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991.
Luigi Benini Tiziana Todesco Luca Frulloni Riccardo Dalle Grave Pietro Campagnola Flora Agugiaro Caterina Daniela Cusumano Armando Gabbrielli Italo Vantini 《Digestive and liver disease》2010,42(11):767-772
Background
Esophageal symptoms are common in anorexia nervosa, but it is not known whether they are associated with motility disorders, with different forms of the disease, and whether they respond to nutritional rehabilitation.Methods
To clarify these points, 23 patients with anorexia nervosa (12 binge-eating/purging, “purgers”; 11 restricting type, “restricters”) were studied by esophageal manometry before and after 22 weeks rehabilitation. Manometric parameters of 35 age and sex-matched patients were used as controls. Patients with anorexia also filled questionnaires on eating disorder psychopathology, psychopathological distress and esophageal, gastric and colonic symptoms before and after 4 and 22 weeks of a rehabilitation program.Results
Symptoms were more severe in patients than in controls. Gastric and colonic, but not esophageal symptoms improved with treatment. LES basal pressure was higher in restricters (restricters 32.1 ± 4.6; purgers 14.9 ± 2.2; controls 17.1 ± 1.1 mm Hg, p < 0.005), but still within normal range; this difference disappeared after treatment. Postdeglutitive body waves were normally propagated. Their amplitude was significantly higher in anorexia than in controls. No correlation was found between results of psychopathological tests (improved after treatment), esophageal symptoms and manometry.Conclusions
In anorexia, esophageal symptoms are frequent and severe. They are not adequately explained by psychological or manometric derangements. 相似文献992.
Pier Luigi Temporelli Francesco Scapellato Ugo Corrà Massimo Pistono Ermanno Eleuteri Alessandro Imparato Pantaleo Giannuzzi 《European journal of cardiovascular prevention and rehabilitation》2008,15(4):441-447
BACKGROUND: Scant data exist on factors that may identify outcome in patients with severe left ventricular (LV) dysfunction early after coronary artery bypass graft surgery (CABG). DESIGN: This study was designed to determine the prognostic value of clinical, operative, and postoperative factors in patients with LV dysfunction early after CABG. METHODS: In 333 consecutive patients with ejection fraction < or =35% on admission to residential cardiac rehabilitation after isolated CABG, potential preoperative, perioperative, and postoperative predictors of outcome, including 6-month LV remodeling, were recorded and patients followed up for a median of 3 years. The study end points were cardiovascular (CV) mortality and the combination of CV mortality and nonfatal CV events requiring hospitalization. RESULTS: The 3-year CV mortality-free survival and survival free of nonfatal CV event rates were 87 and 73%, respectively. Independent predictors of CV mortality were history of congestive heart failure [hazard ratio, HR: 2.8; 95% Confidence Interval (CI): 1.51-5.21], low ejection fraction on admission to cardiac rehabilitation (HR: 0.9; 95% CI: 0.87-0.96), and early complications after CABG (HR: 2.5; 95% CI: 1.23-5.15). When the combined end points were considered, postoperative left atrial size (HR: 1.07; 95% CI: 1.01-1.11), New York Heart Association class III or IV (HR: 1.69; 95% CI: 1.04-2.74), and 6-month remodeling (HR: 2.12; 95% CI: 1.33-3.36) were independent predictors. CONCLUSION: Simple preoperative and postoperative variables may help identify patients with LV dysfunction early after CABG who are still at risk of major CV events. In this setting, 6-month LV remodeling is a strong predictor of a poor prognosis. 相似文献
993.
Vittorio Stefoni Alessandro Broccoli Cinzia Pellegrini Enrico Derenzini Mariapaola Fina Pier Luigi Zinzani 《Journal of neuro-oncology》2009,95(1):135-139
Objective Estradiol (E2) acts to modulate the ratio of two dopamine D2 receptor isoforms (D2L/D2S) by the nuclear estrogen receptor
(ER) and to reduce dopamine’s inhibitory action on PRL secretion. Here we demonstrate the correlation between the expression
of ER mRNA and D2R mRNA isoforms in pituitary neoplasms cells. Methods Twenty-four human pituitary adenomas (14 prolactinomas and 10 gonadotrope tumors) were examined for the expression of both
ER mRNA and D2R mRNA by means of semi-quantitative RT-PCR analysis. Results No significant difference was found in ERβ mRNA expression levels between prolactinomas and gonadotrope tumors (P = 0.871), but there was a significant difference in the expression of ERα mRNA (P = 0.003). The significant difference was found between the two pituitary adenomas types in both levels of D2S and D2L mRNA
expression (P = 0.036 and 0.007 respectively). Furthermore, both levels of expression in prolactinomas were significantly higher than that
in gonadotrope tumors. Additionally, a negative correlation between D2S and ERα mRNA expression and a positive correlation
between D2L and ERα mRNA expression were found in these tumors. Conclusion This study for the first time shows a good correlation between expression of ER and D2R isoforms in prolactinomas and gonadotrope
tumors. Reducing the amount of the ERα in neoplasm cells can alter the ratio of D2L/D2S, which may increase the drug sensitivity
of pituitary adenomas. 相似文献
994.
