排序方式: 共有37条查询结果,搜索用时 0 毫秒
31.
MITSUHIRO TAMBO KIYOHIDE FUJIMOTO TAKESHI INOUE ATSUSHI TOMIOKA YOZO TANAKA YOSHIHIKO HIRAO MASAHIDE YOSHIKAWA 《International journal of urology》2004,11(7):563-566
A 29-year-old Japanese man with a history of travel to Africa visited the Department of Urology, Nara Medical University complaining of intermittent asymptomatic gross hematuria over a period of 30 months. As he was suspected of being infested with schistosomal parasites based on his past history of swimming in Malawi Lake during his stay in Egypt two years previously, we examined his urine microscopically for the presence of Schistosoma haematobium eggs and diagnosed him as having urinary schistosomiasis. Endoscopic examination revealed multiple small erythematous torose lesions on the right posterior wall of the urinary bladder. Since he was treated by oral administration of praziquantel every 6 h for 2 days (total daily dose of 2400 mg), a specific anthelmintic drug for schistosomiasis, the disease has been successfully kept under control without significant lesions in the bladder mucosa after the immediate disappearance of the eggs in his urine. 相似文献
32.
TAKASHI KOBAYASHI HIROSHI OKUNO MITSUHIRO TACHIBANA NORIKO MORI HIROSHI YOSHIDA SHINGO YAMAMOTO TOSHIYUKI KAMOTO AKITO TERAI OSAMU OGAWA 《International journal of urology》2003,10(11):607-609
We report a case in which a living related renal transplantation was successfully performed for end-stage renal disease that had progressed after a liver transplantation from a brain-dead donor for liver cirrhosis associated with type C hepatitis. Because the transplanted liver function had been excellent with the use of tacrolimus and mycophenolate mofetil, the same immunosuppressive agents with prednisolone were employed for the renal transplantation. Both grafts are functioning well without recurrence of hepatitis at 10 months after the renal transplantation. From our experience, renal transplantation should not be contraindicated even if the patient has undergone liver transplantation or has hepatitis C viral infection. 相似文献
33.
C. SATOH J. V. NEEL A. MIURA† C. UENO H. ARAKAWA H. OMINE K. GORIKI ‡ M. FUJITA 《Annals of human genetics》1985,49(1):11-22
The frequency of inherited variations in thermostability was investigated in a series of seven enzymes in a Japanese population. Among a total of 5930 determinations, nine variants were encountered. In each instance one parent exhibited a similar finding. It is suggested that this procedure should detect a high proportion of the variants of these enzymes characterized by amino acid substitutions not altering molecular charge. Failure to detect more such thermostability variants is interpreted to mean that electrophoresis not only detects amino acid substitutions altering molecular charge but also a considerable proportion of those that do not alter charge. 相似文献
34.
TAKAKAZU HIGUCHI KAZUHIKO NOMOTO HIRAKU MORI HARUO NIIKURA MITSUHIRO OMINE KAZUHIKO SEKIYAMA MAKOTO YOSHIBA RIKIYA FUJITA 《Journal of gastroenterology and hepatology》1997,12(3):237-242
We report on a case of primary hepatic lymphoma that developed in a patient with chronic hepatitis C. Given that Japan is an area endemic for both hepatitis B and C viruses, we reviewed 51 Japanese cases of primary hepatic lymphoma, addressing the question as to whether the Japanese cases have unique characteristics and whether there is a causal relationship to the presence of chronic liver disease. Primary hepatic lymphoma most commonly affected middle-aged males. Presenting symptoms and physical findings were non-specific. Aminotransferases tended to stay in the low range compared with marked increases in lactate dehydrogenase. Sixteen patients (31%) had chronic liver disease, eight had liver cirrhosis and eight had chronic hepatitis, suggesting that there is a possible aetiological link between chronic liver disease and primary hepatic lymphoma. 相似文献
35.
