全文获取类型
收费全文 | 389250篇 |
免费 | 50560篇 |
国内免费 | 16802篇 |
专业分类
耳鼻咽喉 | 7170篇 |
儿科学 | 8351篇 |
妇产科学 | 7250篇 |
基础医学 | 31200篇 |
口腔科学 | 5663篇 |
临床医学 | 56933篇 |
内科学 | 85917篇 |
皮肤病学 | 10093篇 |
神经病学 | 27848篇 |
特种医学 | 14729篇 |
外国民族医学 | 96篇 |
外科学 | 66508篇 |
综合类 | 34522篇 |
现状与发展 | 117篇 |
一般理论 | 45篇 |
预防医学 | 22009篇 |
眼科学 | 9964篇 |
药学 | 25217篇 |
172篇 | |
中国医学 | 10989篇 |
肿瘤学 | 31819篇 |
出版年
2024年 | 1374篇 |
2023年 | 8038篇 |
2022年 | 9937篇 |
2021年 | 14468篇 |
2020年 | 14237篇 |
2019年 | 9664篇 |
2018年 | 15112篇 |
2017年 | 14107篇 |
2016年 | 14781篇 |
2015年 | 18230篇 |
2014年 | 27808篇 |
2013年 | 27084篇 |
2012年 | 22778篇 |
2011年 | 24456篇 |
2010年 | 21766篇 |
2009年 | 23265篇 |
2008年 | 18344篇 |
2007年 | 16662篇 |
2006年 | 18654篇 |
2005年 | 16033篇 |
2004年 | 11500篇 |
2003年 | 9532篇 |
2002年 | 8601篇 |
2001年 | 9735篇 |
2000年 | 9085篇 |
1999年 | 9590篇 |
1998年 | 7258篇 |
1997年 | 7099篇 |
1996年 | 6126篇 |
1995年 | 5765篇 |
1994年 | 4155篇 |
1993年 | 3049篇 |
1992年 | 3656篇 |
1991年 | 3392篇 |
1990年 | 2718篇 |
1989年 | 2618篇 |
1988年 | 2273篇 |
1987年 | 2020篇 |
1986年 | 1824篇 |
1985年 | 1457篇 |
1984年 | 1034篇 |
1983年 | 899篇 |
1982年 | 736篇 |
1981年 | 598篇 |
1980年 | 547篇 |
1979年 | 549篇 |
1978年 | 469篇 |
1977年 | 508篇 |
1975年 | 363篇 |
1972年 | 376篇 |
排序方式: 共有10000条查询结果,搜索用时 8 毫秒
991.
992.
993.
994.
对生长激素缺乏症(GHD)患儿生长激素(GH)治疗前后的免疫功能改变进行了观察。结果显示:(1)GHD患儿NK细胞活性明显降低,经GH治疗3个月后恢复到正常水平;(2)GHD患儿治疗前IL-1a和IL-2活性偏低,治疗后两者有逐渐增高的趋势;(3)治疗前后CD细胞亚群、sIL-2R和LPS诱生的TNFa含量均无明显变化。认为GH缺乏症患儿存在一定的免疫功能缺陷,而GH有调节其免疫功能的作用。 相似文献
995.
Rashmi Kothari MD Kent Hall MD Thomas Brott MD Joseph Broderick MD 《Academic emergency medicine》1997,4(10):986-990
Objective : To develop an abbreviated and practical neurologic scale that could assist emergency medical services or triage personnel in identifying patients with stroke.
Methods : A prospective, observational, cohort study was performed at university-based EDs. Participants were 74 patients treated in a thrombolytic stroke trial and 225 consecutive non-stroke patients evaluated during 4 random 12-hour shifts in the ED. Scores on the NIH Stroke Scale were obtained for all patients by physicians. Items of this scale were modified and recoded to a binomial (normal or abnormal) scale. Serial univariate analyses using χ2 were performed to rank items. Recursive partitioning was then performed to develop the decision rule for predicting the presence of stroke.
Results : Three items identified 100% of patients with stroke: facial palsy, motor arm, and dysarthria. An Abbreviated NIH Stroke Scale based on these items had a sensitivity of 100% and a specificity of 92%. A proposed Out-of-hospital NIH Stroke Scale consisting of facial palsy, motor arm, and a combination of dysarthria and best language items (abnormal speech) had a sensitivity of 100% and a specificity of 88%.
