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132.
Lulu Huang Lou Massa Isabella Karle Jerome Karle 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(10):3664-3669
Using the Kernel Energy Method we apply ab initio quantum mechanics to study the relative importance of weak and strong interactions (including hydrogen bonds) in the crystal structures of the title compounds TDA1 and RangDP52. Perhaps contrary to widespread belief, in these compounds the weak interaction energies, because of their large number and cooperativity, can be significant to the binding energetics of the crystal, and thus also to its other properties. 相似文献
133.
30 cages of Graves were treated Jn our hospital from 1983 to 1999 and analyzed in clinical symptoms,imnune functicns X- ray and CT scan. Graves disease was believed as an autointnune disease due to high lgA and IgM. Its morbidity was 40 - 75% with increasing orbital fat and hypertrophy of extraocular muscles. Tire specific change was high density of orbital apex in CT scan.The diagnosis could be obtained by its symptoms,T3 inhibiting test and CT.The min treatment in early stage was medication such as horamone, immune inhibitor and dialysis. But surgical treatment should by necessary. 相似文献
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[目的] 系统评价11种中成药治疗小儿厌食症的相对临床疗效。[方法] 计算机检索中国知网、万方数据知识服务平台、维普数据库、中国生物医学文献数据库、PubMed、Web of Science、the Cochrane Library数据库中有关中成药治疗小儿厌食症的随机对照试验,检索时限为数据库建库至2022年5月5日。使用RevMan 5.3、GeMTC 0.14.3、Stata 14.0软件进行结果呈现和数据分析。[结果] 研究共纳入48项随机对照试验,共计7 113名受试者,涉及11种中成药。网状Meta分析结果显示,不同干预措施的临床总有效率排序结果为:肠胃康颗粒>山麦健脾口服液>芪斛楂颗粒>小儿脾胃乐颗粒>儿康宁>沙棘干乳剂>醒脾养儿颗粒>健身消导颗粒>小儿健脾丸>健胃消食口服液>健胃消食片>常规西药。[结论] 中成药治疗小儿厌食症的疗效较为确切,值得临床推广,且肠胃康颗粒、山麦健脾口服液和芪斛楂颗粒概率排序较为靠前,为最佳干预措施的可能性最大,临床上可结合该研究结果及临床实际情况谨慎选择对患者最优的干预措施进行治疗。 相似文献
137.
六应丸中丁香酚的气相色谱测定法 总被引:3,自引:0,他引:3
中成药六应丸是由蟾酥、牛黄、冰片、丁香等药物组成,具有解毒、消炎、退肿、止痛等功效。本文探索了生药公丁香及成药六应丸中的丁香酚的气相色谱测定法,并比较了不同的提取过程对含量测定的影响。方法简便,准确。 相似文献
138.
1 病例介绍 病人,男,70岁.既往无药物过敏史.因前列腺癌术后7年再发排尿困难1年于2007年5月15日收入院. 相似文献
139.
Lulu Yang Chenhui Zhang Wei Wang Junqi Wang Yuan Xiao Wenli Lu Xiaoyu Ma Lifen Chen Jihong Ni Defen Wang Jinxiu Shi Zhiya Dong 《BMC medical genetics》2018,19(1):212
Background
Dwarfism is a common severe growth disorder, but the etiology is unclear in the majority of cases. Recombinant human growth hormone may be a treatment option, but it has limited efficacy. The currently known laboratory assays do not meet the precision requirements for clinical diagnosis. Here, we have constructed a targeted next-generation sequencing (NGS) panel of selected genes that are suspected to be associated with dwarfism for genetic screening.Methods
Genetic screening of 91 children with short stature of unknown etiology was performed with the help of the NGS panel. All the coding regions and exon-intron boundaries of 166 genes were included in the panel. To clarify the pathogenicity of these mutations, their clinical data were reviewed and analyzed.Results
The assay identified p.A72G, p.I282V, and p.P491S variants of the PTPN11 gene and a p.I437T variant of the SOS1 gene in 4 cases with Noonan syndrome. A frameshift mutation (p.D2407fs) of the ACAN gene was identified in a case of idiopathic short stature with moderately advanced bone age. A p.R904C variant of the COL2A1 gene was found in a patient, who was accordingly diagnosed with Stickler syndrome. Severe short stature without limb deformity was associated with a p.G11A variant of HOXD13. In addition, we evaluated evidence that a p.D401N variant of the COMP gene may cause multiple epiphyseal dysplasia.Conclusions
Our findings suggest that syndromes, particularly Noonan syndrome, may be overlooked due to atypical clinical features. This gene panel has been verified to be effective for the rapid screening of genetic etiologies associated with short stature and for guiding precision medicine-based clinical management.140.
1 病例介绍
病人,男,70岁。既往无药物过敏史。因前列腺癌术后7年再发排尿困难1年于2007年5月15日收入院。术前完善各项检查,给予抗肿瘤治疗,第1天静脉输注生理盐水250mL加香菇多糖2mg,25min后,病人颈部、双侧腋下、两侧腰背部、腹部出现大小不等的风团样皮疹,瘙痒严重,无胸闷、心悸、呼吸困难,遵医嘱立即更换液体及输液器,给予地塞米松5mg静脉注射,嘱病人多饮水,勿抓挠,加强心理安慰,30min后瘙痒减轻,1h后皮疹减少,3h后皮疹消失。 相似文献