全文获取类型
收费全文 | 9089篇 |
免费 | 602篇 |
国内免费 | 75篇 |
专业分类
耳鼻咽喉 | 48篇 |
儿科学 | 237篇 |
妇产科学 | 262篇 |
基础医学 | 1441篇 |
口腔科学 | 222篇 |
临床医学 | 767篇 |
内科学 | 2119篇 |
皮肤病学 | 213篇 |
神经病学 | 980篇 |
特种医学 | 315篇 |
外科学 | 808篇 |
综合类 | 41篇 |
一般理论 | 5篇 |
预防医学 | 730篇 |
眼科学 | 191篇 |
药学 | 599篇 |
中国医学 | 53篇 |
肿瘤学 | 735篇 |
出版年
2024年 | 4篇 |
2023年 | 93篇 |
2022年 | 191篇 |
2021年 | 340篇 |
2020年 | 226篇 |
2019年 | 269篇 |
2018年 | 313篇 |
2017年 | 236篇 |
2016年 | 278篇 |
2015年 | 321篇 |
2014年 | 405篇 |
2013年 | 470篇 |
2012年 | 772篇 |
2011年 | 783篇 |
2010年 | 401篇 |
2009年 | 394篇 |
2008年 | 562篇 |
2007年 | 619篇 |
2006年 | 557篇 |
2005年 | 564篇 |
2004年 | 486篇 |
2003年 | 398篇 |
2002年 | 356篇 |
2001年 | 48篇 |
2000年 | 48篇 |
1999年 | 63篇 |
1998年 | 80篇 |
1997年 | 66篇 |
1996年 | 52篇 |
1995年 | 57篇 |
1994年 | 31篇 |
1993年 | 49篇 |
1992年 | 20篇 |
1991年 | 21篇 |
1990年 | 23篇 |
1989年 | 12篇 |
1988年 | 17篇 |
1987年 | 15篇 |
1986年 | 13篇 |
1985年 | 13篇 |
1984年 | 9篇 |
1983年 | 10篇 |
1982年 | 10篇 |
1981年 | 9篇 |
1980年 | 7篇 |
1979年 | 11篇 |
1976年 | 5篇 |
1974年 | 6篇 |
1969年 | 4篇 |
1946年 | 3篇 |
排序方式: 共有9766条查询结果,搜索用时 187 毫秒
971.
OBJECTIVE: To translate the Family Environment Scale into Portuguese and apply the instrument to validate it. METHODS: The translation was applied to members of Brazilian families with the aim of evaluating its internal consistency and the concordance between members of the same family. One hundred and fifty-four volunteers living in the city of S?o Paulo in 2003 who were not receiving any kind of intervention for dealing with family problems were selected. The mean scores in the ten subscales of the instrument were compared between men and women, and between members of the same family. The internal consistency was evaluated by means of Cronbach's alpha. RESULTS: The maximum possible score in each subscale was nine (good family functioning), except in relation to conflict and control. In most of the subscales, the mean score of the sample studied ranged from 5.1 to 7.6 (men) and 5.4 to 7.7 (women). In the conflict and control subscales, the means ranged from 1.8 to 4.6 (men) and 1.6 to 4.6 (women). These were similar to scores reported in international studies, except for higher scores in the cohesion and organization subscales, and lower score in the conflict subscale. There were no statistically significant differences between the scores attained by men and women. The reliability of the scale, evaluated according to Cronbach's alpha, ranged from 0.61 to 0.78 for the ten subscales. CONCLUSIONS: Cultural factors may have influenced the results obtained in some of the subscales. The Portuguese version of the Family Environment Scale presented reasonable internal consistency that enables its use for evaluating changes in the family's environment and its functioning and after therapeutic interventions. 相似文献
972.
973.
Guillermo Montalban-Bravo MD Rashmi Kanagal-Shamanna MD Koji Sasaki MD PhD Lucia Masarova MD Kiran Naqvi MD Elias Jabbour MD Courtney D. DiNardo MD Koichi Takahashi MD PhD Marina Konopleva MD PhD Naveen Pemmaraju MD Tapan M. Kadia MD Farhad Ravandi MD Naval Daver MD Gautam Borthakur MBBS Zeev Estrov MD Joseph D. Khoury MD Sanam Loghavi MD Kelly A. Soltysiak PhD Sherry Pierce RN Carlos Bueso-Ramos MD PhD Keyur P. Patel MD PhD Srdan Verstovsek MD Hagop M. Kantarjian MD Prithviraj Bose MD Guillermo Garcia-Manero MD 《Cancer》2021,127(17):3113-3124
974.