Conclusion : Using the derivation data set, a proposed Out-of-hospital NIH Stroke Scale had a high sensitivity and specificity for identifying patients with stroke when performed by physicians in this group of 299 ED patients. Prospective studies of other health care professionals using the scale in the out-of-hospital arena are needed. 相似文献
Methods : A prospective, observational, cohort study was performed at university-based EDs. Participants were 74 patients treated in a thrombolytic stroke trial and 225 consecutive non-stroke patients evaluated during 4 random 12-hour shifts in the ED. Scores on the NIH Stroke Scale were obtained for all patients by physicians. Items of this scale were modified and recoded to a binomial (normal or abnormal) scale. Serial univariate analyses using χ
Results : Three items identified 100% of patients with stroke: facial palsy, motor arm, and dysarthria. An Abbreviated NIH Stroke Scale based on these items had a sensitivity of 100% and a specificity of 92%. A proposed Out-of-hospital NIH Stroke Scale consisting of facial palsy, motor arm, and a combination of dysarthria and best language items (abnormal speech) had a sensitivity of 100% and a specificity of 88%.
Conclusion : Using the derivation data set, a proposed Out-of-hospital NIH Stroke Scale had a high sensitivity and specificity for identifying patients with stroke when performed by physicians in this group of 299 ED patients. Prospective studies of other health care professionals using the scale in the out-of-hospital arena are needed. 相似文献
996.
Background In patients with vitiligo, sometimes the greatest part of the skin has already lost its melanocytes. The remaining pigmented patches can be removed by using strong bleaching creams, but many adverse events have been reported with this treatment. Anew depigmentation therapy could be treatment with a Ruby laser. Methods Before treatment, the patients filled out a questionnaire about their vitiligo history. Eight patients with remaining pigmentation of the arms, hands, and face were treated once with a Ruby laser. Patients were monitored for developing repigmentation during the 9 months after treatment. Results In patients with a positive Koebner phenomenon, a permanent state of depigmentation was reached after laser therapy. None of the treated patients showed severe side-effects. Conclusions Ruby laser treatment can be an effective, fast, and safe method for removing cosmetically disturbing remnants of normal pigmentation in vitiligo patients with a positive Koebner phenomenon. 相似文献
997.
SUMMARY Impotence is a common symptom which can cause considerable distress to both the sufferer and his partner. The use of pharmacotherapy to improve erectile function will continue to increase as safe and effective drugs are developed. However, restoring erectile function should not be the only treatment objective. It is also essential to address personal and emotional factors in the sufferer, conflicts in his relationship with his partner, and sexual problems in his partner, all of which may be instrumental in causing or maintaining the presenting impotence. We advocate a combined approach with appropriate medical treatment and sex and couple therapy 相似文献
998.
脾脏切除对胸腺和淋巴结免疫功能的影响 总被引:4,自引:0,他引:4
报道脾脏切除(脾切)对动物胸腺和淋巴结免疫功能的影响,脾切后3w大鼠胸腺细胞自发增殖及ConA诱导增殖均无明显变化,ConA诱导淋巴结细胞增殖脾切组明显高于假手术对照组,脾切后3w再用SRBC免疫,5d后小鼠腹腔淋巴结数量脾切明显高于对照组,用QHS法测定淋巴结细胞对SRBC初次抗体产生脾切组则明显低于对照组。 相似文献
999.
五型病毒性肝炎的暴露因素与临床表现的比较 总被引:2,自引:1,他引:1
比较急性病毒性肝炎患者感染打危险因素,同时比较五型肝炎的症状和体征。连续收集急性病毒性肝炎患者血清293份,用ELISA法检测了五型肝炎病毒的病原学指标,并进行了流赞美同学调查。暴露因素:丙肝的肠道外暴露外明显多于甲肝;甲肝和戊肝有较高的“甲肝”患者接触史;乙肝,丙肝和丁肝有高的“乙肝”接触史,与甲肝,戊肝相比差异显著。 相似文献
1000.
Clinical observation of Qi deficiency syndrome in 72 patients with chronic obstructive pulmonary disease treated with Yiqi Mianyi Granule 下载免费PDF全文
Seventy-two patients of chronic obstructive pulmonary disease (COPD) of Qi deficiency syndrome with abnormal immune indices were treated with Yiqi Mianyi Granule (YQMYG) and the efficacy was compared with that of 30 cases treated with Zhenqi fuzheng Granule (ZQFZG) for control. Results showed that the markedly effective rate of symptomatic improvement of Qi deficiency in YQMYG group was 65.3%, the total effective rate 93.1%. 88.6% of the immune indices lower than normal were corrected and 43. 7% of them were normalized, while for indices that were higher than normal the rate were 78.2% and 52.9% respectively. These results suggested that YQMYG could improve symptom of Qi Deficiency markedly, strengthen cellular immunity and regulate immune dysfunction. Its therapeutic efficacy was obviously superior to ZQFZG (P<0.Q5). 相似文献