer cells. Carnitine palmitoyltransferase 1A (CPT1A), a key enzyme of FAO, is widely recognized as an emerging therapeutic target. Here, we confirmed that CPT1A was heterogeneously expressed in colon cancer cells, with a high expression in oxaliplatin‐resistant cells but low expression in oxaliplatin‐sensitive cells, and expression could be increased by oxaliplatin stimulation. In addition, we verified that CPT1A was more highly expressed in colon cancer tissues than in noncancerous tissues. Silencing CPT1A by siRNA or etomoxir, a specific small‐molecule inhibitor of CPT1A, could reverse the sensitivity of drug‐resistant colon cancer cells to oxaliplatin. Subsequently, the combination of oxaliplatin with CPT1A inhibition promoted apoptosis and inhibited proliferation. In addition, exosomes were generated with the iRGD peptide on the surface, which showed highly efficient targeting compared with control exosomes in vivo. Furthermore, we loaded and therapeutically applied iRGD‐modified exosomes with siCPT1A to specifically deliver siCPT1A into tumours to suppress FAO. As a consequence, iRGD‐modified exosomes showed the significant inhibition of CPT1A in tumour tissues and exhibited the ability to reverse oxaliplatin resistance and inhibit tumour growth by inhibiting FAO with high safety in vivo. 相似文献
919.
Bereavement can lead to prolonged grief disorder (PGD) as well as episodes of major depression. Studies on the prevalence of PGD and its differences from postbereavement depression have not been conclusive. This study compared the correlates of depression and prolonged grief (PG) symptoms in a population-based random sample (N = 535) using the Beck Depression Inventory, Inventory of Complicated Grief–Revised, Anxiety Sensitivity Index (ASI), and Adult Separation Anxiety Questionnaire (ASAQ). Correlates of PG and depressive symptoms were examined using linear regression in 328 bereaved respondents. The prevalence of probable PGD based on PGD-2009 criteria was 3.0% among bereaved respondents and 1.9% in the total sample. PG was related to bereavement-related features including sex of the deceased, β = − .110, p = .026; time since loss, β = − .179, p = .001; the number of lifetime losses experienced, β = .157, p = .016; and perceived closeness with the deceased, β = .214, p < .001. Only lower income of the bereaved predicted depression, β = − .139, p = .018. In women, but not in men, the loss of a male family member (i.e., brother or son) was a significant predictor of PG symptoms, β = − .180, p = .006. The results confirm the qualitative distinction between depression and PG in a nonclinical sample and show that PG is mainly related to the intrinsic and extrinsic characteristics of the deceased or of death, whereas depression relates only to the characteristics of the bereaved person. 相似文献
920.
Rocío Aller Conrado Fernández-Rodríguez Oreste lo Iacono Rafael Bañares Javier Abad José Antonio Carrión Carmelo García-Monzón Joan Caballería Marina Berenguer Manuel Rodríguez-Perálvarez José López Miranda Eduardo Vilar-Gómez Javier Crespo Miren García-Cortés María Reig José María Navarro Rocío Gallego Joan Genescà Manuel Romero-Gómez 《Gastroenterologia y hepatologia》2018,41(5):328-349