AKIHIKO SAITO TETSURO TAKEDA HITOMI HAMA YUKO OYAMA KIYOKO HOSAKA ATSUHITO TANUMA RYOHEI KASEDA MITSUHIRO UENO SHINICHI NISHI SHINYA OGASAWARA FUMIO GONDAIRA YOSHIKI SUZUKI FUMITAKE GEJYO 《Nephrology (Carlton, Vic.)》2005,10(S2):S26-S31
SUMMARY: Megalin is an endocytic receptor on the apical membranes of proximal tubule cells (PTC) in the kidney, and is involved in the reabsorption and metabolism of various proteins that have been filtered by glomeruli. Patients with diabetes, especially type 2 diabetes, or metabolic syndrome are likely to have elevated serum levels of advanced glycation end products, liver-type fatty acid binding protein, angiotensin II, insulin and leptin, and renal metabolism of these proteins is potentially overloaded. Some of these proteins are themselves nephrotoxic, while others are carriers of nephrotoxic molecules. Megalin is involved in the proximal tubular uptake of these proteins. We hypothesize that megalin-mediated metabolic overload in PTC leads to compensatory cellular hypertrophy and sustained Na+ reabsorption, causing systemic hypertension and glomerular hyperfiltration via tubuloglomerular feedback, and named this as 'protein metabolic overload hypothesis'. Impaired metabolism of bioactive proteins such as angiotensin II and insulin in PTC may enhance hypertrophy of PTC and/or Na+ reabsorption. Sleep apnoea syndrome, a frequent complication of diabetes and metabolic syndrome, may cause renal hypoxia and result in relative overload of protein metabolism in the kidneys. The development of strategies to identify patients with diabetes or metabolic syndrome who are at high risk for renal metabolic overload would allow intensive treatment of these patients in an effort to prevent the development of nephropathy. Further studies on the intracellular molecular signalling associated with megalin-mediated metabolic pathways may lead to the development of novel strategies for the treatment of nephropathies related to diabetes and metabolic syndrome. 相似文献
36.
AKIO MATSUBARA HIROAKI YASUMOTO JUN TEISHIMA MITSUHIRO SEKI KOJI MITA YASUHISA HASEGAWA TATEKI YOSHINO MASAO KATO TSUGURU USUI 《International journal of urology》2006,13(8):1098-1102
Our aim was to investigate whether or not men with lower urinary tract symptoms are at increased risk of prostate cancer. A total of 3511 men aged 50-79 years who underwent mass screening for prostate cancer between 2002 and 2004 for the first time, and completed the International Prostate Symptom Score (IPSS) questionnaire at the time of the prostate specific antigen (PSA) test, were enrolled in the present study. All men with PSA values greater than 4.0 ng/mL were advised and encouraged to undergo transrectal systematic sextant biopsy. The number of cancers subsequently detected was compared between men with IPSS scores of 0-7 and 8-35. Of the 3511 men, 219 (6.2%) had PSA values greater than 4 ng/mL, 178 (5.1%) underwent biopsy, and 51 (1.5%) were found to have prostate cancer. Although the PSA positivity rate for men with IPSS scores of 8-35 was significantly higher than that in the 0-7 group, there were no significant intergroup differences in the cancer detection rates for biopsied men and for total screened subjects. Multivariate logistic regression analysis revealed that prostate volume was the dominant predictor for the detection of prostate cancer, followed by PSA level, but the IPSS made no significant contribution. No significant difference was noted in the IPSS scores between men with cancer and the others of the same age group. Symptomatic Japanese men are not at higher risk of prostate cancer despite their higher PSA values compared with asymptomatic men of the same age group. 相似文献
37.
AKIKO UEDA-TATSUMOTO M.D. SEIJI FUKAMIZU M.D. MITSUHIRO NISHIZAKI M.D. Ph .D.† HARUMIZU SAKURADA M.D. Ph .D. MASAYASU HIRAOKA M.D. Ph .D.‡ 《Pacing and clinical electrophysiology : PACE》2009,32(11):1481-1484
Acute lead perforation is one of the major complications associated with implantable cardioverter defibrillator (ICD) implantation. We describe a case with repetitive inappropriate ICD discharges due to noise oversensing as the first sign of lead perforation. 相似文献