全文获取类型
收费全文 | 33009篇 |
免费 | 2014篇 |
国内免费 | 165篇 |
专业分类
耳鼻咽喉 | 342篇 |
儿科学 | 788篇 |
妇产科学 | 913篇 |
基础医学 | 4379篇 |
口腔科学 | 1147篇 |
临床医学 | 2527篇 |
内科学 | 8444篇 |
皮肤病学 | 918篇 |
神经病学 | 2666篇 |
特种医学 | 654篇 |
外国民族医学 | 1篇 |
外科学 | 5336篇 |
综合类 | 223篇 |
一般理论 | 8篇 |
预防医学 | 2483篇 |
眼科学 | 584篇 |
药学 | 1790篇 |
中国医学 | 133篇 |
肿瘤学 | 1852篇 |
出版年
2023年 | 250篇 |
2022年 | 498篇 |
2021年 | 1120篇 |
2020年 | 525篇 |
2019年 | 1062篇 |
2018年 | 1233篇 |
2017年 | 716篇 |
2016年 | 732篇 |
2015年 | 940篇 |
2014年 | 1312篇 |
2013年 | 1637篇 |
2012年 | 2549篇 |
2011年 | 2612篇 |
2010年 | 1551篇 |
2009年 | 1367篇 |
2008年 | 2125篇 |
2007年 | 2202篇 |
2006年 | 2006篇 |
2005年 | 1793篇 |
2004年 | 1642篇 |
2003年 | 1566篇 |
2002年 | 1432篇 |
2001年 | 371篇 |
2000年 | 355篇 |
1999年 | 367篇 |
1998年 | 249篇 |
1997年 | 213篇 |
1996年 | 203篇 |
1995年 | 170篇 |
1994年 | 140篇 |
1993年 | 113篇 |
1992年 | 195篇 |
1991年 | 167篇 |
1990年 | 156篇 |
1989年 | 138篇 |
1988年 | 163篇 |
1987年 | 121篇 |
1986年 | 116篇 |
1985年 | 103篇 |
1984年 | 92篇 |
1983年 | 80篇 |
1982年 | 76篇 |
1981年 | 74篇 |
1980年 | 69篇 |
1979年 | 55篇 |
1978年 | 48篇 |
1977年 | 53篇 |
1976年 | 50篇 |
1974年 | 61篇 |
1973年 | 44篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
Stroke-induced hemiballismus (HB) has been reported to improve motor function in people with Parkinson's disease (PD). We report on a patient who developed HB from a parietal infarct. The HB was improved by very low-dose clozapine but the HB did not improve the parkinsonism. This suggests that HB itself, whether from a lesion in the subthalamic nucleus or elsewhere, is not what improves motor function in PD; instead, the physiological function of the damaged structure is the determining factor. 相似文献
62.
63.
Antonio Vidaller Fernando Guadarrama Luis Llorente Juan Pablo Méndez Fernando Larrea Antonio R. Villa Donato Alarcón-Segovia 《Journal of clinical immunology》1992,12(3):210-215
We studied NK cell function in eight patients with pathological hyperprolactinemia by measuring51Cr release by K562 cells exposed to their mononuclear cells and found it decreased compared to normal controls (P<0.01). Bromocriptine (BrC) treatment corrected NK function but also made it more efficient at 12:1 than at 25:1 or 50:1 effector:target ratios (ANOVA;P=0.01). The study of NK cell function in agarose revealed that its decrease in hyperprolactinemia is due to their low active binding to target cells, active killing, and recycling capacity. BrC tended to correct them but also increased recycling capacity to levels higher than those of controls (P<0.05). Sequential studies in three hyperprolactinemic patients before and after BrC showed correction of NK function within 1 week but its increased efficiency at the 12:1 effector:target ratio required 8 weeks. We conclude that hyperprolactinemia decreases NK cell function. BrC corrects this by decreasing prolactin levels but also makes NK function more efficient by increasing the capacity of NK cells to recycle after killing. 相似文献
64.
A Aguirre Vila-Coro S Bonafonte J N Fernandez del Cotero 《Annals of ophthalmology》1988,20(10):367-370
Two patients underwent bilateral radial keratotomy procedures and developed epithelial inclusion cysts as a postoperative complication. Metal blades were used for the corneal incisions; this might be related to the development of the cysts. 相似文献
65.
