排序方式: 共有16条查询结果,搜索用时 6 毫秒
11.
Epidemiology of asthma 总被引:2,自引:0,他引:2
The epidemiology of asthma is complex but essential in enhancing the understanding of a disease that affects millions of patients. Asthma is associated with significant morbidity and mortality. Asthma prevalence rates in the United States reached a plateau after 1998 with an estimated overall prevalence of 3.8% in 2003. Racial disparities exist and there are staggering differences in morbidity and mortality. The analysis of data collected from epidemiologic studies continues to be a critical part of enhancing the understanding of the pathophysiology of asthma, which will lead to improved patient outcomes. 相似文献
12.
Juan Carlos Cardet Margee Louisias Tonya S. King Mario Castro Christopher D. Codispoti Ryan Dunn Linda Engle B. Louise Giles Fernando Holguin John J. Lima Dayna Long Njira Lugogo Sharmilee Nyenhuis Victor E. Ortega Sima Ramratnam Michael E. Wechsler Elliot Israel Wanda Phipatanakul 《The Journal of allergy and clinical immunology》2018,141(2):754-760.e3
13.
14.
Asthma is characterized by reversible bronchial hyper-responsiveness and airway inflammation, and encompasses a wide variety of patients with different clinical phenotypes that display variable responses to therapy. The definition of genomic variation presented in the Human Genome Project has facilitated the development of genetic-guided therapy in various diseases, including asthma. Tailored therapy is a reality in many types of malignancies where specific gene mutations or molecular profiles are identified and used to make critical therapeutic decisions. Despite the identification of beta-adrenergic receptor polymorphisms by Liggett and colleagues during the 1990s, the pharmacogenetics of asthma is still in its infancy. There have been great advances in asthma pharmacogenetics and pharmacotherapy with the completion of several large trials highlighting the effects of genotype on response to asthma therapy. This review focuses on research articles that serve to emphasize the potential role of using genotyping as a tool to develop individualized patient treatment regimens for asthma, thus improving outcomes and limiting adverse effects of certain therapies. 相似文献
15.
Njira Lugogo Cynthia L. Green Noah Agada Siyi Zhang Susanne Meghdadpour Run Zhou Siyun Yang Kevin J. Anstrom Elliot Israel Richard Martin Robert F. Lemanske Homer Boushey Stephen C. Lazarus Stephen I. Wasserman Mario Castro William Calhoun Stephen P. Peters Emily DiMango Monica Kraft 《The Journal of allergy and clinical immunology》2018,141(3):1096-1104
16.
Asthma prevalence and mortality have been increasing over the past 2 decades, despite advances in medical therapy. In 2003 the National Health Interview Survey reported over 4,000 asthma-related deaths. A small proportion of people with severe asthma use a large proportion of health-care resources and bear the burden of asthma-related morbidity and mortality. The management of acute asthma is complex and evolving. Understanding the phenotypes and pathophysiology of acute asthma will lead to increased recognition and characterization of populations at risk for fatal asthma. The early identification and appropriate management of acute asthma is critical in decreasing asthma morbidity and mortality. This paper reviews current pharmacologic and nonpharmacologic management of severe acute asthma. 相似文献