Pan D Schomber T Kalberer CP Terracciano LM Hafen K Krenger W Hao-Shen H Deng C Skoda RC 《Blood》2007,110(8):3049-3055
The tumor suppressor Smad4 mediates signaling by the transforming growth factor beta (TGF-beta) superfamily of ligands. Previous studies showed that several TGF-beta family members exert important functions in hematopoiesis. Here, we studied the role of Smad4 in adult murine hematopoiesis using the inducible Mx-Cre/loxP system. Mice with homozygous Smad4 deletion (Smad4(Delta/Delta)) developed severe anemia 6 to 8 weeks after induction (mean hemoglobin level 70 g/L). The anemia was not transplantable, as wild-type mice reconstituted with Smad4(Delta/Delta) bone marrow cells had normal peripheral blood counts. These mice did not develop an inflammatory disease typical for mice deficient in TGF-beta receptors I and II, suggesting that the suppression of inflammation by TGF-beta is Smad4 independent. The same results were obtained when Smad4 alleles were deleted selectively in hematopoietic cells using the VavCre transgenic mice. In contrast, lethally irradiated Smad4(Delta/Delta) mice that received wild-type bone marrow cells developed anemia similar to Smad4(Delta/Delta) mice that did not receive a transplant. Liver iron stores were decreased and blood was present in stool, indicating that the anemia was due to blood loss. Multiple polyps in stomach and colon represent a likely source of the bleeding. We conclude that Smad4 is not required for adult erythropoiesis and that anemia is solely the consequence of blood loss. 相似文献
995.
996.
Alberto Martino Marco Di Serafino Lucio Amitrano Luigi Orsini Lorena Pietrini Rossana Martino Antonella Menchise Luca Pignata Luigia Romano Giovanni Lombardi 《World journal of gastrointestinal endoscopy》2022,14(12):739-747
Non-variceal upper gastrointestinal bleeding (NVUGIB) is a common gastroenterological emergency associated with significant morbidity and mortality. Upper gastrointestinal endoscopy is currently recommended as the gold standard modality for both diagnosis and treatment, with computed tomography traditionally playing a limited role in the diagnosis of acute NVUGIB. Following the introduction of multidetector computed tomography (MDCT), this modality is emerging as a promising tool in the diagnosis of NVUGIB. However, to date, evidence concerning the role of MDCT in the NVUGIB diagnosis is still lacking. The aim of our study was to review the current evidence concerning the role of MDCT in the diagnosis of acute NVUGIB. 相似文献
997.
Scoping review shows wide variation in the definitions of bronchopulmonary dysplasia in preterm infants and calls for a consensus 下载免费PDF全文
Delaney Hines Neena Modi Shoo K. Lee Tetsuya Isayama Gunnar Sj?rs Luigi Gagliardi Liisa Lehtonen Maximo Vento Satoshi Kusuda Dirk Bassler Rintaro Mori Brian Reichman Stellan H?kansson Brian A. Darlow Mark Adams Franca Rusconi Laura San Feliciano Kei Lui Naho Morisaki Natasha Musrap Prakesh S. Shah the International Network for Evaluating Outcomes of Neonates 《Acta paediatrica (Oslo, Norway : 1992)》2017,106(3):366-374
998.
Alessandro De Cesare Barbara Cangemi Enrico Fiori Marco Bononi Roberto Cangemi Luigi Basso 《Surgery today》2014,44(8):1424-1433
Purpose
To evaluate the early and long-term postoperative results of malabsorptive surgery in morbidly obese patients.Methods
Between 2000 and 2007, 102 morbidly obese patients were referred to the Department of Surgery “Pietro Valdoni”, “Sapienza” University of Rome, Policlinico “Umberto I°”, Rome, Italy for malabsorptive surgery. All patients underwent derivative biliodigestive surgery after they had been reviewed by a team of surgeons, physicians, dieticians, and psychologists.Results
There were no intra-operative complications, but two patients suffered postoperative pulmonary embolisms, which resolved with medical treatment. The mean postoperative hospital stay was 7 days, with no early or late mortality. Maximum weight loss was reached 12–24 months after surgery, while the mean percentage excess weight loss at 3–5 years ranged from 45 to 64 %. Specific postoperative complications in the first 2 years after surgery were abdominal abscess (n = 2), gastroduodenal reflux (n = 4), and incisional hernia (n = 6). Diabetes resolved in 98 % of the diabetic patients within a few weeks after surgery and blood pressure normalised in 86.4 % of those who had had hypertension preoperatively. Obstructive sleep apnoea and obesity hypoventilation syndrome also improved significantly in 92 % of the patients.Conclusions
Morbidly obese patients can undergo biliodigestive surgery safely with good long-term weight loss and quality of life expectancy. 相似文献999.
Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis 总被引:29,自引:0,他引:29
Muratori P Muratori L Ferrari R Cassani F Bianchi G Lenzi M Rodrigo L Linares A Fuentes D Bianchi FB 《The American journal of gastroenterology》2003,98(2):431-437
OBJECTIVES: The clinical impact of antinuclear antibodies in primary biliary cirrhosis is uncertain. We analyzed in detail the antinuclear antibodies reactivity of primary biliary cirrhosis patients and correlated the fine specificities observed with clinical, biochemical, and immunologic parameters. METHODS: A total of 96 consecutive primary biliary cirrhosis patients and 283 pathologic controls were studied. To dissect the fine antinuclear antibodies specificities we used different techniques, such as indirect immunofluorescence on cryostat tissue sections and cell culture (HEp-2 cells), counterimmunoelectrophoresis with thymus and spleen extracts, ELISA assays with recombinant Sp100 and purified gp210 and Lamin B receptor, and immunoblot with several recombinant nuclear and cytoplasmic antigens. RESULTS: Antinuclear antibodies were detected in 53% of patients, with the following hierarchy of specificities: 27% anti-Sp100, 16% "multiple nuclear dots," 16% anti-gp210, 16% anti-centromere, 7% XR1, 6% anti-lamin B receptor, 5% anti-SS-A/Ro, 5% anti-ribonucleoprotein, 4% XR2, 2% anti-SS-B/La, 2% perinuclear antineutrophil cytoplasmic antibodies, and 1% anti-double-stranded deoxyribonucleic acid. Several patients showed multiple specificities. The "multiple nuclear dots" pattern was detected more often in antimitochondrial antibodies negative patients. In particular, primary biliary cirrhosis specific antinuclear antibodies (anti-Sp100, anti-gp210, and anti-lamin B receptor) were detected in nine of 13 antimitochondrial negative primary biliary cirrhosis cases. Anti-gp210 was more frequent in patients with more pronounced cholestasis and more impaired liver function. CONCLUSIONS: Antinuclear antibodies reactivities are present in more than half of primary biliary cirrhosis patients and target diverse autoantigens located in distinct subnuclear structures. Anti-gp210 identifies a subgroup of primary biliary cirrhosis patients with more serious liver disease. Positivity for anti-Sp100, anti-gp210, and anti-lamin B receptor, either alone or in combination, may act as a serologic marker of antimitochondrial antibodies negative primary biliary cirrhosis. 相似文献
1000.
De Riu PL Russo A Pellitteri R Stanzani S Tringali G Roccazzello AM De Riu G Marongiu P Mameli O 《Experimental neurology》2008,213(1):101-107
Alpha-tyrosinated tubulin is a cytoskeletal protein that is involved in axonal growth and is considered a marker of neuronal plasticity in adult mammals. In adult rats, unilateral ablation of the left facial sensorimotor cortical areas induces degeneration of corticotrigeminal projections and marked denervation of the contralateral sensory trigeminal nuclei. Western blotting and real-time-PCR of homogenates of the contralateral trigeminal ganglion (TG) revealed consistent overexpression of growth proteins 15 days after left decortication in comparison with the ipsilateral side. Immunohistochemical analyses indicated marked overexpression of α-tyrosinated tubulin in the cells of the ganglion on the right side. Cytoskeletal changes were primarily observed in the small ganglionic neurons. Application of HRP-CT, WGA-HRP, and HRP to infraorbital nerves on both sides 15 days after left decortication showed a significant degree of terminal sprouting and neosynaptogenesis from right primary afferents at the level of the right caudalis and interpolaris trigeminal subnuclei. These observations suggest that the adaptive response of TG neurons to central deafferentation, leading to overcrowding and rearrangement of the trigeminal primary afferent terminals on V spinal subnuclei neurons, could represent the anatomical basis for distortion of facial modalities, perceived as allodynia and hyperalgesia, despite nerve integrity. 相似文献