Tobias Paul Seraphin MD Walburga Yvonne Joko-Fru MD Lucia Hämmerl MD Mirko Griesel MD Nikolaus Christian Simon Mezger MD Jana Cathrin Feuchtner MD Innocent Adoubi MD Marcel Dieu-Donné Egué BSc Nathan Okerosi Henry Wabinga MD Rolf Hansen BBA Samukeliso Vuma MD Cesaltina Lorenzoni PhD Bourama Coulibaly MD Sévérin W. Odzebe MD Nathan Gyabi Buziba MD Abreha Aynalem MD Biying Liu MPH Daniel Medenwald MD Rafael T. Mikolajczyk MD Jason Alexander Efstathiou MD Donald Maxwell Parkin MD Ahmedin Jemal PhD Eva Johanna Kantelhardt MD 《Cancer》2021,127(22):4221-4232
975.
Mirko Griesel Tobias P. Seraphin Nikolaus C.S. Mezger Lucia Hämmerl Jana Feuchtner Walburga Yvonne Joko-Fru Mazvita Sengayi-Muchengeti Biying Liu Samukeliso Vuma Anne Korir Gladys C. Chesumbai Sarah Nambooze Cesaltina F. Lorenzoni Marie-Thérèse Akele-Akpo Amalado Ayemou Cheick B. Traoré Tigeneh Wondemagegnehu Andreas Wienke Christoph Thomssen Donald M. Parkin Ahmedin Jemal Eva J. Kantelhardt 《The oncologist》2021,26(5):e807-e816
BackgroundCervical cancer (CC) is the most common female cancer in many countries of sub‐Saharan Africa (SSA). We assessed treatment guideline adherence and its association with overall survival (OS).MethodsOur observational study covered nine population‐based cancer registries in eight countries: Benin, Ethiopia, Ivory Coast, Kenya, Mali, Mozambique, Uganda, and Zimbabwe. Random samples of 44–125 patients diagnosed from 2010 to 2016 were selected in each. Cancer‐directed therapy (CDT) was evaluated for degree of adherence to National Comprehensive Cancer Network (U.S.) Guidelines.ResultsOf 632 patients, 15.8% received CDT with curative potential: 5.2% guideline‐adherent, 2.4% with minor deviations, and 8.2% with major deviations. CDT was not documented or was without curative potential in 22%; 15.7% were diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IV disease. Adherence was not assessed in 46.9% (no stage or follow‐up documented, 11.9%, or records not traced, 35.1%). The largest share of guideline‐adherent CDT was observed in Nairobi (49%) and the smallest in Maputo (4%). In patients with FIGO stage I–III disease (n = 190), minor and major guideline deviations were associated with impaired OS (hazard rate ratio [HRR], 1.73; 95% confidence interval [CI], 0.36–8.37; HRR, 1.97; CI, 0.59–6.56, respectively). CDT without curative potential (HRR, 3.88; CI, 1.19–12.71) and no CDT (HRR, 9.43; CI, 3.03–29.33) showed substantially worse survival.ConclusionWe found that only one in six patients with cervical cancer in SSA received CDT with curative potential. At least one‐fifth and possibly up to two‐thirds of women never accessed CDT, despite curable disease, resulting in impaired OS. Investments into more radiotherapy, chemotherapy, and surgical training could change the fatal outcomes of many patients.Implications for PracticeDespite evidence‐based interventions including guideline‐adherent treatment for cervical cancer (CC), there is huge disparity in survival across the globe. This comprehensive multinational population‐based registry study aimed to assess the status quo of presentation, treatment guideline adherence, and survival in eight countries. Patients across sub‐Saharan Africa present in late stages, and treatment guideline adherence is remarkably low. Both factors were associated with unfavorable survival. This report warns about the inability of most women with cervical cancer in sub‐Saharan Africa to access timely and high‐quality diagnostic and treatment services, serving as guidance to institutions and policy makers. With regard to clinical practice, there might be cancer‐directed treatment options that, although not fully guideline adherent, have relevant survival benefit. Others should perhaps not be chosen even under resource‐constrained circumstances. 相似文献
976.