C Albet J M Fernandez E Rozman J A Perez A Sacristan J A Ortiz 《Journal of pharmaceutical and biomedical analysis》1992,10(2-3):205-211
A high-performance liquid chromatographic method is developed for the determination of bulk sertaconazole nitrate and related compounds (potential impurities and degradation products) as well as a sertaconazole nitrate cream formulation. A 10-microns Spherisorb CN column is used along with a mobile phase consisting of acetonitrile and aqueous 0.01 M sodium phosphate (37:63, v/v). The sertaconazole nitrate peak is monitored at a wavelength of 260 nm; the retention time being 19.3 min. The detector response for sertaconazole nitrate is linear over the concentration range from 64 to 96 micrograms ml-1. The method is found to be sufficiently selective for the reliable determination of related compounds, FI-7001, FI-7009 and FI-7011, as indicated by same-day and between-day relative standard deviations (RSD) for replicate assays of 1.72% (n = 9) and 2.17% (n = 24), respectively. The application of this method to a cream formulation of sertaconazole nitrate is found to give a mean percentage recovery of 99.4% with RSD of 1.14% (n = 9); none of the cream vehicle peaks are found to interfere with the determination of sertaconazole nitrate. 相似文献
66.
Yutaka Yonemura Masataka Segawa Hisashi Matsumoto Kouichirou Tsugawa Itasu Ninomiya Luis Fonseca Takashi Fujimura Kazuo Sugiyama Kouichi Miwa Itsuo Miyazaki 《Surgery today》1994,24(6):488-493
Because gastric cancers located in the upper third of the stomach are difficult to detect at an early stage, the surgical results remain poor. We performed R4 gastrectomy as a radical procedure for 25 patients, involving complete resection of the latero-aortic and interaorticovenous lymph modes above and below the left renal vein, in combination with the ordinary R2 or R3 gastrectomy (the R4 group). These patients were compared with 156 others who underwent R2 gastrectomy alone (the R2 group). There were no significant differences in operation time, blood loss, or the incidence of complications between the two groups; however, when the survival rates of the patients with tumors invading beyond the subserosa were compared, the 5-year survival rate was found to be significantly higher in the R4 group than in the R2 group. Furthermore, in patients with para-aortic nodal involvement, a significant survival advantage was observed in the R4 group, as compared with the R2 group. These results suggest that the R4 gastrectomy is a rational approach for patients with advanced gastric cancer located in the upper third of the stomach. 相似文献
67.
Felipe A. Calvo David Ortiz de Urbina Luis Sierrasesúmaga Oscar Abuchaibe Ignacio Azinovic Federico Antillon Manuel Santos Jos Canadell 《Pediatric blood & cancer》1991,19(6):478-485
From September 1984 to December 1989, 38 patients of pediatric age with localized bone sarcomas received intraoperative radiotherapy (IORT) as part of a multidisci plinary treatment program. The age ranged from 6 to 21 years. The tumor histologies were 22 osteosarcomas and 16 Ewing's sarcomas. Thirty-four had initial primary disease (90%) and 4 were treated for local recurrence (10%). IORT was used on 32 untreated patients and in 6 previously treated with external beam radiotherapy (EBR). The IORT field included the surgically exposed tumor bed area. Single radiation doses ranging from 10 to 20 Gy were delivered, using 6–20 MeV electron beams. The median follow-up time for the entire group is 25 months (2–65+ months). The projected 5-year disease-free and overall survival rates are 65% and 69%, respectively. One patient developed a local recurrence in each histological group: one chondroblastic osteosarcoma and one cervical Ewing's sarcoma. Six patients died from metastatic progression: 3 initially recurrent tumors and three primary disease cases. Severe neuropathy and soft tissue necrosis were seen in some patients as IORT related complications. IORT is a feasible technique to be integrated in multidisciplinary programs that may promote local control in pediatric and adolescent patients with bone sarcomas. Peripheral nerves are dose-limiting tissue structures for IORT. 相似文献
68.
