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排序方式: 共有3454条查询结果,搜索用时 15 毫秒
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Predisposing factors for severe, uncontrolled hypertension in an inner-city minority population. 总被引:24,自引:0,他引:24
S Shea D Misra M H Ehrlich L Field C K Francis 《The New England journal of medicine》1992,327(11):776-781
34.
Immunomodulation of autoimmune and inflammatory diseases with intravenous immunoglobulin 总被引:2,自引:0,他引:2
Ephrem A Misra N Hassan G Dasgupta S Delignat S Duong Van Huyen JP Chamat S Prost F Lacroix-Desmazes S Kavery SV Kazatchkine MD 《Clinical and experimental medicine》2005,5(4):135-140
Abstract Intravenous immunoglobulin (IVIg) has been used in the treatment of primary and secondary antibody deficiencies for over two
decades. Since the early 1980s, the therapeutic efficacy of IVIg has been established in idiopathic thrombocytopenic purpura,
Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis, dermatomyositis and Kawasaki
syndrome, and the prevention of graft versus host disease in recipients of allogeneic bone marrow transplants. Its use has
also been reported in a large number of other autoimmune and systemic inflammatory conditions. In this review, we discuss
the mechanisms by which IVIg exerts immunomodulatory effects in immune pathologies. 相似文献
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Peresters dissociate thermally to alkoxy and acyloxy radicals. The acyloxy radical may dissociate further into an aryl radical and carbon dioxide. Alternatively they may break into these products in a single stage reaction. The decomposition of tert-butyl perbenzoate has been studied and it has been shown that the primary products of the dissociation of this ester are alkoxy and acyloxy radicals. The polymerization of styrene, using tert-butyl perbenzoate, tert-butyl percinnamate and tert-butyl percrotonate has been studied at 120 ± 1°C. It has been shown that the rate of polymerization is proportional to the square root of the initiator concentration and the 3/2 power of the monomer concentration. 相似文献
37.
OBJECTIVE: In tuberculous meningitis (TBM) blood flow may be altered due to associated vasculitis, hydrocephalus and raised intracranial pressure. Electroencephalography (EEG) and single photon emission computed tomography (SPECT) provide information about electrical activity and regional cerebral blood flow respectively. This study aims at the correlation of EEG and SPECT changes in patients with TBM. METHOD: Sixteen patients with TBM whose age ranged between 5 and 62 years and 3 of whom were females were subjected to clinical, radiological (CT and/or MRI), EEG and SPECT studies using 99mTc ethylene cystine dimer (ECD). Ten patients were in stage III and 3 each in stage II and stage I meningitis. Cranial CT scan was carried out in 15 and MRI in 4 patients. Hydrocephalus was present in 9, infarction in 7 and tuberculoma in 5 patients. RESULTS: SPECT studies were abnormal in all except 2 patients revealing basal ganglionic hypoperfusion in 14 and focal cortical hypoperfusion in 9 patients. The EEG was abnormal in 11 patients which included delta slowing in 5, theta slowing in 6, frontal intermittent rhythmic delta activity (FIRDA) in 3 and epileptiform discharges in 2 patients. All the patients with abnormal EEG had abnormal SPECT study except 1. In 4 patients, EEG was normal although there was subcortical hypoperfusion on SPECT. In spite of high frequency of focal cortical hypoperfusion (9 patients), EEG revealed focal abnormality in 3 patients only. CONCLUSION: It can be concluded that the SPECT reveals more frequent abnormalities compared to EEG and CT scan. Cortical hypoperfusion with or without basal ganglia hypoperfusion is associated with FIRDA and diffuse delta slowing on EEG. 相似文献
38.
Vitamin B12 deficiency neurological syndromes: a clinical,MRI and electrodiagnostic study 总被引:6,自引:0,他引:6
BACKGROUND: Vegetarianism is an important cause of vitamin B12 deficiency, especially in countries like India. We managed 17 patients with neurological syndrome due to vitamin B12 deficiency in a tertiary care referral teaching hospital which caters to relatively affluent population. AIM: To evaluate neurophysiological and MRI changes in patients presenting with vitamin B12 deficiency neurological syndrome and interpret these is the light of reported autopsy findings. SETTING: Tertiary care referral teaching hospital. METHODS: Patients with vitamin B12 deficiency neurological syndrome diagnosed by low serum vitamin B12 and/or megaloblastic bone marrow were subjected to clinical evaluation and spinal MRI. The neurophysiological tests included nerve conduction studies, tibial somatosensory evoked potential (SEP), motor evoked potential (MEP) and visual evoked potential (VEP) studies. The recovery was defined on the basis of 6 months Barthel Index score into complete, partial or poor. RESULTS: There were 17 patients with vitamin B12 deficiency neurological syndrome, 3 were females and 12 lactovegetarian. The clinical syndrome was that of myelopathy in 8, myeloneuropathy in 5, dementia myelopathy in 3 and neuropathy in 1 patient. All the patients had impaired joint position and vibration sensation in the lower limbs and 4 had in upper limbs as well. Lower limbs were spastic in 13 and upper limbs in 2 patients. Spinal MRI revealed T2 hyperintensity in cervicodorsal region in 6 and cord atrophy in 3 patients. Sural nerve conduction was abnormal in 8 and peroneal conduction in 5 patients. In one patient all sensory nerve conductions were unrecordable but motor conductions were normal. Tibial SEP was abnormal in 12 out of 15 and lower limb MEP in 8 out of 12 patients. P100 latency of VEP was prolonged in 7 out of 13 patients. Right to left asymmetry was present in tibial SEP in 4 and VEP in 2 patients. At 6 months followup 2 patients improved completely, 7 partially and 3 had poor recovery. Clinical recovery correlated with MEP but not with SEP or MRI changes. CONCLUSION: The evoked potential and MRI changes in vitamin B12 deficiency neurological syndrome are consistent with focal demyelination of white matter in spinal cord and optic nerve. Myelopathic presentation is commoner and SEP is more frequently abnormal. The outcome at 6 months correlated with MEP changes. 相似文献
39.
Suryanarayana Veluvarti Tulasiram Prathapam Prabhudas Krishnam Setty Misra Laxmi Dutt Natarajan Chitattor 《Virus genes》1998,16(2):167-172
Vaccination is the only pragmatic approach to control foot and mouth disease in India. Strict quality control measures are
essential to supply potent vaccine to the field application, in addition to monitoring the performance of the vaccine in the
field. During the process of monitoring, an outbreak of FMD in vaccinated animals caused by type “O” virus in Tanjavur district
of Tamil Nadu and a type “O” virus from unvaccinated herd of Karnataka were studied. Field isolates and vaccine virus were
sequenced and analyzed. Data indicated that the virus from the outbreak in vaccinated cattle was a variant which could escape
neutralization by antibodies against vaccine virus.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
40.
The essential oil of a strain of PERILLA OCIMOIDES from Bangladesh, cultivated at Lucknow, after GC-MS investigations afforded rosefuran ( 1) as the major constituent (58%) along with 17 others including beta-caryophyllene, perilla ketone ( 2), perillene, alpha-cedrene, germacrene-D, and isobis-abolene. 相似文献