Julio Delgado Filip Josephson Jorge Camarero Blanca Garcia-Ochoa Lucia Lopez-Anglada Carolina Prieto-Fernandez Paula B. van Hennik Irene Papadouli Christian Gisselbrecht Harald Enzmann Francesco Pignatti 《The oncologist》2021,26(3):242-249
On November 5, 2020, a marketing authorization valid through the European Union (EU) was issued for acalabrutinib monotherapy or acalabrutinib in combination with obinutuzumab (AcalaObi) in adult patients with treatment‐naïve (TN) chronic lymphocytic leukemia (CLL) and also for acalabrutinib monotherapy in adult patients with relapsed or refractory (RR) CLL. Acalabrutinib inhibits the Bruton tyrosine kinase, which plays a significant role in the proliferation and survival of the disease. Acalabrutinib was evaluated in two phase III multicenter randomized trials. The first trial (ACE‐CL‐007) randomly allocated acalabrutinib versus AcalaObi versus chlorambucil plus obinutuzumab (ChlObi) to elderly/unfit patients with TN CLL. The progression‐free survival (PFS), as assessed by an independent review committee, was superior for both the AcalaObi (hazard ratio [HR], 0.1; 95% confidence interval [CI], 0.06–0.17) and acalabrutinib (HR, 0.2; 95% CI, 0.13–0.3) arms compared with the ChlObi arm. The second trial (ACE‐CL‐309) randomly allocated acalabrutinib versus rituximab plus idelalisib or bendamustine to adult patients with RR CLL. Also in this trial, the PFS was significantly longer in the acalabrutinib arm (HR, 0.31; 95% CI, 0.20–0.49). Adverse events for patients receiving acalabrutinib varied across trials, but the most frequent were generally headache, diarrhea, neutropenia, nausea, and infections. The scientific review concluded that the benefit‐risk ratio of acalabrutinib was positive for both indications. This article summarizes the scientific review of the application leading to regulatory approval in the EU.Implications for PracticeAcalabrutinib was approved in the European Union for the treatment of adult patients with chronic lymphocytic leukemia who have not received treatment before and for those who have received therapy but whose disease did not respond or relapsed afterward. Acalabrutinib resulted in a clinically meaningful and significant lengthening of the time from treatment initiation to further disease relapse or patient''s death compared with standard therapy. The overall safety profile was considered acceptable, and the benefit‐risk ratio was determined to be positive. 相似文献
977.
Francolini Giulio Trodella Luca Eolo Marvaso Giulia Matrone Fabio Nicosia Luca Timon Giorgia Ognibene Lucia Vinciguerra Annamaria Franzese Ciro Borghetti Paolo Arcangeli Stefano 《International journal of clinical oncology / Japan Society of Clinical Oncology》2021,26(10):1777-1783
International Journal of Clinical Oncology - Historically, non-seminomatous germ cell tumor (NSGCT) has been considered a radio-resistant disease, excluding radiotherapy (RT) from curative... 相似文献
978.
979.
Conti P Caligiuri A Pinto A Roda G Tamborini L Nielsen B Madsen U Frydenvang K Colombo A De Micheli C 《European journal of medicinal chemistry》2007,42(8):1059-1068
Twelve novel conformationally constrained homologues of glutamic acid have been synthesized and pharmacologically characterized at ionotropic glutamate receptors (iGluRs). Synthesis of the target compounds involved 1,3-dipolar cycloaddition of nitrile oxides to suitable dipolarophiles. The structure to the compounds has been assigned by (1)H NMR and, in the case of derivatives (+/-)-4a, (+/-)-4b, (+/-)-5a, and (+/-)-5b, by means of an X-ray crystallographic analysis carried out on intermediate (+/-)-12a. The synthesized amino acids were found to be without affinity (K(i)/IC(50)>100microM) for iGluRs with the exception of compounds (+/-)-4b and (+/-)-5b, which showed a modest affinity for NMDA receptors (K(i)=34 and 13microM, respectively). The results indicate that the increased conformational constraints introduced by the cyclopropane ring and the spiro-attached proline ring are both detrimental to the pharmacological activity. 相似文献