儿童对口腔诊室环境选择的调查分析

目的调查和分析儿童对口腔诊室环境的选择,为改善口腔诊室环境提供依据。方法选择2019年9—12月至青岛大学附属青岛市口腔医院儿童口腔科就诊的110名儿童作为研究对象,进行问卷调查,使用χ2检验对结果进行统计分析。结果共计回收有效调查问卷107份,问卷回收率97%,被调查儿童喜欢粉色和蓝色墙壁的诊室(61.68%),室内悬挂卡通画(57.94%)并布置玩具(61.68%),大部分儿童对诊室内特殊气味不反感(62.62%),喜欢诊室内有橘子精油味道(52.34%);在治疗中喜爱的娱乐是看卡通片(61.68%),希望医护人员着白色服装(51.40%);由女医生治疗(68.22%),大多数儿童希望就诊时有家人陪伴(62.62%)。卡方检验显示:在诊室环境中,墙壁的颜色、室内装饰、布置、治疗时的娱乐方式、医护着装颜色、诊疗医生性别、治疗时是否需要家长陪伴这7方面中,学龄前和学龄期儿童的选择结果差异具有统计学意义(P<0.05),初、复诊儿童在诊室墙壁颜色、室内装饰这2方面中的选择结果差异具有统计学意义(P<0.05),不同性别儿童在诊室环境选择上差异无统计学意义(P>0.05)...     

异丙酚预处理对拟阿尔茨海默病模型大鼠神经行为学和神经原纤维缠结及胶质纤维酸性蛋白的影响

目的:观察异丙酚预处理对拟阿尔茨海默病(AD)模型大鼠的神经行为学及海马损伤神经原纤维缠结(NFT)和胶质纤维酸性蛋白(GFAP)表达的影响,分析异丙酚的脑保护作用。方法:大鼠海马CA1区微量注射冈田酸(OA),建立拟AD大鼠模型。异丙酚预处理组大鼠于拟AD模型制作前30min,腹腔注射异丙酚100mg/kg。并以Morris水迷宫实验观察大鼠行为学变化,Bielschowsky染色观察NFT及免疫组织化学方法观察GFAP表达的变化。结果:与对照组大鼠相比,模型组大鼠学习记忆能力显著降低;Bielschowsky染色观察海马CA1区域出现大量NFT的特征性病理变化,GFAP免疫组织化学阳性细胞明显增多。与模型组大鼠相比,异丙酚预处理组大鼠学习记忆能力明显提高;海马CA1区NFT明显减少或消失,GFAP免疫组织化学阳性细胞明显减少。结论:拟AD模型建立前30min异丙酚预处理能改善拟AD模型大鼠学习记忆能力,降低NFT和GFAP的表达,有明显的脑保护作用。     

注射用门冬氨酸洛美沙星过敏诱发心肌梗死

患者男,66岁。于2005年1月18日因直肠癌入院。既往有30年吸烟史,无呼吸系统疾病、高血压及糖尿病史,无药物过敏史。入院后心电图正常,血常规均正常,青霉素皮试(-)。1月20日行直肠癌根治术。术后给予0.9%氯化钠注射液250mL 头孢哌酮/舒巴坦钠注射液(新浩欣,0.75g/支)3.75g;5%葡萄糖注射液250mL 门冬氨酸洛美沙星0.4g(星洛)1次/d静滴预防感染。1月23日查体:T37.0℃,BP140/100mmHg(1mmHg=0.133kPa),P82次/min,R18/min。术区洁,引流管通畅,胃液量200mL,淡黄色,腹腔引流100mL,淡黄色,肛管引出10mL暗红色液体,尿量为1500mL,淡黄色,受压部位…     

