全文获取类型
收费全文 | 4727998篇 |
免费 | 333384篇 |
国内免费 | 10135篇 |
专业分类
耳鼻咽喉 | 67337篇 |
儿科学 | 156747篇 |
妇产科学 | 130789篇 |
基础医学 | 672140篇 |
口腔科学 | 135228篇 |
临床医学 | 435668篇 |
内科学 | 899480篇 |
皮肤病学 | 108398篇 |
神经病学 | 380475篇 |
特种医学 | 178436篇 |
外国民族医学 | 1679篇 |
外科学 | 707121篇 |
综合类 | 102439篇 |
现状与发展 | 15篇 |
一般理论 | 1884篇 |
预防医学 | 374822篇 |
眼科学 | 112999篇 |
药学 | 350500篇 |
17篇 | |
中国医学 | 9185篇 |
肿瘤学 | 246158篇 |
出版年
2018年 | 51020篇 |
2017年 | 38642篇 |
2016年 | 44255篇 |
2015年 | 49767篇 |
2014年 | 69810篇 |
2013年 | 106493篇 |
2012年 | 143417篇 |
2011年 | 152912篇 |
2010年 | 92108篇 |
2009年 | 87083篇 |
2008年 | 143215篇 |
2007年 | 152649篇 |
2006年 | 154550篇 |
2005年 | 149454篇 |
2004年 | 144317篇 |
2003年 | 138949篇 |
2002年 | 134833篇 |
2001年 | 209606篇 |
2000年 | 215716篇 |
1999年 | 183122篇 |
1998年 | 55129篇 |
1997年 | 48228篇 |
1996年 | 48234篇 |
1995年 | 46187篇 |
1994年 | 42740篇 |
1993年 | 40164篇 |
1992年 | 145081篇 |
1991年 | 141590篇 |
1990年 | 138086篇 |
1989年 | 133966篇 |
1988年 | 123596篇 |
1987年 | 121658篇 |
1986年 | 114519篇 |
1985年 | 110221篇 |
1984年 | 82865篇 |
1983年 | 70695篇 |
1982年 | 42025篇 |
1981年 | 38075篇 |
1979年 | 76684篇 |
1978年 | 54473篇 |
1977年 | 46471篇 |
1976年 | 43536篇 |
1975年 | 47029篇 |
1974年 | 56199篇 |
1973年 | 53775篇 |
1972年 | 50740篇 |
1971年 | 47532篇 |
1970年 | 44406篇 |
1969年 | 42145篇 |
1968年 | 38939篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Nursing diagnosis as a critical component of the nursing process provides a common taxonomy to describe problems that nurses can treat and is a convenient, logical way to reference nursing standards. Theory is translated into practice with the use of population-specific prototype care guides and a written orders system. Nurses in leadership are responsible for providing the necessary resources to promote professional growth and facilitate desired change. Recommendations to assist with the implementation of nursing diagnosis are identified in Table 1. The system is dependent on staff nurses' professional commitment to learning and willingness to actively participate in change. Involvement of staff nurses continues to be a critical factor in the improvement of nursing practice. 相似文献
992.
993.
994.
P A DeSimone C A Martin C B Bacdayan J S Macdonald F J Rizzo J Engelberg 《Hospital practice (Office ed.)》1986,21(1):158, 160, 165-158, 7 passim
995.
996.
Alpha-adrenoreceptor reagents. 4. Resolution of some potent selective prejunctional alpha 2-adrenoreceptor antagonists 总被引:1,自引:0,他引:1
A P Welbourn C B Chapleo A C Lane P L Myers A G Roach C F Smith M R Stillings I F Tulloch 《Journal of medicinal chemistry》1986,29(10):2000-2003
The resolution of three 2-substituted derivatives of idazoxan is described. The enantiomers show large separations in activity in a variety of in vitro and in vivo tests, and the active isomers are all potent and selective antagonists at the alpha 2-adrenoreceptor. The significance of these results in relation to those published on the enantiomers of idazoxan and to those on optically active alpha 2-adrenoreceptor agonists is discussed. 相似文献
997.
Synthesis of Estradiol Haptens Two estradiol haptens, 4-(3β,17β-dihydroxyestran-7α-yl)butanoic acid ( 9 ) and 7α-(4-aminobutyl)-3β,17β-estradiols ( 13 ), were prepared from 19-nortestosterone by partial synthesis. The binding activity for the cytosol estrogen receptor was determined by competition against [3H]-estradiol; at a concentration of 2×10?7mol/l, compound 9 displaces 50% of [3H]-estradiol. Attached to AH-Sepharose 4B compound 9 allows the cytosol estrogen receptor from calf uterus to be concentrated 1800-fold by affinity chromatography. 相似文献
998.
999.
Tauseef Ahmed Alan Yagoda Howard I. Scher Cora Sternberg Robin C. Watson 《Investigational new drugs》1986,4(2):171-174
Summary Deaza-aminopterin is a folate analog which is transported more rapidly than methotrexate into cells and appears to be more active than methotrexate against human and animal tumor in vitro. Fifteen patients with advanced urothelial tract cancer were given deaza-aminopterin 30–37.5 mg/m2 IV QW. In responding patients drug was given QOW after 4–6 consecutive doses. Doses were escalated or de-escalated by 7.5 mg/m2 depending on toxicity. Twelve patients had received prior chemotherapy which included methotrexate in nine. Three patients achieved a partial remission lasting 1, 3, and 3 months respectively: all responders had previously failed methotrexate after an initial response to a methotrexate containing regimen. None of the six patients who were methotrexate naive responded to deaza-aminopterin; 3 subsequently received methotrexate without response. Mild mucositis was universal and in 5 was severe. Six patients had an increase in liver transaminases probably secondary to anti-folate hepatotoxicity. Other toxicities included diarrhea, nausea, skin rash and fever. Further studies are needed to define the precise efficacy of deaza-aminopterin in patients with urothelial tract cancers. 相似文献
1000.