J. P. Dedet R. Melogno F. Cardenas L. Valda C. David V. Fernandez M. E. Torrez L. Dimier-David P. Lyevre M. E. Villareal 《Bulletin of the World Health Organization》1995,73(3):339-345
Mucocutaneous leishmaniasis (MCL) is endemic in the tropical Amazonian lowlands of Bolivia, an area that regularly receives influxes of migratory populations. In these new agricultural development areas, a campaign to diagnose and treat the disease was carried out between 1989 and 1992, in order to provide direct access to MCL treatment in the endemic areas at a standard equivalent to that offered in the urban centres in Bolivia. The campaign led to the creation of decentralized local centres for diagnosis and treatment of the disease. A campaign to inform the population about leishmaniasis was also undertaken and courses were run to educate medical and paramedical personnel. As a result of the campaign, 3285 cases of leishmaniasis were diagnosed, including 2152 cutaneous and 326 mucosal forms. Also, a total of 1888 cases were treated, 1677 of which cutaneous and 211, mucosal. 相似文献
69.
L Fuller J Fernandez S Zheng M Carreno V Esquenazi W C Yang J Miller 《Transplantation》1992,53(1):195-202
We have advanced the hypothesis that the primary autolymphoproliferative response of dog T cells in mixed lymphocyte kidney cultures (MLKC) results from their recognition of tissue-specific (kidney-associated) antigen(s) presented in conjunction with class II MHC antigens. Lymphocyte culture-derived supernatants had been found previously to upregulate class II antigen expression on kidney cells and enhance T cell activation. In the present study we have isolated and characterized dog IFN-gamma, a class II-inducing substance that is secreted in the culture supernatant of activated T lymphocytes. Dog IFN-gamma was induced with A-23187 and PMA and purified stepwise using controlled-pore glass, Mono Q anion exchange chromatography, and Superose 6-gel filtration on FPLC. The purification resulted in two molecules of 42 Kd and 31 Kd molecular weights. An IgG1 monoclonal antibody was engendered to these molecules. With this mAb reagent, in immunochemical experiments, we have developed a sensitive ELISA and a method for purifying dog IFN-gamma by affinity chromatography. Species specificity studies indicated that purified dog IFN-gamma reacted with a polyclonal rabbit antihuman IFN-gamma, but not with a mAb to human IFN-gamma. However, the antidog IFN-gamma mAb that was generated also reacted with recombinant human IFN-gamma. In in vitro biological studies, the purified IFN-gamma (two mol. wt. species) upregulated the expression of canine class II MHC molecules on dog tubular epithelial cells and the dog kidney epithelial cell line (MDCK). The antidog IFN-gamma mAb blocked T cell proliferative response to kidney cell and, by inference, the interaction between endogenously released IFN-gamma in vitro with its cell surface receptor, thus inhibiting the induced upregulation of class II. Interestingly, although antidog IFN-gamma markedly blocked the MLKC (10 micrograms mAb/well), there was no effect on the allogeneic MLC. This observation indicates that the cytokine IFN-gamma may be a uniquely key substance amplifying the immune response of T cells to tissue-associated antigens on surrogate antigen-presenting cells that require induced upregulation of class II MHC antigen expression (MLKC), in contrast to reactions in which these antigens are already constitutively expressed on the antigen-presenting cells (mixed lymphocyte culture). 相似文献
70.
Kimberly M Miller Michael S Okun Hubert F Fernandez Charles E Jacobson Ramon L Rodriguez Dawn Bowers 《Movement disorders》2007,22(5):666-672
Depression is common in Parkinson's disease (PD) and affects 30 to 50% of all patients. In contrast to the wealth of research on depression in PD, little is known about the occurrence of depression in other movement disorders. The primary objective of the current study was to determine whether the high prevalence of depression symptoms seen in PD is also found in other movement disorders, by directly comparing rates of specific depression symptoms and depression severity across PD, dystonia, and essential tremor (ET). Three hundred and fifty-four patients with PD, 83 patients with dystonia, and 53 patients with ET completed the Beck Depression Inventory (BDI). We found no significant between-groups differences for depression severity, frequency, or endorsement of specific depression symptoms. Forty-eight percent of PD patients, 37.3% of dystonia patients, and 34% of ET patients were found to be at least mildly depressed (BDI score of 10 or higher). The most commonly endorsed symptoms were fatigability, difficulty with work, anhedonia, and sleep disturbance. Clinicians should be aware that depression is a frequent problem in dystonia and ET, in addition to PD, and inquire about depression symptoms in these patients so that they can be appropriately treated. 相似文献