COPD患者血清CTRP9、FKN水平测定的临床意义

目的探讨血清CTRP9、FKN与COPD患者肺功能、炎症反应的相关性,分析2种因子联合检测对AECOPD的预测价值。方法选择某医院呼吸内科2018年6月1日-2020年1月1日收治的COPD患者118例,其中处于稳定期患者75例(稳定组),急性加重期患者43例(加重组),随机选择同期健康体检的非COPD患者40例(对照组)。对3组研究对象进行肺功能检测,记录FEV1%pred、FEV1/FVC,测定血清TNF-α、IL-1β、CTRP9、FKN水平。绘制ROC曲线,评价血清CTRP9、FKN和2者联合检测对AECOPD的预测价值。结果对照组、稳定组和加重组血清CTRP9[(87.42±9.07)pg/mL、(109.45±10.35)pg/mL、(166.10±13.54)pg/mL]、FKN[(189.67±18.63)ng/L、(425.38±28.23)ng/L、(561.81±37.96)ng/L]、IL-1β[(1.31±0.28)ng/L、(3.16±0.57)ng/L、(4.44±0.72)ng/L]、TNF-α[(1.28±0.37)ng/L、(3.21±0.66)ng...     

Linear structural features of Wilson’s disease and its correlation with neurological symptoms

To measure the linear structure of the brain in patients with Wilson’s disease (WD) and analyze its correlation with neurological symptoms. A total of 174 patients diagnosed with WD were enrolled. According to the type of clinical presentation, the patients with WD were divided into two groups: neurological (NWD) and hepatic (HWD). Sixty healthy volunteers were assigned to a control group. All patients with WD and healthy controls underwent brain magnetic resonance imaging (MRI). The severity of the neurological symptoms was assessed using the Burke Fahn Marsden Movement subscale (BFM-M). Linear brain measurements were performed using T1-weighted MRI scans of all the patients, and the correlation between these linear indices and BFM-M score was investigated. The Huckman index, third ventricle width, and sulcus width of the NWD group were significantly higher than those of the HWD and control groups (P < .05). The frontal horn index, ventricular index, and lateral ventricular body width index of the NWD group were significantly lower than those of the HWD and control groups (P < .05). The Huckman index and third ventricle width of the HWD group were higher than those of the control group (P < .05), whereas the body width index of the lateral ventricle was lower than that of the control group (P < .05). The BFM-M score correlated with the Huckman index (r = 0.29, P < .05), third ventricle width (r = 0.426, P < .001), and lateral ventricular body width index (r = −0.19, P < .05). This study demonstrated significant changes in the linear structure of patients with WD. Linear brain measurement analysis could be used as a potential method to assess the severity of neurological symptoms in WD.     

镁离子对妊娠期高血压疾病孕鼠胎盘电镜影响的观察

目的：探讨给孕鼠不同含量镁离子鼠粮喂养,观察妊娠期高血压疾病孕鼠的胎盘形态学有何变化。方法：将SD孕鼠于孕龄1-3d随机分成三组,正常孕鼠组、低镁妊高征组、高镁妊高征组,分别给与正常鼠粮、低镁鼠粮、正常鼠粮高镁灌胃喂养,于孕龄19d解剖取胎盘组织进行电镜观察。结果：高镁妊高征组胎盘超微结构与正常孕鼠相近未见明显改变。低镁妊高征组与正常组比较有明显的改变。结论：孕期补镁可逆转妊高征胎盘组织变化,避免妊娠期高血压疾病的发生。     

PDCA循环法在检验科抽血室护生实习教学管理中的应用

目的　探讨PDCA循环法在提高门诊抽血室护生教学管理中的应用效果。方法　选取2019年4月至2019年9月到检验科实习的护生48人,按教学方法的不同分为对照组和观察组各24人。两组患者在性别、年龄、学历、认知等无差异(P>0.05),回顾分析影响培训效率低下的因素,列出影响因素的类型,制定相应的对策并落实执行。结果　实验组在采用PDCA循环法后,其教学满意率、护生出科成绩、明显高于观察组(P<0.05)。结论　PDCA循环法在提升抽血室护生教学满意率有实践指导意义,同时有利于护生充分掌握临床知识。我科将持续改进用于教学管理。